Functional decline in the early stages of Alzheimer's disease

At present most reports of functional decline in patients with Alzheimer's Disease (AD) are anecdotal, and few studies have objectively documented the course of the disease. This is a report of a 2-year follow-up of 15 AD patients characterized by mild functional impairment, and 22 age-, sex-, and education-matched control subjects. In a previous cross-sectional study of these 37 subjects and 16 AD patients with moderate functional impairment, we found that measures of memory and attention deficits accounted for much of the impairment observed in functional competence. The current longitudinal study found that these same initial assessments could be used to predict functional decline in the 15 mildly impaired patients. These patients were observed to decline to levels similar to those of the 16 moderate patients. In contrast, the control subjects exhibited little decline during the same period. These results both affirm that it is possible to diagnose AD in its mild form and demonstrate the validity of the initial diagnosis.     

Back to the future: Temporal perspective in the explanation of events

Prospective hindsight involves generating an explanation for a future event as if it had already happened; i.e., one goes forward in time, and then looks back. In order to examine how shifts in perspective might influence people's perceptions of events, we investigated two possible factors: temporal perspective (whether an event is set in the future or past) and uncertainty (whether the event's occurrence is certain or uncertain). In the first experiment, temporal perspective showed little influence while outcome uncertainty strongly affected the nature of explanations for events. Explanations for sure events tended to be longer, to contain a higher proportion of episodic reasons, and to be expressed in past tense. Evidence from the second experiment supports the view that uncertainty mediates not the amount of time spent explaining, but rather subjects' choice of explanation type. The implications of these findings for the use of temporal perspective in decision aiding are discussed.     

Implicit memory for textual materials

As a word moves from isolation in a list to being contextually bound in meaningful discourse, its probability of priming in tests of implicit memory decreases. The present experiments explore whether considerable priming effects can be revealed with conceptual tests of implicit memory as compared to perceptual tests. In the study phase, meaningful actions were described within a coherent text. In Experiment 1 subjects elaborated half of the actions by visual imagery. In Experiment 2, subjects elaborated the actions by enacting them symbolically. In both experiments, subjects in a control condition were simply required to read the same activities. In Experiment 2, a further group of subjects had to detect orthographic errors. The results demonstrated reliable effects of implicit memory in terms of associations with verbs repeated from the studied text. This form of repetition priming for textual materials in a conceptual test of implicit memory was enhanced by both types of elaboration. A word-stem completion task for the same targets revealed a less pronounced and inconsistent priming effect, uninfluenced by both types of elaboration. But the latter form of perceptual priming was found to be more pronounced within the error-detection condition. Measures of explicit memory showed similar effects of elaborative encoding conditions but there were some dissimilarities to measures of implicit memory, too. In general and in accordance with a transfer-appropriate processing view, conceptual tests rather than perceptual tests may be more suitable for detecting effects of implicit memory within the domain of text processing.     

Postfusional latency in stereoscopic slant perception and the primitives of stereopsis

Random dot stereograms of slanted surfaces were constructed, each representing one or two slanted surfaces in different relative arrangements and with different axes. Latency to fusion and from fusion to stereoscopic resolution was measured for each stimulus. It was found that latency to fusion was always very brief but that latency to stereoscopic resolution varied markedly, depending upon the orientation and arrangement of the stereoscopic surfaces. A gradient of discontinuities at a surface boundary produced an instant slant response for that surface, whereas a gradient of absolute disparities across the surface did not, except under conditions where vertical declination (a form of orientation disparity) was present. We conclude that stereopsis is not based on the primitives used in matching the images for fusion and that it is, at least initially, a response to disparity discontinuities which play no role in the fusion process. We also conclude that vertical declination is responded to globally as a slant around a horizontal axis but that other forms of orientation disparity are ineffective. The evidence from our experiments does not support the existence of a stereoscopic ability to respond globally to differences in magnification (or spatial frequency). It is suggested that stereoscopic perception of slant around a vertical axis is slow because it results from the integration of local processes.     

FAMILY AND WORK PREDICTORS OF PSYCHOLOGICAL WELL-BEING AMONG HISPANIC WOMEN PROFESSIONALS

This study examines the relative contributions of job- and gender-related variables to the mental health of Hispanic women professionals. Hispanic women professionals, managers and business owners ( n = 303) were surveyed using the mailing list of a Hispanic professional women's organization. Results of multiple regression analyses indicate that income and Hispanic group were consistently related to mental health measures. Spouse support and ethnicity of spouse were associated with measures of stress in balancing roles and psychological distress symptoms. Marital status was related to personal life satisfaction (married women reported more satisfaction), and having young children was negatively associated with personal and professional satisfaction. Experience of discrimination, job stress and peer support were also significantly related to mental health measures. Although preliminary, this study underscores the importance of both job- and gender-related factors in research on the effects of employment on Hispanic women's mental health.     

Anatomoclinical correlations of the aphasias as defined through computerized tomography: Exceptions

We have studied the frequency of exceptions to classical aphasia localizations in right-handed, literate, adult, native speakers of Italian with focal vascular left-hemisphere lesions, correlating clinical and computerized tomography data. Two hundred sixty-seven subjects were given computerized tomography (CT) examinations; lesions were mapped onto lateral diagrams and the sites of the lesions were defined. Patients were then classified as nonfluent aphasics, fluent aphasics, and nonaphasics. Patients with negative CT scans (n = 10) or only "deep" lesions (n = 50) were not studied for anatomoclinical correlations. Of the remaining 207 patients, 36 presented unexpected findings. There were seven cases of fluent aphasia and "anterior" CT lesions and six cases with nonfluent aphasia and "posterior" CT lesions among them. The significance of these findings is discussed.     

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The American Journal of Psychoanalysis -