Histamine reverses a memory deficit induced in rats by early postnatal maternal deprivation

Early partial maternal deprivation causes long-lasting neurochemical, behavioral and brain structural effects. In rats, it causes a deficit in memory consolidation visible in adult life. Some of these deficits can be reversed by donepezil and galantamine, which suggests that they may result from an impairment of brain cholinergic transmission. One such deficit, representative of all others, is an impairment of memory consolidation, clearly observable in a one-trial inhibitory avoidance task. Recent data suggest a role of brain histaminergic systems in the regulation of behavior, particularly inhibitory avoidance learning. Here we investigate whether histamine itself, its analog SKF-91844, or various receptor-selective histamine agonists and antagonists given into the CA1 region of the hippocampus immediately post-training can affect retention of one-trial inhibitory avoidance in rats submitted to early postnatal maternal deprivation. We found that histamine, SKF-91844 and the H2 receptor agonist, dimaprit enhance consolidation on their own and reverse the consolidation deficit induced by maternal deprivation. The enhancing effect of histamine was blocked by the H2 receptor antagonist, ranitidine, but not by the H1 receptor antagonist pyrilamine or by the H3 antagonist thioperamide given into CA1 at doses known to have other behavioral actions, without altering locomotor and exploratory activity or the anxiety state of the animals. The present results suggest that the memory deficit induced by early postnatal maternal deprivation in rats may in part be due to an impairment of histamine mediated mechanisms in the CA1 region of the rat hippocampus.     

For your Eyes Only: A Q-Methodology on the Ontology of Happiness Among Chronically Ill Filipino Elderly in a Penal Institution

Happiness is a positive phenomenon that is universal in nature and is therefore, pertinent to all human beings. However, the definition of happiness differs from person to person, and varies among cultures, economic status, social connectedness, spiritual upbringing and daily situations. An individual’s contextual perception of happiness can change when subjected to bleak conditions such as incarceration wherein inmates, especially those who are old and are experiencing health impairments are stripped off with their customary source of happiness. Since Filipinos are known to be as “happy people,” this study purports to surface the different facets of what constitute happiness in the context of a penal institution in the Philippine setting. The Q-methodology is the primary design used in the study. It combines the objectivity of quantitative approach with the essence of human experiences as explored in qualitative studies. The participants (P-sample) were twenty elderly inmates suffering from chronic ailments. They were asked to arrange 32 statements (Q-sample), derived from the initial interview, in the Q-sort table based on their degree of agreement, which were then further explicated in the post-sort interviews. The results were then subjected to by-person factor analysis with varimax rotation using the PQ Method version 2.11. Five profiles emerged from the by-person factor analysis, namely: (1) ‘Sense of Affinity’, (2) ‘Sense of Opportunity’, (3) ‘Sense of Indemnity’, (4) ‘Sense of Positivity’ and (5) ‘Sense of Resiliency’. The discussion focused on similarities and differences among profiles regarding the four principal themes (familial, social, internal and spiritual components of happiness) derived from the statements used as the Q-sample. The perception of happiness varies from profile to profile. The differences in views on what constitutes happiness among profiles are more prominent than their said similarities. Most leanings are directed toward the familial and spiritual aspects of happiness however, happiness can also be internally motivated and cognitively construed. While happiness has a direct relationship to an individual’s overall perception of well-being, the nurse, being the primary provider of holistic care, plays a pivotal role in promoting optimum health through awareness, knowledge, and appreciation of vis-a vis an unwavering involvement with the unique and distinct psychological and emotional needs of the elderly inmates characterized by respect, openness, authenticity and inter-subjectivity.     

Emotional appraisal is influenced by cardiac afferent information

Influential models highlight the central integration of bodily arousal with emotion. Some emotions, notably disgust, are more closely coupled to visceral state than others. Cardiac baroreceptors, activated at systole within each cardiac cycle, provide short-term visceral feedback. Here we explored how phasic baroreceptor activation may alter the appraisal of brief emotional stimuli and consequent cardiovascular reactions. We used functional MRI (fMRI) to measure brain responses to emotional face stimuli presented before and during cardiac systole. We observed that the processing of emotional stimuli was altered by concurrent natural baroreceptor activation. Specifically, facial expressions of disgust were judged as more intense when presented at systole, and rebound heart rate increases were attenuated after expressions of disgust and happiness. Neural activity within prefrontal cortex correlated with emotionality ratings. Activity within periaqueductal gray matter reflected both emotional ratings and their interaction with cardiac timing. Activity within regions including prefrontal and visual cortices correlated with increases in heart rate evoked by the face stimuli, while orbitofrontal activity reflected both evoked heart rate change and its interaction with cardiac timing. Our findings demonstrate that momentary physiological fluctuations in cardiovascular afferent information (1) influence specific emotional judgments, mediated through regions including the periaqueductal gray matter, and (2) shape evoked autonomic responses through engagement of orbitofrontal cortex. Together these findings highlight the close coupling of visceral and emotional processes and identify neural regions mediating bodily state influences on affective judgment.     

