Galantamine facilitates acquisition of a trace-conditioned eyeblink response in healthy, young rabbits

Previous work has demonstrated that drugs increasing brain concentrations of acetylcholine can enhance cognition in aging and brain-damaged organisms. The present study assessed whether galantamine (GAL), an allosteric modulator of nicotinic cholinergic receptors and weak acetylcholinesterase inhibitor, could improve acquisition and retention of an eyeblink (EB) classical conditioning task in healthy, young animals. We trained 24 rabbits (n = 8/group) in a 1000-msec trace Pavlovian EB conditioning paradigm in which a tone conditioned stimulus (CS) was presented for 500 msec, followed by a 500-msec trace period in which no stimuli were presented. A 100-msec corneal airpuff was the unconditioned stimulus (US). Acquisition sessions, consisting of 100 trials each, occurred daily for 10 consecutive days, followed by 3 d of extinction training. Animals were treated with one of three doses of GAL (0.0-3.0 mg/kg) prior to each session. Animals that received 3.0 mg/kg GAL showed significantly more EB conditioned responses (CRs) in fewer training trials than animals receiving either 1.5 mg/kg GAL or vehicle injections. GAL had no effect on CR performance during extinction. Pseudoconditioning control experiments, consisting of 200 explicitly unpaired tone-puff presentations indicated that GAL did not increase reactivity to the CS or US. These findings indicate that GAL may improve acquisition of moderately difficult associative learning tasks in healthy young organisms.     

The role of atypical antipsychotics in glucose/insulin dysregulation and the evolving role of the psychiatrist in a new era of drug treatment options

This article examines the issue of atypical antipsychotics, glucose/insulin, and other metabolic derangements (ie, metabolic syndrome), including a general introduction to the health concerns of our patients, a review of the literature, possible mechanisms of antipsychotic induced glucose dysregulation, monitoring approaches, and management and prevention of metabolic syndrome. Literature review leads to mechanism hypotheses and risk estimations, leading to guidelines for monitoring and treatment. The patient population suffers from a higher degree of baseline metabolic dysregulation resulting in cardiovascular disease through components of the metabolic syndrome, and this risk increases with administration of atypical antipsychotic medication at different rates, depending on both drug and patient risk factors. The growing knowledge of mechanisms behind drug induced glucose/insulin and other metabolic dysregulation, as well as advances in pharmacogenomics, will help refine drug selection and monitoring for adverse, life-threatening metabolic effects.     

Evaluating the success of Caucasian fathers in guiding adolescents

The purpose of this study was to identify guidance strengths and learning needs of fathers of adolescents. Perceptions of two generations were used to determine how well fathers perform as parents and realms of knowledge they have yet to acquire. The Parent Success Indicator, a 60-item Likert-type instrument, was administered to 126 Caucasian fathers and 185 adolescents. Significant differences obtained between generations for the total inventory, some scales, and many items. The amount of time spent together had the greatest influence on how both generations evaluated father success. Findings are discussed in terms of developing a curriculum to enhance the success of fathers.     

The treatment of sexual dysfunction: Some theoretical considerations

Journal of Contemporary Psychotherapy -     

Dissimilar items benefit from phonological similarity in serial recall

In short-term serial recall, similar sounding items are remembered less well than items that do not sound alike. This phonological similarity effect has been observed with lists composed only of similar items, and also with lists that mix together similar and dissimilar items. An additional consistent finding has been what the authors call dissimilar immunity, the finding that ordered recall of dissimilar items is the same whether these items occur in pure dissimilar or mixed lists. The authors present 3 experiments that disconfirm these previous findings by showing that dissimilar items on mixed lists are recalled better than their counterparts on pure lists if order errors are considered separately from intrusion errors (Experiment 1), or if intrusion errors are experimentally controlled (Experiments 2 and 3). The memory benefit for dissimilar items on mixed lists poses a challenge for current models of short-term serial recall.     

Psychoanalytic supervision of the difficult patient

Control cases from the broad group of non-neurotic but potentially analyzable patients appear with increasing frequency. The intense, complex transferences they develop place great stress on the psychoanalytic relationship and evoke marked countertransference reactions in psychoanalytic candidates, which reverberate within the supervisory relationship. Through application of a case study method, common themes emerge in the candidate-supervisor dyad: idealization of the supervisor and of classical technique, identification with the patient, parallel process enactments, difficulty maintaining the analytic frame, and the importance of concurrent training analysis. Classical supervisory techniques must be adapted to the "difficult" (non-neurotic) control case. Complex countertransference issues must be carefully addressed while maintaining the teach/treat boundary.     

The visual control of reaching and grasping: binocular disparity and motion parallax

The primary visual sources of depth and size information are binocular cues and motion parallax. Here, the authors determine the efficacy of these cues to control prehension by presenting them in isolation from other visual cues. When only binocular cues were available, reaches showed normal scaling of the transport and grasp components with object distance and size. However, when only motion parallax was available, only the transport component scaled reliably. No additional increase in scaling was found when both cues were available simultaneously. Therefore, although equivalent information is available from binocular and motion parallax information, the latter may be of relatively limited use for the control of the grasp. Binocular disparity appears selectively important for the control of the grasp.     

Respect for group members: intragroup determinants of collective identification and group-serving behavior

This experiment examined how (disrespectful vs. respectful) treatment and (negative vs. positive) performance evaluation, both received from the same fellow group members, affects collective identification and willingness to engage in group-serving behavior. It was predicted and found that respectful as opposed to disrespectful intragroup treatment increased collective identification and willingness to engage in group-serving behavior in the immediate group situation, irrespective of whether intragroup evaluation was positive or negative. There was also evidence of a mediating role of collective identification. Regression analyses based on the measurement of perceived intragroup treatment and perceived intragroup evaluation as continuous variables corroborated these findings but also pointed to limits of the positive effects of respectful intragroup treatment. Finally, the interrelation of treatment and evaluation by fellow group members as two possible components of intragroup respect are discussed as well as the political dimension of research on intragroup respect.