Treatment of bipolar depression

Bipolar disorder is underdiagnosed and often mistaken for unipolar depression. Bipolar patients spend 33% of their time in a state of depression compared to 11% of time spent in a manic state. Duration of time depressed and severity of depression are associated with increased risk for suicide, which occurs in 10% to 20% of bipolar patients. Antidepressants are increasingly being used as adjuncts in the depressed phase of bipolar disorder, although they provide a moderate risk for switch into mania. Lithium and some antiepileptics and atypical antipsychotics have shown antidepressant effects in the treatment of bipolar disorder. Other adjuncts for treatment-refractory patients include monoamine oxidase inhibitors and electroconvulsive therapy.     

An examination of the roles of trauma exposure and posttraumatic stress disorder on emotion regulation strategies of Operation Iraqi Freedom,Operation Enduring Freedom,and Operation New Dawn veterans

Theories of posttraumatic stress disorder (PTSD) implicate emotional processes, including difficulties utilizing adaptive emotion regulation strategies, as critical to the etiology and maintenance of PTSD. Operation Iraqi Freedom, Operation Enduring Freedom, and Operation New Dawn (OIF/OEF/OND) veterans report high levels of combat exposure and PTSD. We aimed to extend findings suggesting that emotion regulation difficulties are a function of PTSD, rather than combat trauma exposure or common comorbidities, to OIF/OEF/OND veterans, in order to inform models of PTSD risk and recovery that can be applied to returning veterans. We tested differences in emotion regulation, measured with the Difficulties in Emotion Regulation Scale and Emotion Regulation Questionnaire, among trauma-exposed veterans with (n = 24) or without PTSD (n = 22) and healthy civilian comparison participants (n = 27) using multivariate analyses of covariance, adjusting for major depressive disorder, anxiety disorders, and demographic variables (age, sex, and ethnicity). Veterans with PTSD reported more use of expressive suppression and more difficulties with emotion regulation than veterans without PTSD and healthy comparison participants. Groups did not differ on cognitive reappraisal. Findings suggest the key role of PTSD above and beyond trauma exposure, depression, and anxiety in specific aspects of emotion dysregulation among OIF/OEF/OND veterans. Interventions that help veterans expand and diversify their emotion regulation skills may serve as helpful adjunctive treatments for PTSD among OIF/OEF/OND veterans.     

Analyticity,Balance and Non-admissibility of $$\varvec{Cut}$$ Cut in Stoic Logic

Studia Logica - This paper shows that, for the Hertz–Gentzen Systems of 1933 (without Thinning), extended by a classical rule T1 (from the Stoics) and using certain axioms (also from the...     

Motivated gratitude and the need to belong: Social exclusion increases gratitude for people low in trait entitlement

Motivation and Emotion - Three studies examined effects of social exclusion on reactions to receiving an unexpected gift. Trait Psychological Entitlement was also measured as a potential moderator...     

Smartfounding: Four Grades of Resistance to Thought Experiments

Smartfounding is the opposite of “dumbfounding” introduced by Jonathan Haidt’s research on disgust. Dumbfounders have general competence at thought experiment (in contrast to people who lack formal education). However, they are flustered by thought experiments that support repugnant conclusions. Instead of following the supposition wherever it leads, they avoid unsettling implications by adding extraneous information or ignoring stipulated conditions. The dumbfounded commit performance errors, often seeming to regress to the answers of people who lack formal schooling. Smartfounders retain their composure. They practice subversive compliance, obeying the instructions in a way that spoils the aim of the thought experiment. Smartfounders offer a more sophisticated grade of resistance to thought experiment. Whereas the lower grades of resistance are merely fallacious, smartfounding often constitutes a penetrating internal critique of the thought experiment and sometimes of thought experiments in general.

     

Meaning in life and adjustment to daily stressors

People perceive their life as meaningful when they find coherence in the environment. Given that meaning of life is tied to making sense of life events, people who lack meaning would be more threatened by stressful life events than those with a strong sense of meaning in life. Four studies demonstrated links between perceptions of life’s meaningfulness and perceived levels of stress. In Study 1, participants with lower levels of meaning in life reported greater stress than those who reported higher meaning in life. In Study 2 and Study 3, participants whose meaning in life had been threatened experienced greater stress than those whose meaning in life had been left intact. In Study 4, anticipation of future stress caused participants to rate themselves higher on the quest for meaning in life. These findings suggest that perceiving life as meaningful functions as a buffer against stressors.     

Working mechanisms of a web-based self-management intervention for cancer survivors: a randomised controlled trial

Objective: The aim of this study was to investigate whether problem-solving skills and perceived personal control over cancer recovery mediated the intervention effects on depression and fatigue of a web-based computer-tailored intervention for cancer survivors – the Kanker Nazorg Wijzer (Cancer Aftercare Guide).

Design: Patients were recruited through 21 Dutch hospitals (November 2013–June 2014). The mediation model was tested in a randomised controlled trial with an intervention group (n = 231) and a waiting list control group (n = 231).

Main outcome measures: Hypothesised mediators problem-solving skills (SPSI-R) and personal control (IPQ-R) were measured at baseline and 3 months from baseline. Outcomes depression (HADS) and fatigue (CIS) were measured at baseline and 6 months from baseline.

Results: The intervention effects in decreasing depression and fatigue were mediated by personal control. Problem-solving skills did not mediate the intervention effects on depression and fatigue.

Conclusion: While personal control in the control group decreased in the first three months after baseline, levels of personal control within the intervention group were maintained. This effect partially explained the intervention effects on depression and fatigue. The results provide evidence for the relevance of addressing personal control in web-based interventions in order to improve psychosocial well-being in early cancer survivors.