Stiff man syndrome

Our 51-year old patient developed low back pain and an increase of tonus mainly in the left limb and trunk muscles. Microscopic examination of the muscles and electronmicroscopic examination of the sural nerve and that of the gastronemic muscle did not show any specific deviation. On the basis of spontaneous activity observed during EMG examination, protracted motor activity of great amplitude when moved passively, as well as characteristic clinical symptoms and the disease process Stiff-man syndrome was diagnosed. Considering literature data, we tried applying diazepam (Seduxen and Rivotril)-presumably increasing the praesynaptic inhibition and affecting the reticular system of the brain stem-, as well as GABA medicaments (Lioresal and Depakine) increasing synaptic transport. By giving Seduxen, Rivotril and Baclofen simultaneously a lasting remission of symptoms could be reached. Applying Depakine in combination with the above medicines proved ineffective, presumably because of synergetic side effects.     

Hemispheric dominance in schizophrenics as determined on extrapyramidal side effects of neuroleptics

Phenomena observed during treatment with neuroleptics were clinically measured in an attempt to determine the difference in vulnerability of the two hemispheres and the relation between this difference and schizophrenic diseases. In the group of systematic schizophrenias the increase in tonus was significantly higher in the dominant hemisphere. This finding is considered a verification of the nosological hypothesis of schizophrenias.     

Classical and connectionist models: Levels of description

To begin, I introduce an analysis of interlevel relations that allows us to offer an initial characterization of the debate about the way classical and connectionist models relate. Subsequently, I examine a compatibility thesis and a conditional claim on this issue. With respect to the compatibility thesis, I argue that, even if classical and connectionist models are not necessarily incompatible, the emergence of the latter seems to undermine the best arguments for the Language of Thought Hypothesis, which is essential to the former. I attack the conditional claim of connectionism to eliminativism, presented by Ramsey et al. (1990), by discrediting their discrete characterization of common-sense psychological explanations and pointing to the presence of a moderate holistic constraint. Finally, I conclude that neither of the arguments considered excludes the possibility of viewing connectionist models as forming a part of a representational theory of cognition that dispenses with the Language of Thought Hypothesis.     

A note on the Chinese Room

Searle's Chinese Room was supposed to prove that computers can't understand: the man in the room, following, like a computer, syntactical rules alone, though indistinguishable from a genuine Chinese speaker, doesn't understand a word. But such a room is impossible: the man won't be able to respond correctly to questions like ‘What is the time?’, even though such an ability is indispensable for a genuine Chinese speaker. Several ways to provide the room with the required ability are considered, and it is concluded that for each of these the room will have understanding. Hence, Searle's argument is invalid.     

Loss context enhances preferences for generosity but reduces preferences for honesty: Evidence from a combined behavioural-computational approach

The current literature has revealed mixed evidence on whether loss (vs. gain) context promotes or curtails human prosociality. The current study (N=96) aimed to address this issue by examining whether gain/loss context has distinct effects on different prosocial preferences combining computational modelling with Dictator Game and Message Game. These interactive games allow for dissociating preferences for generosity and honesty, which have been respectively associated with intuitive and deliberative systems. Our behavioural and computational modelling results indicate that loss context enhances concerns for generosity but reduces concerns for honesty. These findings support an account under the framework of dual process model asserting that loss facilitates intuitive responses during social decision-making, regardless of whether they are prosocial or proself. The current findings reconcile previous debates on the relationship between loss-gain context and human prosociality and shed light on the design of institutions to promote human prosocial behaviours.     

Towards a topological philosophy

This article examines the use of mathematical concepts in philosophy, focusing on topology, which may be viewed as a modern supplement to geometry. We show that Plato and Parmenides were already employing geometric ideas in their research, and discuss three examples of the application of topology to philosophical problems: the first concerns the analysis of the Cartesian distinction between res extensa and res cogitans, the second the ontology of possible worlds of Wittgenstein's Tractatus, and the third Leibniz's monadology. We also consider the role of topology in mathematical explanations of the sort found in science, arguing that it can perform a role in philosophy that is of comparable importance.     

Relation between resilience and personality traits: The role of hopelessness and age

Resilience refers to the process by which individuals use the ability to cope with challenges to successfully adapt to adverse situations, inclining towards the future and hope. The main aim of this study was to analyze the relation between resilience, personality traits, and hopelessness. Furthermore, we conducted comparisons between two age groups: young and older adults. The sample comprised 439 Spanish participants (66.7% women; M = 43.73, SD = 26.41; age range = 18–98 years). The Connor–Davidson Resilience Scale, NEO-Five Factor Inventory, and Beck Hopelessness Scale were used to measure the main study variables. The results revealed a negative relation between resilience and neuroticism, and a positive association with the other personality traits. Additionally, levels of resilience were found to be negatively related to hopelessness. The group of older adults showed significantly lower resilience levels than the young adults, although age was not a significant predictor of resilience. Neuroticism, extraversion, openness, and hopelessness were the only predictors of resilience for the current study. This work contributes to the study of resilience and related factors, by attempting to understand the role of resilience and resistance to risk and how individuals tackle challenges over time, with important implications for mental health.