Histamine enhances inhibitory avoidance memory consolidation through a H2 receptor-dependent mechanism

Several evidences suggest that brain histamine is involved in memory consolidation but the actual contribution of the hippocampal histaminergic system to this process remains controversial. Here, we show that when infused into the CA1 region of the dorsal hippocampus immediately after training in an inhibitory avoidance task, but not later, histamine induced a dose-dependent promnesic effect without altering locomotor activity, exploratory behavior, anxiety state or retrieval of the avoidance response. The facilitatory effect of intra-CA1 histamine was mimicked by the histamine N-methyltransferase inhibitor SKF-91844 as well as by the H2 receptor agonist dimaprit and it was blocked completely by the H2 receptor antagonist ranitidine. Conversely, the promnesic action of histamine was unaffected by the H1 receptor antagonist pyrilamine, the H3 receptor antagonist, thioperamide, and the NMDAr polyamine-binding site antagonist ifenprodil. By themselves, ranitidine, pyrilamine, thioperamide, and ifenprodil did not affect IA memory consolidation. Our data indicate that, when given into CA1, histamine enhances memory consolidation through a mechanism that involves activation of H2 receptors; however, endogenous CA1 histamine does not seem to participate in the consolidation of IA memory at least at the post-training times analyzed.     

Cognitive and Psychosocial Consequences of Hurricanes Katrina and Rita Among Middle-Aged, Older, and Oldest-Old Adults in the Louisiana Healthy Aging Study (LHAS)

This study examined the impact of Hurricanes Katrina and Rita on cognitive and psychosocial functioning among middle-aged (45-64 years), older (65-89 years) and oldest-old adults (90 years and over) in the Louisiana Healthy Aging Study (LHAS). Analyses of pre- and post-disaster cognitive data showed storm-related decrements in working memory for the middle-aged and older adults, but not for the oldest-old adults. Regression analyses confirmed that measures of social engagement and storm-related disruption significantly predicted pre- to post-disaster differences in short-term and working memory performance for the middle-aged and older adults only. These results are consistent with a burden perspective on post-disaster psychological reactions. Implications for current views of disaster reactions are discussed.     

Why pigeons say what they do: reinforcer magnitude and response requirement effects on say responding in say-do correspondence

The effects of reinforcer magnitude and response requirement on pigeons' say choices in an experimental homologue of human say-do correspondence were assessed in two experiments. The procedure was similar to a conditional discrimination procedure except the pigeons chose both a sample stimulus (the say component) and a comparison stimulus that corresponded to it (the do component). Correspondence was trained on red, green, and white key colors before the duration of food presentations following correspondence on each key color (Experiment 1) and the number of key pecks required as the say response on each key color (Experiment 2) were manipulated in an attempt to influence the initial say response. The frequency of say responses on each key color coincided with programmed changes in the duration of food presentations and the key-peck requirements assigned to each key color. Correspondence accuracy remained stable in all conditions, even those in which the say responding occurred primarily on two of the three key colors. Implications for human behavior are discussed.     

The uninheritable state and the post-public sphere

In The Politics of Postsecular Religion (2008), Ananda Abeysekara contends that justice has to be predicated on the forgetting of systems of commensuration and calculation for an im-possibility – i.e., an ethical excess – that cannot be circumscribed by repeatable and calculable law. This ethical excess defines a space of politics that would similarly abandon the legacies of codified public memory. However, many of the elements that he identifies with uninheriting and active forgetting coincide with the ‘post-public’ sphere of Sri Lankan political culture, which undermines Habermasian assumptions of a rational and transparent public sphere. The structural forgetfulness that Abeysekara identifies with justice can be discerned in the artifacts and artifices of the Sri Lankan securitized state that is an unjust apparatus of extra-legal violence, moral indifference and orchestrated deniability.     

Little Jeremy's Struggle with Autism,Schizophrenia and Parano a

Since its formulation by Bleuler in 1911, the generalisation of the term ''autism'', mainly due to its use by Kanner in 1943 and its remake by authors of Kleinian inspiration, implies problems which mislead us, blurring our perception and understanding of clinical realities. Our psychoanalytical possibilities can be enlarged by a clear knowledge of the history of psychoanalysis, a dynamic approach to psychiatric classification and to problems related to our conception of the setting. On the basis of a case history the author shows how a child and its family worked through major autistic symptoms and proposes new approaches to some psychoanalytical concepts.     

The Relationship Between Sexual Orientation and Gender Identification Among Males in a Cross-Cultural Analysis in Brazil, Turkey and Thailand

This study measures and compares the level of congruency between male sexual orientation and gender identification using the Kinsey Scale in three cultures: Brazil (Florianópolis), Turkey (Istanbul) and Thailand (Bangkok) with social class as the control mechanism. Quantitative techniques are utilized in comparing the self-evaluation of sexual orientation and gender identification among young men with same-sex, opposite-sex and both-sex orientations or behaviors. Results: In all three cultures, homosexuals were much more likely than bisexuals or heterosexuals to enjoy receiving anal sex and performing fellatio. Bisexual and heterosexual men, as expected, reported enjoying vaginal penetration and cunnilingus more than homosexual men. Same-sex oriented male self-evaluations of homosexual orientation and feminine gender identification scored similarly on the Kinsey Scale (0–6) in all three countries. These data support the traditional identity trichotomy used in the field: homosexuality, bisexuality and heterosexuality. When controlling for nationality only small differences were found amongst the participants; however, social class or level of education did have a significant effect on the relationship between self-evaluation of sexual orientation and gender identification.     

Beyond the Grand Illusion: What Change Blindness Really Teaches Us About Vision

Experiments on scene perception and change blindness suggest that the visual system does not construct detailed internal models of a scene. These experiments therefore call into doubt the traditional view that vision is a process in which detailed representations of the environment must be constructed. The non-existence of such detailed representations, however, does not entail that we do not perceive the detailed environment. The “grand illusion hypothesis” that our visual world is an illusion rests on (1) a problematic “reconstructionist” conception of vision, and (2) a misconception about the character of perceptual experience.     

Organizational social context and psychopathology of youth in residential care: The intervening role of youth–caregiver relationship quality

Drawing on an ecological approach with multiple informants, this study investigated the mediating role of youth–caregiver relationship quality in associations between different features of residential care settings' organizational social context and youth's psychopathology. Participants were 378 youth aged between 12 and 25 years old, and 54 caregivers aged between 24 and 57 years old, from 29 generalist residential youth care settings in Portugal. Given the hierarchical structure of data, analyses were performed using multilevel modeling. Results revealed that organizational social contexts characterized by higher levels of engagement, stress, and centralization, as perceived by the caregivers, were associated with lower levels of youth's externalizing problems (e.g., aggressive behavior and delinquency), reported by the caregivers, via better youth–caregiver relationship quality, perceived by the youth in care. These findings highlight the relevance of creating an organizational social context in residential care settings that supports caregivers in establishing high-quality relationships with the youth in care, thereby promoting their mental health. This study contributes to the clarification of conflicting findings in previous studies of this field, by offering further empirical investigation of these issues.