PACAP centrally mediates emotional stress-induced corticosterone responses in mice

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide widely distributed in the nervous system. Recently, PACAP was shown to be involved in restraint stress-induced corticosterone release and concomitant expression of the genes involved in hypothalamic-pituitary-adrenal (HPA) axis activation. Therefore, in this study, we have addressed the types of stressors and the levels of the HPA axis in which PACAP signaling is involved using mice lacking PACAP (PACAP?/?). Among four different types of stressors, open-field exposure, cold exposure, ether inhalation, and restraint, the corticosterone response to open-field exposure and restraint, which are categorized as emotional stressors, but not the other two, was markedly attenuated in PACAP?/? mice. Peripheral administration of corticotropin releasing factor (CRF) or adrenocorticotropic hormone induced corticosterone increase similarly in PACAP?/? and wild-type mice. In addition, the restraint stress-induced c-Fos expression was significantly decreased in the paraventricular nucleus (PVN) and medial amygdala (MeA), but not the medial prefrontal cortex, in PACAP?/? mice. In the PVN of PACAP?/? mice, the stress-induced c-Fos expression was blunted in the CRF neurons. These results suggest that PACAP is critically involved in activation of the MeA and PVN CRF neurons to centrally regulate the HPA axis response to emotional stressors.     

Spontaneous versus Controlled Influences of Stimulus-Based Affect on Choice Behavior

This article identifies two routes through which affect and cognitions arising from a stimulus can influence choices: a “lower order” route, where choices are influenced through automatic affective processes, and a “higher order” route, where choices are influenced through more controlled affective or consequence-related cognitive processes. Across three experiments the extent of deliberation, mental preoccupation, and the nature of exposure to the stimuli were manipulated to identify conditions under which lower order affect, higher order affect, or higher order cognitions impact choices. Respondents chose between two alternatives: one that was associated with more intense positive affect but less favorable cognitions (e.g., chocolate cake), and one that was associated with less intense positive affect but more favorable cognitions (e.g., fruit salad). Findings suggest that when the individual makes the decision quickly and is mentally preoccupied while making the decision, choices are driven by lower order affect. When the individual deliberates on the decision without being mentally preoccupied and the affect-laden option is in full view while the decision is being deliberated upon, choices are driven by higher order affect. In both cases, the affect-laden option (e.g. chocolate cake) is selected. In all other situations, choices are driven by higher order consequence-related cognitions and the alternative that is superior on the cognitive dimension (e.g. fruit salad) is selected. It is suggested that the effects of affective reactions on choice occur through the activation of appetitive (i.e., gratification-seeking) goals.     

Alexithymia and sociocultural factors in a Japanese sample: a study with the Rorschach

We reexamined the Japanese version of the 20-item Toronto Alexithymia Scale, a self-report sc ale for measuring alexithymic characteristics, by comparing the scores on three factors and the total scores with variables of the Rorschach in a sample of 40 (originally 48) Japanese college students. Based on prior studies, our aims were to further validate the 20-item Toronto Alexithymia Scale by comparing its scores with those on a projective technique. We also investigated whether sociocultural factors, such as repression of hostility. are associated with scores on the 20-item Toronto Alexithymia Scale (especially Factor 3). None of the seven Rorschach Alexithymia Variables were significantly related to the factors and total scores of the 20-item Toronto Alexithymia Scale. However, scores for Factor 1 (difficulty identifying feelings) of the 20-item Toronto Alexithymia Scale correlated positively with scores on Sum C' (reserved responses to emotional stimuli) and Adj es (stimulus demand), suggesting that individuals who score high for Factor 1 experience gloomy, depressive feelings but in constricted ways. Scores for Factor 3 (externally oriented thinking) correlated positively with the D scores (stress tolerance) and negatively with m (situational stress) responses, suggesting that Factor 3 may reflect a psychological defense that enhances stress tolerance. There was a nonsignificant negative correlation between Factor 1 and Factor 3 scores, but, unlike our hypothesis. Factor 3 was neither related to AG (aggression) nor S (space responses reflecting oppositional tendency), indices of aggression or hostility in the Rorschach Comprehensive System. It may be that the 20-item Toronto Alexithymia Scale and the Rorschach measure quite different aspects of personality, but further research is necessary.     

A “hand-shaking” multiplexer for the IBM 1800

An instrument is described which is used to multiplex the “ready” and “external sync” lines of an IBM 1800’s data channel to 15 external devices. Used with the digital output registers of the computer, the device facilitates the interfacing of non-IBM peripheral devices to the 1800. The multiplexer can be used in any application in which a pair of lines needs to be shared among several devices.     

Type-A Behavior, Job Performance, and Well-Being in College Teachers

This study examined the relationship between Type-A behavior and job performance, and employee well-being among college teachers in Canada. Well-being was operationalized in terms of burnout, social support, work satisfaction, and turnover motivation. Data were collected by means of a structured questionnaire from 420 college teachers. Pearson correlation and moderated multiple regressions were used to analyze the data. Global Type-A behavior was not related to 3 measures of job performance: teaching hours, number of course preparations per semester and number of students. However, global Type-A behavior correlated positively with burnout and turnover motivation and negatively with perceived social support and work satisfaction. Two components of Type-A behavior (time pressure and hard driving/competitiveness) exhibited the same pattern of relationship with job performance and well-being variables as was found with the global measure of Type-A behavior. Moderated multiple regression did not support the role of gender as a moderator of Type-A behavior and job performance and well-being variables.     

Timing and torque involvement in the organisation of a rapid forearm flexion

The study was designed to determine whether the magnitude of force and the timing of force are response parameters involved in the organisation of a rapid forearm flexion to a target. The magnitude of torque and the timing of torque were manipulated independently through manipulations of the total moment of inertia and movement time, and the effect of these manipulations on premotor and motor reaction times was observed. Planned comparison analyses revealed that premotor and motor reaction times increased when a movement, which required the same magnitude of torque as in a fast movement, was performed slower. However, premotor and motor reaction times were not affected when movements were performed at the same speed, but differed with respect to the magnitude of torque required. These results indicate that a different timing requirement in the forthcoming movement is associated with a corresponding change in the amount of central processing time required. Therefore, the timing of torque appears to be a parameter of the movement that is organised in advance of movement execution. However, a change in the specification for the magnitude of torque does not affect the amount of time needed to organise the movement.     

Emotions Know Best: The Advantage of Emotional versus Cognitive Responses to Failure

Making mistakes or failing at tasks is a common occurrence in human life. People can respond to and cope with failure in many ways. In this research, we examine potential advantages of relatively emotional (versus cognitive) responses to failure. In particular, we study how effort and time spent in subsequent tasks depend on whether people predominantly focus on their emotions or their cognitions as they respond to a failure. We demonstrate that, left to their own means, people's cognitions upon a failure are mainly justificatory in nature and thus do not automatically have the commonly believed reflective, self‐improving qualities. We further argue and demonstrate that a relative focus on cognitions following a failure can prevent improvement in subsequent episodes, but a focus on emotions can allow for learning and, therefore, increased effort. Copyright © 2017 John Wiley & Sons, Ltd.