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761.
Da Cunha C Wietzikoski S Wietzikoski EC Silva MH Chandler J Ferro MM Andreatini R Canteras NS 《Neurobiology of learning and memory》2007,87(4):451-463
The bilateral intranigral infusion of 1 micromol 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in adult male Wistar rats caused a specific and partial loss of substantia nigra pars compacta (SNc) dopamine neurons, a partial depletion of striatal dopamine, and a deficit to learn the intra-maze cued version of the Morris water maze. Pre-training the SNc rats in the spatial version of the water maze or simply maintaining the animals on the water maze platform reversed this deficit. This improvement was even observed when the order of the extra-maze cues presented to the rats during pre-training of the spatial version was changed during training of the intra-maze cued version. However, this deficit was not reversed either by maintaining the animals on the platform if the spatial cues were surrounded and covered with a curtain or by swimming sessions in the maze without the escape platform and the curtain. These findings suggest that none of the following elements alone, learned during the spatial task pre-training, could help SNc rats learn the intra-maze cued task: improvement of swimming skills or knowledge of the existence of the escape platform; distance between the platform and the border of the pool; location of a particular extra-maze cue; relations among extra-maze cues. However, the simultaneous presence of the escape platform and extra-maze cues (irrespective of their relational configuration) during the pre-training sessions proved to be necessary for this improving effect to occur. 相似文献
762.
Quiroz-Padilla MF Guillazo-Blanch G Vale-Martínez A Torras-García M Martí-Nicolovius M 《Neurobiology of learning and memory》2007,88(2):198-207
To investigate whether the parafascicular (PF) nucleus of the thalamus is involved in different learning and memory tasks, two experiments were carried out in adult male Wistar rats that were submitted to pre-training bilateral N-methyl-d-aspartate PF infusions (0.15M, pH 7.4; 1.2 microl/side, 0.2 microl/min). In Experiment 1, we evaluated the effects of PF lesions in two identical 30-trial training sessions, separated by a 24-h interval, of a two-way active avoidance conditioning. PF-lesioned rats exhibited impaired performance in both sessions, measured by number of avoidance responses. In Experiment 2, the effects of PF lesions were assessed in a training session (5 trials) and a 24-h retention test (2 retention trials and 2 relearning trials) of an odor-discrimination task. PF lesions did not significantly disrupt the acquisition or the first retention trial, which was not rewarded. However, lesioned animals' performance was clearly affected in subsequent trials, following the introduction of the single non-rewarded trial. Current data are discussed considering evidence that lesions of the PF nucleus affect learning and memory functions mediated by anatomically related areas of the frontal cortex and striatum. 相似文献
763.
Pereira LO Arteni NS Petersen RC da Rocha AP Achaval M Netto CA 《Neurobiology of learning and memory》2007,87(1):101-108
Environmental enrichment (EE) results in improved learning and spatial memory, as well as attenuates morphological changes resulting from cerebral ischemia in adult animals. This study examined the effects of daily EE on memory deficits in the water maze and cerebral damage, assessed in the hippocampus and cerebral cortex, caused by neonatal hypoxia-ischemia. Male Wistar rats in the 7th postnatal day were submitted to the Levine-Rice model of neonatal hypoxia-ischemia (HI), comprising permanent occlusion of the right common carotid artery and a period of hypoxia (90 min, 8%O(2)-92%N(2)). Starting two weeks after the HI event, animals were stimulated by the enriched environment (1h/day for 9 weeks); subsequent to the stimulation, performance of animals in the water maze was assessed. HI resulted in spatial reference and working memory impairments that were completely reversed by EE. Following the behavioral study, animals were killed and the hippocampal volume and cortical area were estimated. There was a significant reduction of both hippocampal volume and cortical area, ipsilateral to arterial occlusion, in HI animals; environmental stimulation had no effect on these morphological measurements. Presented data indicate that stimulation by the daily environmental enrichment recovers spatial memory deficits caused by neonatal hypoxia-ischemia without affecting tissue atrophy in either hippocampus or cortex. 相似文献
764.
Dr Michael J. Boulton Mark Trueman Samantha Bishop Emma Baxandall Abigail Holme Sarah-Louise Smith Fernanda Vohringer Louise Boulton 《Counselling and Psychotherapy Research》2007,7(3):188-195
Pupils (n=99) from two secondary schools in the UK were interviewed to investigate their views and experiences of the peer counselling for bullying service set up in their school. They were asked about various things concerning (1) the characteristics of the service and service providers that they valued and (2) their reasons for not using the service. Overall, a majority of participants reported a willingness to use this type of service and they identified numerous characteristics that they valued, including peer counsellors with good listening skills who were trustworthy and maintained confidentiality. A noteworthy proportion of participants also wanted the service to provide advice on solving bullying‐related problems. Some barriers to using the service were also identified, including fear of being stigmatised. Responses offered by girls and boys, and by users and non‐users of the service, were compared and several significant differences emerged. The results are discussed in terms of the implications for adults who run this type of service and the peer counsellors who deliver it. 相似文献
765.
