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121.
122.
The influence of estradiol on learning and memory is dependent on a number of factors. The effects of physiological levels of estradiol on the acquisition of a spatial working memory task mediated by the prefrontal cortex (PFC) and the hippocampus were examined in Experiment 1. Ovariectomized Long-Evans rats received daily injections of estradiol or vehicle were tested on the win-shift version of the radial arm maze. A high dose of estradiol benzoate (5 microg) enhanced acquisition of the task, whereas a low dose of estradiol (0.3 microg) increased the number of errors committed over 17 days of testing. Experiment 2 was conducted to examine site-specific influences of estradiol on spatial working memory in well-trained rats. Saline and estradiol cyclodextrin (0.1 and 0.9 microg) were infused into the prelimbic region of the PFC or dorsal hippocampus 40 min prior to testing on the win-shift task. Infusions of estradiol into both brain areas attenuated saline-infusion disruptions in working memory. Specifically, the higher dose of estradiol facilitated working memory when infused into the PFC, whereas the lower dose of estradiol facilitated performance when infused into the dorsal hippocampus. Moreover, working memory was significantly impaired 24 h after infusions of estradiol into the dorsal hippocampus but not the PFC. These data provide further evidence for the notion that estradiol can dose-dependently alter memory processes and suggest that facilitation or disruptions of working memory by estradiol are site- and time-specific. 相似文献
123.
Quas JA Wallin AR Papini S Lench H Scullin MH 《Journal of experimental child psychology》2005,91(4):315-341
This study examined 5- and 6-year-olds' suggestibility and interviewer demeanor as joint predictors of their memory for a novel experience. Session 1 consisted of children taking part in a novel laboratory event. Session 2 took place after approximately a 1-week delay and consisted of children completing both a memory test concerning what happened during the prior event and the Video Suggestibility Scale for Children (VSSC). During the second session, the interviewer behaved either supportively or nonsupportively. Greater acquiescence on the VSSC was associated with fewer correct responses to misleading questions about the laboratory event in the supportive and nonsupportive conditions and with more errors in response to specific questions in the nonsupportive condition. Results indicate that individual differences in children's suggestibility are related to the accuracy of their memory for separate events, although some of these relations may vary depending on the context in which children are interviewed. 相似文献
124.
Miller JR Piper TM Ahern J Tracy M Tardiff KJ Vlahov D Galea S 《Suicide & life-threatening behavior》2005,35(4):448-459
Evidence on the relationship between income inequality and suicide is inconsistent. Data from the New York City Office of the Chief Medical Examiner for all fatal injuries was collected to conduct a multilevel case-control study. In multilevel models, suicide decedents (n=374) were more likely than accident controls (n=453) to reside in neighborhoods with greater income inequality even after controlling for individual characteristics; this relation was modified by age with an effect overall and among decedents aged 15-34 but not among decedents 35-64. These data suggest that income inequality may contribute to the risk of suicide in younger adults. 相似文献
125.
Familiarized names are falsely judgedfamous more often than nonfamiliarized names. Banaji and Greenwald (1995) demonstrated a gender bias in thisfalse fame effect, with the effect being larger for male than for female names. This effect was interpreted as reflecting the operation of
a gender stereotype. However, the famous male names were, in fact, better known than the famous female names. Thus, the presence
of more famous male names during study may have contributed to the observed male-famous association. If so, there should be
no gender bias if the studied famous male and female names are equally famous, and a reversed gender bias should emerge if
the famous female names are more famous than the male names. In two experiments, these predictions were corroborated. A “classical”
gender bias was found only when the famous males were more famous than the famous females. These findings are consistent with
the hypothesis that the gender bias in fame judgments, rather than showing implicit gender stereotyping in the sense of a
transsituational judgment bias, reflects the fact that, in test, participants select a proportion of fame judgments to male
and female names so that it matches the relative degree of fame of male and female names encountered during study. 相似文献
126.
Moor T Mundorff L Bohringer A Philippsen C Langewitz W Reino ST Schachinger H 《Neurobiology of learning and memory》2005,84(3):587-174
Sympathetic nervous system (SNS) activity at the time of acquisition is associated with human memory. However, rather than SNS activity per se, it may be afferent baroreflex feedback that is responsible for this effect. A pharmacological design was employed to unload (SNP, sodium nitro-prusside) and load (norepinephrine) baroreceptors. In addition to two placebo periods, epinephrine and esmolol (a peripherally acting beta1-blocker) served as control conditions for altered cardiac perception. During drug infusion blood pressure, heart rate, and perception of heartbeat were tested. Twenty-four healthy men were participated. The participants viewed emotional slides while their electromyographic eye blink responses to random noise bursts were measured (affective startle modulation paradigm) to determine potential drug impact on emotional processing. Subjects were not informed that memory testing would take place after 4 weeks. Drugs did not impact startle, thus indicating unbiased emotional processing at the time of acquisition. Norepinephrine had no effect on heartbeat perception, but improved (p = .002) recognition memory. SNP (p = .0001) increased heartbeat perception but impaired (p = .038) recognition memory. Epinephrine, on the other hand, increased heartbeat perception (p = .0001) yet did not impair but partially improve memory (effect on high arousing pictures only: p = .05). Heartbeat perception in the placebo condition did not correlate with recognition memory (p's > .5). We suggest that baroreflex unloading, with subsequent feedback activation of the SNS, impairs long-term incidental visual recognition memory in humans while baroreflex loading enhances it. Further, we propose that these memory effects are neither secondary to cardiac sensations that accompany SNS activation nor to altered emotional picture processing at the time of acquisition. 相似文献
127.
