排序方式: 共有131条查询结果,搜索用时 15 毫秒
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Yang J Hou C Ma N Liu J Zhang Y Zhou J Xu L Li L 《Neurobiology of learning and memory》2007,87(2):257-263
Prenatal stress can cause long-term effects on cognitive functions in offspring. Hippocampal synaptic plasticity, believed to be the mechanism underlying certain types of learning and memory, and known to be sensitive to behavioral stress, can be changed by prenatal stress. Whether enriched environment treatment (EE) in early postnatal periods can cause a recovery from these deficits is unknown. Experimental animals were Wistar rats. Prenatal stress was evoked by 10 foot shocks (0.8 mA for 1s, 2-3 min apart) in 30 min per day at gestational day 13-19. After weaning at postnatal day 22, experimental offspring were given the enriched environment treatment through all experiments until tested (older than 52 days age). Electrophysiological and Morris water maze testing was performed at 8 weeks of age. The results showed that prenatal stress impaired long-term potentiation (LTP) but facilitated long-term depression (LTD) in the hippocampal CA1 region in the slices. Furthermore, prenatal stress exacerbated the effects of acute stress on hippocampal LTP and LTD, and also impaired spatial learning and memory in the Morris water maze. However, all these deficits induced by prenatal stress were recovered by enriched environment treatment. This work observes a phenomenon that may contribute to the understanding of clinically important interactions among cognitive deficit, prenatal stress and enriched environment treatment. Enriched environment treatment on early postnatal periods may be one potentially important target for therapeutic interventions in preventing the prenatal stress-induced cognitive disorders. 相似文献
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考察了复杂物理问题解决中图形线索提示和参数线索提示的作用,结果表明,在难度较大的物理问题中,单一的图形线索提示未给学生带来太大的帮助,而参数线索提示有助于学生搜索到有效算子.讨论了专家在物理问题解决过程中的特点,认为专家的优势之一在于比新手更善于发现关键的线索,能够根据关键线索找到合适的原理来完整地表征问题. 相似文献
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该研究的两个实验采用心理不应期范式,探讨了重叠任务情境下双任务的相互干扰机制。实验中被试相继完成高低音的辨别任务(T1)和汉字外在特征(颜色或笔画数)的任务判断(T2),T1和T2间采用变化的SOA。结果发现:(1)T1的反应选择导致T2的加工成绩大幅下降,PRP效应非常显著。(2)当T1占据中枢瓶颈时,T2和T1在中枢瓶颈中并行得到加工并导致T1的加工效率显著下降。(3)由于注意资源的有限性,具有自动激活特征的汉字同样受瓶颈机制的限制。只要存在对注意资源的二次分配就会存在瓶颈的调节机制。 相似文献
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本研究采用主—客体互倚模型(actor-partner interdependence model,APIM)的方法深入探讨夫妻的依恋风格、婚姻归因与自身及配偶感知到的婚姻质量之间的关系。以方便取样的方式在北京地区选取155对夫妻,采用Brennan等(1998)编制的亲密关系经历量表(ECR),Stander编制的婚姻归因量表(MAQ)和Spanier编制的婚姻质量问卷(DAS),要求夫妻双方分别报告其依恋风格、婚姻归因方式和感知到的婚姻质量。通过配对t检验、相关分析和结构方程模型分析发现:(1)夫妻对婚姻质量的总体知觉较为一致,但丈夫的婚姻满意度显著高于妻子;(2)夫妻双方在回避依恋和焦虑依恋两个分量表上不存在显著差异,但在婚姻归因上,妻子比丈夫表现出了更多的消极归因;(3)妻子的消极依恋显著地负向预测自身感知到的婚姻质量,而丈夫的消极依恋对自身感知到的婚姻质量没有显著影响;(4)在控制了丈夫、妻子的依恋风格、归因方式对其自身婚姻质量的主体效应之后,丈夫的依恋风格不能显著预测妻子感受到的婚姻质量,但其归因方式可以显著地预测妻子感受到的婚姻质量;然而妻子的归因方式并不能显著预测丈夫的婚姻质量。 相似文献
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The argument from faultless disagreement employed by the relativist purports to show that contextualism falls short of explaining cases of faultless disagreement. The demonstration is intended to give credence to the relativist semantics of epistemic modality expressions. In this paper we present some cases showing that even though cases of faultless disagreement do reveal some intrinsic features of epistemic modality claims, they do not support the relativist semantics. The sophistication of faultless disagreement goes beyond what the relativist semantics can cope with. We also advance an epistemologically oriented proposal to account for faultless disagreement. 相似文献
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