These experiments explore parallels between the neurobiological substrates of spatial and context learning. Male Long-Evans rats were employed in a context fear conditioning protocol that involved sequential acquisition and testing in two distinct contexts. Rats received three unsignaled footshocks in one context and were tested for context fear, measured as freezing, the next day. Four days later, the procedure was repeated in a different, distinct context. Rats received a hippocampal infusion of either the NMDA receptor antagonist 5-amino-phosphonovaleric acid (APV, 10 microg) or vehicle prior to training in each context. NMDA receptor blockade was effective in impairing context learning only in the first context. Context fear acquisition was not impaired by APV in the second context, indicating that pre-training (in the first context) mitigated the effects of APV. These data agree with those seen previously in the water maze, where pre-training prevented learning deficits produced by NMDA receptor blockade. The data thus suggest that the neurobiological substrates of context learning and place learning overlap. 相似文献
A relevant issue in the debate on continuous vs. discrete processing of information is whether incompletely processed information does or does not affect a subsequent reaction. Two stimuli (SL, SR) were presented on eye level, subtending a visual angle of 45 degrees. SL was always inspected first, followed by a saccade to SR and finally by a same/different response. The fixation time of SL (TL), the saccadic time (TM) and the time from fixating SR to the response (TR) were separately measured. SL and SR consisted of two-dimensional stimuli (size and letter shape) constructed in such a way that encoding size took longer for one group and encoding shape took longer for another group of 10 subjects. All subjects were tested in three conditions: Shape was relevant in one, size in the second, and both dimensions were relevant in the third condition.
TL was less when encoding the relevant dimension was fast. When both dimensions were relevant, TL was about as long as when only the slow dimension was relevant, suggesting parallel and interference-free processing during TL. When only the slow dimension was relevant, TR (same) was much longer when the fast dimension differed. When the fast dimension was relevant, TR (same) was slightly longer when the slow dimension differed, which can be handled by either model. The experiment was repeated with three well-practiced and less variable subjects who carried out sufficient trials to measure TR as a function of TL. The results of this study were in line with the discrete model: A different slow and irrelevant dimension did not affect the same response regardless of the duration of TL. Interestingly, subjects were capable of retrieving the slow dimension, suggesting a code which can be used for retrieval but which does not affect the same/different response. 相似文献
This article examines several measures used in the assessment of adult abuse and trauma. These measures include structured clinical interviews, self report measures, screening inventories, symptom checklists, and some measures that include decision-making properties. Specific conditions in the assessment of adult victims of psychological trauma and implications for clinical practice are explored.相似文献
Two experiments were performed which tested the type of information that can be extracted from the periphery of the visual field, i.e. content information or position information. In both studies two digits were compared, one presented at the left and one at the right of the subject's meridian, seperated by a binocular visual angle, comprising either an eye-field (45°) or a head-field display (100°). In the first experiment the right signal was presented in separate blocks of either degraded or undegraded digits. In the case of undegraded digits, processing efficiency was better in the eye-field than in the head-field. With degraded digits this eye-field advantage was significantly smaller, but did not altogether disappear, suggesting that information about both the content and the position of digits in the periphery is acquired in the eye-field as opposed to the head-field. In the second experiment degraded and undegraded digits occured randomly within the same block of trials. This was done to investigate whether peripheral information is acquired automatically or through controlled processing. The results indicate a small eye-field advantage, about equal for both degraded and undegraded digits. This supports the controlled processing hypothesis, at least with regard to the acquisition of content information from the periphery. 相似文献
Cortical electroencephalographic (EEG) changes induced by ethanol (4.3 and 1.4 g/kg, ip), pentobarbital (50 and 16 mg/kg), and nicotine (1.0 g/kg) were examined in long-sleep (LS) and short-sleep (SS) mice that were genetically selected for differential sleep times induced by a hypnotic dosage of ethanol. Ethanol (4.3 g/kg) caused EEG changes that paralleled the behavioral differences, whereas no differences between selected lines were observed following the activating dose (1.4 g/kg). Data support the notion that the known difference in ethanol sleep times is due not to greater SS sensitivity to ethanol activation but rather to greater LS sensitivity to ethanol hypnosis. No differences between selected lines were observed following 50 mg/kg pentobarbital, which again parallels previous behavioral data. The SS mice were more responsive to pentobarbital activation (16 mg/kg). Nicotine more severely reduced EEG power and heart rate in LS mice; a continuous iv infusion of nicotine elicited a distinct pattern of behavioral stereotypy for each selected line, with more profound motor and reflex depression in LS mice. The lines do not differ in rate of nicotine metabolism, hence they must differ in central nervous system sensitivity to nicotine. Thus, lines of mice selectively bred for differential sensitivity to ethanol also display marked differences in electrophysiological and behavioral responses to nicotine. 相似文献
A clear conflict exists between experiments showing either additive or interactive effects of foreperiod duration and S-R compatibility on choice reaction time. It is hypothesized that in principle S-R compatibility and foreperiod duration have additive effects but that the effect of foreperiod duration is reduced in conditions where a signal is immediately arousing and where the S-R relations are highly compatible. In the case of low S-R compatibility the effect of immediate arousal is supposed to be ineffective.This hypothesis is tested and confirmed in an experiment in which the combined effects of foreperiod duration and S-R compatibility were studied with either loud (85 dBA) or weak (45 dBA) auditory signals. As predicted, additive effects were found in the latter case, while an interaction was observed with 85 dBA signals. 相似文献
The purpose of the present study was to investigate four traditionally male occupations and four traditionally female occupations on a number of dimensions which people use to judge the prestige or importance of a job. Workers were pictured on one form in their traditional roles and on a second form in nontraditional roles. Results indicated a tendency for subjects to give lower ratings to workers in nontraditional jobs. More importantly, for the two “objective” dimensions, money and education, boys and girls agreed on job ratings; however, on the two more “subjective” dimensions, respect and importance to the community, boys gave higher ratings to the male jobs, while girls gave higher ratings to the female jobs. 相似文献