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Nima Motamed Shiva Edalatian Zakeri Behnam Rabiee Mansooreh Maadi Mahmood Reza Khonsari Hossein Keyvani Seyed Hamzeh Hosseini Farhad Zamani 《Applied research in quality of life》2018,13(2):303-316
Mental health is a key component of general health based on world health organization (WHO) definition of health. A short form of the general health questionnaire (GHQ-12) has been widely used as an assessment tool of general and mental health. This study was designed to evaluate the properties of the Persian version of this questionnaire. Of 6140 subjects aged 10–90 years of a cohort study of Northern Iran, the relevant data of 5074 individuals aged ≥18 years were considered for analysis. Confirmatory factor analysis was conducted to evaluate the six models including one-dimensional model, one-dimensional model with correlated errors on negative items, two-dimensional model based on negative and positive statement items, two-dimensional model based on social dysfunction and psychological distress, three-dimensional model based on anxiety/depression, social dysfunction and loss of confidence and finally one-dimensional model with an additional factor for the negatively phrased items. The best fit indices belonged to one-dimensional model with correlated errors on negative items with χ2 = 686.8, df = 39, CFI = 0.953, RMSEA = 0.057 (95%CI: 0.054–0.061), SRMR = 0.0317, AGFI = 0.952, TLI = 0.920 and AIC = 764.8 and also three-dimensional model with χ2 = 860.7, df = 51, CFI = 0.941, RMSEA = 0.056 (95%CI: 0.053–0.059), SRMR = 0.0343, AGFI = 0.955, TLI = 0.923 and AIC = 915.0. In the comparison between these two best models we had ?χ2 = 174.2, ?df = 12, p-value < 0.001 in favor of the one-dimensional model. One-dimensional model with correlated errors on negative items showed the best fitting indices with our population. 相似文献
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Caryn Lerman Peter G Shields E Paul Wileyto Janet Audrain Larry H Hawk Angela Pinto Susan Kucharski Shiva Krishnan Ray Niaura Leonard H Epstein 《Health psychology》2003,22(5):541-548
This study examined the role of dopaminergic genes in prospective smoking cessation and response to bupropion treatment in a placebo-controlled clinical trial. Smokers of European ancestry (N=418) provided blood samples for genetic analysis and received either bupropion or placebo (10 weeks) plus counseling. Assessments included the dopamine D2 receptor (DRD2) genotype, dopamine transporter (SLC6A3) genotype, demographic factors, and nicotine dependence. Smoking status was verified at the end of treatment (EOT) and at 6-month follow-up. The results provided evidence for a significant DRD2 * SLC6A3 interaction effect on prolonged smoking abstinence and time to relapse at EOT, independent of treatment condition. Such effects were no longer significant at 6-month follow-up, however. These results provide the first evidence from a prospective clinical trial that genes that alter dopamine function may influence smoking cessation and relapse during the treatment phase. 相似文献