Genetic associations of alcohol dehydrogenase with alcohol use disorders and endophenotypes in white college students

Associations of alcohol dehydrogenase (ADH) gene polymorphisms (ADH1B*2 and ADH1C*1) with a lifetime alcohol use disorder (AUD) were examined in White college students. Alcohol-related endophenotypes likely to be influenced by elevations in acetaldehyde were also assessed. Individuals with an ADH1B*2 allele had lower rates of AUDs, consumed a lower maximum number of drinks in a 24-hr period, reported a greater level of response to alcohol, were more likely to have experienced alcohol-induced headaches following 1 or 2 drinks, and reported more severe hangovers than those lacking this allele. These findings are consistent with the hypothesis that enhanced sensitivity to alcohol and lower levels of alcohol use reflect the mechanism by which ADH1B*2 protects against developing an AUD.     

Critical phenomenology and psychiatry

Continental Philosophy Review - Whereas classical Critical Theory has tended to view phenomenology as inherently uncritical, the recent upsurge of what has become known as critical phenomenology...     

Attachment in Psychotherapy

Abstract

Basic psychotherapy techniques are necessary for trauma intervention, including the terrorist attacks that occurred on September 11, 2001. The importance of these techniques is reviewed within various settings in the New York City area immediately following the World Trade Center disaster. The purpose included debriefing of practitioners, as well as the education of trauma symptoms and assessment for client intervention. Perhaps most importantly was the therapeutic technique modeled by the social work leader in these vignettes, since she and other practitioners simultaneously experienced symptoms of trauma. The practice of creating and maintaining a therapeutic atmosphere at this time was an essential challenge for all.     

framing of prenatal screening test results and women's health-illness orientations as determinants of perceptions of fetal health and approval of amniocentesis

Abstract

Framing effects of medical test results and interactions of these effects with personal perspectives were investigated in the context of prenatal screening. Hundred and Thirty-three pregnant women undergoing the ‘triple-test’ were assessed as having health or illness orientations, and were randomly presented with reassuring/moderate/severe diagnoses framed in normal/abnormal terms, forming a 2 × 3 × 2 between subjects design. Evaluations of fetus' health and recommendations to perform amniocentesis were assessed. Findings showed healthier evaluations of the fetus and weaker recommendations to perform amniocentesis in normal versus abnormal framings. An interaction was found between framing, diagnosis, and personal orientations: women with health orientations receiving a moderate diagnosis framed in abnormal terms were significantly more inclined to recommend amniocentesis than illness-oriented women given the same diagnosis; the normal/abnormal framing of severe diagnoses yielded opposite effects on health-oriented versus illness-oriented women. The influences of framing effects and health/ illness orientations on health perceptions and behavioral intentions were discussed.     

Adapted to explore: Reinforcement learning in Autistic Spectrum Conditions

Recent studies have recorded a tendency of individuals with Autism Spectrum Conditions (ASC) to continually change their choices in repeated choice tasks. In the current study we examine if this finding implies that ASC individuals have a cognitive style that facilitates exploration and discovery. Six decision tasks were administered to adolescents with ASC and matched controls. Significant differences in shifting between choice options appeared in the Iowa Gambling task (Bechara, Damasio, Damasio, & Anderson, 1994). A formal cognitive modeling analysis demonstrated that for about half of the ASC participants the adaptation process did not conform to the standard reinforcement learning model. These individuals were only coarsely affected by choice-outcomes, and were more influenced by the exploratory value of choices, being attracted to previously un-explored alternatives. An examination of the five simpler decision tasks where the advantageous option was easier to determine showed no evidence of this pattern, suggesting that the shifting choice pattern is not an uncontrollable tendency independent of task outcomes. These findings suggest that ASC individuals have a unique adaptive learning style, which may be beneficial is some learning environment but maladaptive in others, particularly in social contexts.     

Nordic Society for Phenomenology

Continental Philosophy Review -     

Steven Galt Crowell,Husserl, Heidegger,and the Space of Meaning: Paths toward Transcendental Phenomenology

Continental Philosophy Review -     

Self-projection in younger and older adults: a study of episodic memory,prospection, and theory of mind

Self-projection is the ability to orient the self in different places in time and space. Episodic memory, prospection, and theory of mind (ToM) are all cognitive abilities that share an element of self-projection. Previous research has posited that each of these abilities stems from the same neural network. The current study compared performance of cognitively healthy older adults and younger adults on several self-projection tasks to examine the relatedness of these constructs behaviorally. Episodic memory and prospection were measured using an episodic interview task where the participants were asked to remember or imagine events that either had happened in the past or could happen in the future and then gave ratings describing the extent to which they were mentally experiencing the event and from what perspective they viewed it. ToM was measured by asking participants to make judgments regarding the intentions of characters described in stories that involved cognitive, affective, or ironic components. Our results demonstrate that aging influences episodic memory, prospection, and ToM similarly: older adult participants showed declines on each of these measures compared to younger adults. Further, we observed correlations between performance on the measures of episodic memory and prospection as well as between episodic memory and ToM, although no correlation between prospection and ToM was observed after controlling for chronological age. We discuss these results in the light of theories suggesting that each of these abilities is governed by a common brain system.     

Who deserves to be sick? An exploration of the relationships between belief in a just world, illness causal attributions and their fairness judgements

This research explored relationships between beliefs about justice, illness causal attributions and fairness judgements of those causes. Participants (n?=?200) completed questionnaires assessing their belief in a just world (BJW) and measuring causal attributions and fairness judgements for 42 illness causes classified into behavioural, environmental and hidden (genetic, mystic, psychosocial) categories. As predicted, BJW was correlated positively with all fairness judgements, but with none of the illness causal attributions. Behavioural causes of illness were judged to be fairer than environmental causes, which were judged fairer than hidden causes. Finally, for environmental and hidden causes (uncontrollable illness attributions), positive correlations between causal attributions and their corresponding fairness judgements were found only among participants with high BJW. Implications of these findings for decision makers and health professionals are discussed, with emphasis on the need to consider the combined effect of causal attributions and BJW on illness fairness judgements.     

Factor and subtest discrepancies on the differential ability scales: examining prevalence and validity in predicting academic achievement

Past literature has largely ignored the population frequency of multivariate factor and subtest score discrepancies. Another limitation has been that statistical models imperfectly model the clinical assessment process, whereby significant discrepancies between both factors and subtests are included in predictions about an individual's academic achievement. The present study examined these issues using a nationally representative sample (N = 1,185) completing the Differential Ability Scales. Results indicate that approximately 80% of children in a nonreferred sample show at least one statistically significant ability discrepancy. In addition, the global estimate of cognitive ability was the most parsimonious predictor of academic achievement, whereas information about ability discrepancies did not significantly improve prediction. Findings suggest that when predicting academic achievement, there is little value in interpreting cognitive scores beyond the global ability estimate.