Different time course for the memory facilitating effect of bicuculline in hippocampus, entorhinal cortex, and posterior parietal cortex of rats 总被引:2,自引:0,他引:2
Several lines of evidence indicate that gamma-aminobutyric acid (GABA) type A (GABA(A)) receptors regulate memory consolidation. Here we studied the effect on consolidation of the selective antagonist of GABA(A) receptors, bicuculline, given into several regions of the cortex at different times after one-trial step-down inhibitory avoidance (0.5 mA, 2-s footshock). Rats were bilaterally implanted with cannulae aimed at the CA1 region of the dorsal hippocampus, entorhinal cortex or posterior parietal cortex, three areas known to be involved in the memory consolidation of this task. At different times after training, bicuculline (0.5 microg/side) was infused into the above mentioned structures. Bicuculline increased memory retention when administered either immediately or 1.5h after training into CA1, and both immediately and 3h after training in the entorhinal or parietal cortex. Thus, in agreement with previous findings using other drugs, the response was biphasic in these latter structures. This suggests that GABAergic mechanisms normally downregulate, memory processing by inhibiting on-going activities necessary for consolidation at the times in which bicuculline was effective in each structure. Based on previous findings, in the hippocampus, such activity involves a number of receptors and signaling pathways in the first 1.5h after training. In the entorhinal and parietal cortex memory-related activities include the participation of protein kinase A and extracellularly regulated kinase (ERK) twice, right after training and then again 3h later. 相似文献
766.
The goal of the present study was to compare the relative distress of homosexual and heterosexual Brazilian men and women on scenarios in which they imagined their partners sexually or emotionally involved with another person, using a forced-choice paradigm and continuous measures. Participants were 68 heterosexual men, 72 heterosexual women, 42 homosexual men, and 35 homosexual women. On the forced-choice questions heterosexual men (39 on one question and 37 on the other) were more upset than their female counterparts (21 on one question and 15 on the other) by scenarios of sexual infidelity than those of emotional infidelity. On questions using continuous measures no significant difference was found between pleasurable sex and attachment scenarios for heterosexual women or heterosexual men. On the highly upsetting scenarios heterosexual men discriminated between flirting and both pleasurable sex and attachment scenarios, being less disturbed by the former. In contrast, heterosexual women were equally distressed by the three scenarios. Scores for the homosexual men and homosexual women fell in between those of the heterosexual men and heterosexual women and did not show a clear cut preference for the sexual infidelity or the emotional alternative on the forced-choice paradigm. However, on the continuous measures of jealousy homosexuals resembled heterosexuals of the opposite sex. There was no evidence that jealousy would be less intense among homosexuals although reproductive outcomes were not at risk. 相似文献
767.
Ferreira F 《Cognitive psychology》2003,47(2):164-203
Research on language comprehension has focused on the resolution of syntactic ambiguities, and most studies have employed garden-path sentences to determine the system's preferences and to assess its use of nonsyntactic sources information. A topic that has been neglected is how syntactically challenging but essentially unambiguous sentences are processed, including passives and object-clefts--sentences that require thematic roles to be assigned in an atypical order. The three experiments described here tested the idea that sentences are processed both algorithmically and heuristically. Sentences were presented aurally and the participants' task was to identify the thematic roles in the sentence (e.g., Who was the do-er?). The first experiment demonstrates that passives are frequently and systematically misinterpreted, especially when they express implausible ideas. The second shows that the surface frequency of a syntactic form does not determine ease of processing, as active sentences and subject-clefts were comprehended equally easily despite the rareness of the latter type. The third experiment compares the processing of subject- and object-clefts, and the results show that they are similar to actives and passives, respectively, again despite the infrequent occurrence in English of any type of cleft. The results of the three experiments suggest that a comprehensive theory of language comprehension must assume that simple processing heuristics are used during processing in addition to (and perhaps sometimes instead of) syntactic algorithms. Moreover, the experiments support the idea that language processing is often based on shallow processing, yielding a merely "good enough" rather than a detailed linguistic representation of an utterance's meaning. 相似文献
768.
Although the changes in kinematics of infant reaching have been studied, few researchers have investigated the improvement of reaching regarding objects of distinct physical properties. The aim of this longitudinal study was to verify the impact of object size and rigidity on the development of reaching in 4-6-month-old infants. Four infants were observed with a motion capture system during trials with four objects of distinct sizes and rigidity. A total of 188 reaches were analyzed by using the 3D movement reconstruction. Our results showed that reaching frequency, mean velocity, and straightness index increased with age. The number of movement units decreased with age and increased for small objects. Rigidity was not shown to affect reaching trajectories. These findings suggest that infants are capable of perceiving the more relevant object properties, thus using their available motor capabilities to modify the essential variables so that they can reach the target more accurately. 相似文献
769.
Pereira M 《Journal of comparative psychology (Washington, D.C. : 1983)》2006,120(4):411-415
This study characterizes the maternal behavior in the subterranean rodent Ctenomys pearsoni and determines whether lactating females develop a selective bonding to their own pups in addition to maternal responsiveness. Mother-litter interactions were observed daily for 2 months; during the 1st postpartum week, selectivity and preference tests for own or alien pups were performed. Lactating females exhibited all patterns of maternal behavior observed in other rodent species and equally responded with care-taking behaviors to their own and alien pups, although they were able to discriminate between them, showing preference for their own pups. Results are discussed, taking into account the possible role of this behavior in shaping different aspects of life underground in ctenomyid species. 相似文献
770.
VanMarle K Aw J McCrink K Santos LR 《Journal of comparative psychology (Washington, D.C. : 1983)》2006,120(4):416-426
Humans and nonhuman animals appear to share a capacity for nonverbal quantity representations. But what are the limits of these abilities? Results of previous research with human infants suggest that the ontological status of an entity as an object or a substance affects infants' ability to quantify it. We ask whether the same is true for another primate species-the New World monkey Cebus apella. We tested capuchin monkeys' ability to select the greater of two quantities of either discrete objects or a nonsolid substance. Participants performed above chance with both objects (Experiment 1) and substances (Experiment 2); in both cases, the observed performance was ratio dependent. This finding suggests that capuchins quantify objects and substances similarly and do so via analog magnitude representations. 相似文献