The aim of the central nervous system in upright stance is to control an intrinsically unstable plant. Internal disturbances, such as haemodynamics and respiration, constitute an endogenous threat to equilibrium. The way CNS reacts to those perturbations was studied in this work, through the analysis of summary scores taken from posturographic and pneumographic data. Signals were recorded simultaneously during trials administered on a sample population of healthy young adults, while sitting and standing and at paced and spontaneous uncontrolled breathing. The extraction of posturographic and pneumographic parameters was accompanied by the utilization of techniques for the detection of phase synchronization in bivariate data, and the extraction of an interaction index, the mutual information MI. The effects of the biomechanical condition and respiratory amplitude on MI and summary measures were tested with a two-way ANOVA. Summary scores clearly depend on posture condition. Synchronization between breath and postural sway is always present, depends on both biomechanical condition and respiratory threat, and cannot be reduced to a simple linear relation. 相似文献
128.
Preserved fronto-striatal plasticity and enhanced procedural learning in a transgenic mouse model of Alzheimer's disease overexpressing mutant hAPPswe 总被引:3,自引:0,他引:3 下载免费PDF全文
Middei S Geracitano R Caprioli A Mercuri N Ammassari-Teule M 《Learning & memory (Cold Spring Harbor, N.Y.)》2004,11(4):447-452
Mutations in the amyloid precursor protein (APP) gene inducing abnormal processing and deposition of beta-amyloid protein in the brain have been implicated in the pathogenesis of Alzheimer's disease (AD). Although Tg2576 mice with the Swedish mutation (hAPPswe) exhibit age-related Abeta-plaque formation in brain regions like the hippocampus, the amygdala, and the cortex, these mice show a rather specific deficit in hippocampal-dependent learning and memory tasks. In view of recent findings showing that neural systems subserving different forms of learning are not simply independent but that depressing or enhancing one system affects learning in another system, we decided to investigate fronto-striatal synaptic plasticity and related procedural learning in these mutants. Fronto-striatal long-term depression (LTD) induced by tetanic stimulation of the cortico-striatal input was similar in Tg2576 and wild-type control mice. Behavioral data, however, pointed to an enhancement of procedural learning in the mutants that showed robust motor-based learning in the cross maze and higher active avoidance scores. Thus, in this mouse model of AD, an intact striatal function associated with an impaired hippocampal function seems to provide neural conditions favorable to procedural learning. Our results suggest that focusing on preserved or enhanced forms of learning in AD patients might be of interest to describe the functional reorganization of the brain when one memory system is selectively compromised by neurological disease. 相似文献
129.
Bunge SA 《Cognitive, affective & behavioral neuroscience》2004,4(4):564-579
Much of our behavior is guided by rules, or prescribed guides for action. In this review, I consider the current state of
knowledge of how rules are learned, stored in the brain, and retrieved and used as the need arises. The focus is primarily
on studies in humans, but the review is informed by relevant studies in nonhuman primates. Ventrolateral prefrontal cortex
(VLPFC) has been implicated in rule learning, retrieval from long-term memory, and on-line maintenance during task preparation.
Interactions between VLPFC and temporal cortex are required for rule retrieval in nonhuman primates, and brain imaging findings
in humans suggest that rule knowledge is stored in the posterior middle temporal gyrus. Dorsolateral PFC appears to be more
closely related to rule-based response selection than to rule retrieval. An important task for the future is to explain how
PFC, basal ganglia, and temporal, parietal, and motor cortices interact to produce rule-guided behavior. 相似文献
130.
Differences between caregivers and noncaregivers in psychological health and physical health: a meta-analysis 总被引:1,自引:0,他引:1
Providing care for a frail older adult has been described as a stressful experience that may erode psychological well-being and physical health of caregivers. In this meta-analysis, the authors integrated findings from 84 articles on differences between caregivers and noncaregivers in perceived stress, depression, general subjective well-being, physical health, and self-efficacy. The largest differences were found with regard to depression (g = .58), stress (g = .55), self-efficacy (g = .54), and general subjective well-being (g = -.40). Differences in the levels of physical health in favor of noncaregivers were statistically significant, but small (g = .18). However, larger differences were found between dementia caregivers and noncaregivers than between heterogeneous samples of caregivers and noncaregivers. Differences were also influenced by the quality of the study, relationship of caregiver to the care recipient, gender, and mean age of caregivers. 相似文献