祛弱权:生命伦理学的人权基础

没有任何一个人始终处在坚韧性状态,每一个人都不可避免地时刻处在脆弱性状态.因此,祛除普遍的脆弱性的价值诉求在道德实践中就转化为作为人权的祛弱权.生命伦理学以祛弱权为其人权基础,也就成了有根的伦理学.     

Gender Differences in Stress and Coping among Elderly Patients on Hemodialysis

The study investigated whether gender differences in the stressor, coping strategies, and how they associate stress and copings among 875 elderly patients undergoing hemodialysis in Taiwan. Chi-square tests, MANOVA and Structural Equation Modeling were used to attain the research purposes. The results found that the women had reported higher stress in response to physical and vessel problems and higher scores in using emotion-oriented and support-seeking coping strategies, while the men reported higher stress in reproductive system functioning and higher score in using avoidance as a coping strategy. Furthermore, the results from SEM demonstrated that after controlling for patient characteristics, no statistical difference was found between the two groups with regard to their linking of stress and coping strategies.     

集权的道德哲学反思

集权是以功利目的论为理论根基,以"例外特质"为道德心理基础,以独断的道德相对论和独断的道德一元论的不良混合为道德特征,以暴力和强制为后盾的不道德的特殊权利.集权践踏人权、违背人性,不配享有权利之名,因而是必须祛除的对象.     

Two-dimensional symmetric form discrimination: Fast learning,but notthat fast

Several authors have characterized a striking phenomenon of perceptual learning in visual discrimination tasks. This learning process is selective for the stimulus characteristics and location in the visual field. Since the human visual system exploits symmetry for object recognition we were interested in exploring how it learns to use preattentive symmetry cues for discriminating simple, meaningless, forms. In this study, similar to previous studies of perceptual learning, we asked whether the effects of practice acquired in the discrimination of pairs of shape with a specific orientation of the symmetry axis would transfer to the discrimination of shapes with different orientation of symmetry axis, or to shapes presented in different areas of the visual field. We found that there was no learning transfer between forms with very different axes of symmetry (90° apart). Interestingly, however, we found a transfer of learning effect to horizontally oriented symmetry axis from a condition with an axis of symmetry differing by 45°. Also it appears that some subjects took a longer time to learn than the typical fast learning paradigm would predict. Data showed that when observers practice discrimination of meaningless symmetric forms, consistent improvement in the performance occurs. This improvement is lasting over days, and it tends to be specific for the area of the visual field trained. We will discuss results from some of the observers whose learning was not fast, but who actually improved with more practice and with large time intervals (1 day) between training sessions.     

A double-blind,sham-controlled,trial of home-administered rhythmic 10-Hz median nerve stimulation for the reduction of tics,and suppression of the urge-to-tic,in individuals with Tourette syndrome and chronic tic disorder