Processing of representations in declarative and procedural working memory

The article investigates the relation between declarative and procedural working memory (WM; Oberauer, 2009). Two experiments test the assumption that representations in the two subsystems are selected for processing in analogous ways. Participants carried out a series of decisions on memorized lists of digits. For each decision, they had to select declarative and procedural representations. Regarding declarative representations, participants selected a memory set and a digit within this set as the input to each decision. With respect to the procedural representations, they selected a task set to be applied to the selected digit and a response within that task set. We independently manipulated the number of lists and the number of tasks to be switched among (one, two, or three; Experiment 1) and preparation time for a list switch (Experiment 2). For three effects commonly observed in task-switch studies, analogues in declarative WM were found: list-switch costs, mixing costs, and residual switch costs. List- and task-switch costs were underadditive, suggesting that declarative and procedural representations are selected separately and in parallel. The findings support the hypothesis of two analogous WM subsystems.     

Ion-beam synthesis of amorphous gallium nitride

Amorphous gallium nitride (a-GaN) has been synthesized for the first time by implanting gallium into amorphous silicon nitride (a-SiNx) films. The a-GaN is only formed when gallium is implanted into hydrogenated amorphous silicon nitride (a-SiNx:Hy) films with x > 1.5. The nitrogen concentration x of the substrate is varied by changing the feed-gas ratio during plasma-enhanced chemical vapour deposition of the nitride film. Using a pre-determined composition and implant condition, the implanted gallium is made to bond with the nitrogen to form a surface layer of a-GaN. Low-temperature annealing, compatible with large-area glass substrates, is then used to increase the thickness of the a-GaN and to transform more of the a-SiNx. X-ray photoelectron spectroscopy and Rutherford back-scattering spectroscopy have been used to examine the bond structure, composition and the depth profile of the synthesized material.     

Personality styles and suggestibility: A differential approach

This study addresses the relationship between personality styles measured with the Portuguese adaptation of the Millon Index of Personality Styles Revised – MIPS-R and interrogative suggestibility assessed by the Portuguese adaptation of the Gudjonsson Suggestibility Scale – GSS1. Hypotheses predicted individual differences in suggestibility and that these differences correspond to differences in individuals’ personality styles. The study was conducted with a sample of 258 individuals (M_age = 31.8 years, SD = 12.0). Results showed that there were individual differences in suggestibility and that these differences corresponded to certain personality characteristics, mainly related to the Thinking Styles and some Behaving Styles.     

Implicit Attitudes Toward Arab-Muslims and the Moderating Effects of Social Information

Three studies examined the relative valence and strength of implicit attitudes toward Arab-Muslims using the Implicit Association Test (IAT) while exploring the moderation of such implicit effects. Studies have suggested that repeated exposure to information associating members of a social group (e.g., Arab-Muslims) with evaluative attributes (e.g., terrorism) might create automatic attitudes toward them. Consistent with this notion, the IAT results indicated strong implicit preference for White over Arab-Muslim, whereas the magnitude of such a bias was substantially diminished when assessed by explicit measures (Study 1). It is also interesting to note that participants exhibited implicit preference for Black over Arab-Muslim when measured by the IAT, whereas no difference was found between the 2 groups in stimulus familiarity and in explicit attitudes (Studies 2 and 3). However, such implicit effects were moderated when participants were exposed to positive information about Arab-Muslims (Study 3). Theoretical and practical implications of these findings are further discussed.     

Book Reviews

Abstract

The aim of this paper is to identify what I take to be the main conceptual problem in Lewis’ semantics for counterfactuals when the Limit Assumption (LA) is not satisfied, what I call the Discrimination Problem (DP), and to present and discuss a modification of Lewis’ semantics that aims at solving DP. First, I outline Lewis’ semantics, highlighting the aspects that will be relevant for our discussion. Second, I present DP and discuss it with a heuristic example. Third, I present the new proposal and comment some formal consequences and the objections they give rise to. Fourth, I present an allegedly equivalent version of the proposal and discuss the difference between counterfactuals and strict conditionals. Finally, I defend that the two proposals are different and argue for the first one as the best way of capturing two intuitions that seem in conflict when the LA is not satisfied. I conclude with a dilemma: either the proposal here defended works or LA is inescapable. Thus, if the proposal doesn’t work, the paper must then be considered as an indirect defense of the Limit Assumption.     

Establishing a relational field that fosters learning processes: Some tentative propositions derived from trainee experiences

In this article, we look at the recent introduction of more relational-oriented learning principles and how they translate into practice by documenting the experiences of both trainees and instructors. It became clear that actors held different opinions and viewpoints on learning objectives and process ingredients for achieving these objectives. This divergence in opinions resulted in an “impoverished” learning trajectory. We suggest that remedying this situation implies introducing reflexivity regarding learning processes or, stated otherwise, addressing “meta-cognitions” that participants inevitably bring to the process as they affect the way in which people engage in the relational field that encompasses the learning trajectory. Despite some recent arguments in favour of a distinction between cognitive and meta-cognitive mediation, we argue for a similar approach with respect to both types of mediation. We end this article by suggesting that designing learning trajectories with this dual concern in mind might open the road to “learning to learn”.