Tourette syndrome (TS) and chronic tic disorder (CTD) are neurological disorders of childhood onset characterized by the occurrence of tics; repetitive, purposeless, movements or vocalizations of short duration which can occur many times throughout a day. Currently, effective treatment for tic disorders is an area of considerable unmet clinical need. We aimed to evaluate the efficacy of a home-administered neuromodulation treatment for tics involving the delivery of rhythmic pulse trains of median nerve stimulation (MNS) delivered via a wearable ‘watch-like’ device worn at the wrist. We conducted a UK-wide parallel double-blind sham-controlled trial for the reduction of tics in individuals with tic disorder. The device was programmed to deliver rhythmic (10 Hz) trains of low-intensity (1–19 mA) electrical stimulation to the median nerve for a pre-determined duration each day, and was intended to be used by each participant in their home once each day, 5 days each week, for a period of 4 weeks. Between 18th March 2022 and 26th September 2022, 135 participants (45 per group) were initially allocated, using stratified randomization, to one of the following groups; active stimulation; sham stimulation or to a waitlist (i.e. treatment as usual) control group. Recruited participants were individuals with confirmed or suspected TS/CTD aged 12 years of age or upward with moderate to severe tics. Researchers involved in the collection or processing of measurement outcomes and assessing the outcomes, as well as participants in the active and sham groups and their legal guardians were all blind to the group allocation. The primary outcome measure used to assess the ‘offline’ or treatment effect of stimulation was the Yale Global Tic Severity Scale–Total Tic Severity Score (YGTSS–TTSS) assessed at the conclusion of 4 weeks of stimulation. The primary outcome measure used to assess the ‘online’ effects of stimulation was tic frequency, measured as the number of tics per minute (TPM) observed, based upon blind analysis of daily video recordings obtained while stimulation was delivered. The results demonstrated that after 4-week stimulation, tic severity (YGTSS-TTSS) had reduced by 7.1 points (35 percentile reduction) for the active stimulation group compared to 2.13/2.11 points for the sham stimulation and waitlist control groups. The reduction in YGTSS–TTSS for the active stimulation group was substantially larger, clinically meaningful (effect size = .5) and statistically significant (p = .02) compared to both the sham stimulation and waitlist control groups, which did not differ from one another (effect size = −.03). Furthermore, blind analyses of video recordings demonstrated that tic frequency (tics per minute) reduced substantially (−15.6 TPM) during active stimulation compared to sham stimulation (−7.7 TPM). This difference represents a statistically significant (p < .03) and clinically meaningful reduction in tic frequency (>25 percentile reduction: effect size = .3). These findings indicate that home-administered rhythmic MNS delivered through a wearable wrist-worn device has the potential to be an effective community-based treatment for tic disorders.     

The Processing of Coreference for Reduced Expressions in Discourse Integration

Three reading-time experiments in Chinese are reported that test contrasting views of how pronominal coreference is achieved. On the one hand, studies of reading time and eye tracking suggest that reduced expressions, such as the pronoun he, serve as critical links to integrate separate utterances into a coherent model of discourse. On the other hand, probe-word recognition studies indicate that full anaphoric expressions, such as a repeated name, are more readily interpreted than reduced expressions due to their rich lexical information, which provides effective cues to match the representation of the appropriate referent in memory. The results indicate that the ease of integrating the critical referent into a model of discourse is a function of the congruence of lexical, semantic, and discourse features conveyed by a syntactically prominent reduced expression within linguistic input. This pattern supports the view that a reduced expression is interpreted on-line and indeed plays a critical role in promoting discourse coherence by facilitating the semantic integration of separate utterances.     

Executive Cognitive Function as a Correlate and Predictor of Child Food Intake and Physical Activity

Investigated were relations among executive cognitive function (ECF), food intake, and physical activity in 184, fourth grade children. It was hypothesized that self-reported ECF proficiency would predict greater self-reported fruit/vegetable intake and physical activity, but less “snack food” intake. Structural models demonstrated that ECF was significantly correlated with less concurrent snack food intake and greater concurrent fruit/vegetable intake, but not physical activity. Baseline ECF also significantly predicted greater fruit/vegetable intake and physical activity four months later, but not snack food intake. One implication is to promote ECF as a correlate and predictor of food intake and physical activity in children by providing opportunities for youth to practice newly developing ECF capacities.     

Childhood attachment to parents and frequency of prayer during the college years

This study examines the association between childhood attachment with parents and the frequency of prayer among people raised in Mormon families. Three types of attachment with fathers and mothers – secure, anxious, and avoidant – were measured on a Likert scale. Undergraduate students at a state university in Utah completed questionnaires that included measurements of childhood attachment with parents and frequency of prayer. According to bivariate correlations, frequency of prayer was related to the nature of childhood attachment to parents; according to multiple regression analyses, the correlation between frequency of prayer and childhood attachment was largely, but not entirely, accounted for by other factors involving general frequency of religious activity; finally, these results differed somewhat between men and women. Men who had an avoidant relationship with their mother in childhood prayed less often when they were in college, while for women this association was not statistically significant.