要注意中药对肝的损伤作用

含有生物碱类、皂苷类、萜类、毒蛋白类、重金属类成分的中药易致急性肝损伤.中药对肝脏损伤的原因及机制较为复杂,可能与药物对肝脏的直接毒性或特异性体质有关.此外,中药炮制方法、给药途径、剂型、剂量、疗程及配伍不当也会引起药物性肝损伤.中药所致的药物性肝损伤的诊断主要依据用药史、发病的时间、过程和临床表现并排除其他因素.治疗可选用还原型谷胱甘肽、S-腺苷蛋氨酸、多烯磷脂酰胆碱、熊去氧胆酸、水飞蓟素等药物,重症可选择人工肝脏支持治疗.     

阿尔茨海默病生物学标志物研究进展

阿尔茨海默病（AD）是常见的中枢神经系统变性疾病,是痴呆最常见的病因,发病率高.病理特征为老年斑及神经元纤维缠结.AD的确诊有赖病理学,临床诊断极其耗时.由于尚无准确的早期诊断方法,常使AD患者错过早期治疗的时机,这成为制约有效防控AD的瓶颈问题.因此寻找高敏感性、特异性、无创性的生物学标志物对AD的早期诊断至关重要.本文仅将目前较为广泛研究的生物学标志物及其研究现状作一概述.分别对脑脊液、血液、尿液及唾液中的AD标志物作逐一介绍.     

开腹手术后早期炎性肠梗阻的诊断与综合治疗

总结术后早期炎性肠梗阻的临床治疗经验及防治措施.回顾性分析36例腹部手术后早期炎性肠梗阻患者临床治疗方法.33例经非手术治疗治愈,平均治愈时间(15.5±9.5)d,1例自动出院,2例转往上级医院进一步治疗.腹部手术后早期炎性肠梗阻应以保守治疗为主,有效的治疗包括禁食、胃肠减压、全肠外营养支持、糖皮质激素和生长抑素的应用.炎性肠梗阻选择非手术治疗,既保证了治疗的有效性,同时也能够让患者接受.     

《管子》论“且怀且威”及其现代启示

《管子》认为,治理国家既要采用怀柔政策,主张为政者"先之以德",通过整饬四维来形成良好的社会风尚;又强调"法不可不审",主张通过严刑峻法来树立君主的权威,赏罚严明,使人们严格遵守各项法令制度,坚持"且怀且威",礼法并重,其思想对现代社会有很好的启迪意义。     

孔门三弟子比较论说

孔门十哲,出类拔萃者莫若颜回、子贡、子路,且此三人之身世、性情、才具、道德修为和成就各有风华,但又殊途同归：共同维护了孔门。光大了儒家。孔子称得上是中华民族几千年来最为伟大的教育家,颜回、子贡、子路三人各方面的修为和成就,莫不大大受惠于夫子有教无类、因材施教的卓越的教育理论和教育方式。三人也没有辜负孔子的教导,以身垂范,较好地诠释了孔子儒家所宣扬的“仁、智、勇”;并与其师一道,在乱世中矢志不渝,坚守道义,追求理想,为儒学的传播和繁荣做出了重要的贡献。     

Creative Scientific Problem Finding and Its Developmental Trend

This is a study of the development trend of creative scientific problem finding (CSPF) ability of a sample of 1,367 elementary, middle, and high school students in two Chinese cities. Students were instructed to generate science related questions in both open and closed conditions with responses scored for Fluency, Flexibility, and Originality. Results suggest that CSPF ability has a developmental trend characterized by a significant leap in the 5th grade, followed by a steady advance until it peaked in the 8th grade, and then declined and stabilized in the high school years (9th–11th grades). No difference between male and female students was found. The type of instruction showed significant differential influence on CSPF and its development.     

Too exhausted to remember: Ego depletion undermines subsequent event‐based prospective memory

Past research has consistently found that people are likely to do worse on high‐level cognitive tasks after exerting self‐control on previous actions. However, little has been unraveled about to what extent ego depletion affects subsequent prospective memory. Drawing upon the self‐control strength model and the relationship between self‐control resources and executive control, this study proposes that the initial actions of self‐control may undermine subsequent event‐based prospective memory (EBPM). Ego depletion was manipulated through watching a video requiring visual attention (Experiment 1) or completing an incongruent Stroop task (Experiment 2). Participants were then tested on EBPM embedded in an ongoing task. As predicted, the results showed that after ruling out possible intervening variables (e.g. mood, focal and nonfocal cues, and characteristics of ongoing task and ego depletion task), participants in the high‐depletion condition performed significantly worse on EBPM than those in the low‐depletion condition. The results suggested that the effect of ego depletion on EBPM was mainly due to an impaired prospective component rather than to a retrospective component.     

Exploring trust of mobile applications based on user behaviors: an empirical study

This paper explores trust of mobile applications based on users' behaviors. It proposes a trust behavior construct through principal component analysis, reliability analysis, and confirmatory factor analysis based on the data collected from a questionnaire survey with more than 1,500 participants. It is indicated that a user's trust behavior is composed of three principal constructs: using behavior, reflection behavior, and correlation behavior. They are further delineated into 12 measurable sub‐constructs and relate to a number of external factors. The data analysis showed that the questionnaire has positive psychometric properties with respect to construct validity and reliability. We also discuss the practical significance and limitations of our work toward usable trust management.     

Effects of Electromyostimulation on Knee Extensors and Flexors Strength and Steadiness in Older Adults

It is known that electromyostimulation (EMS) alone or superimposed over voluntary contraction (EV) can effectively improve muscle strength. However, the effect of this type of training on the ability to control force production at submaximal levels is unknown. The authors examined the effects of EV training on steadiness in force production of knee extensors and flexors in older adults. Forty participants, including 20 men and 20 women, 60–77 years of age, were randomly allocated into a control group (CG) and an electromyostimulation superimposed over voluntary contraction (EVG) group. The EVG performed 30 bilateral isometric knee extension and flexion contractions per session, 3 training sessions per week, for 6 weeks. The variations in force production, expressed in absolute (standard deviation [SD]) and relative (coefficient of variation [CV]) terms, were assessed in isometric contractions at 5%, 15% and 25% maximal voluntary contraction (MVC) levels. Results indicated that MVC increased in knee extension and flexion in EVG (p < .05) after the training; steadiness CV also improved at 15% MVC in knee flexion (p < .05) but no significant changes were found in knee extension and steadiness SD. The training-induced changes in MVC were not correlated to steadiness CV that might indicate different mechanisms underlying these adaptations.     

Bidirectional Mediating Role of Loneliness in the Association Between Shyness and Generalized Pathological Internet Use in Chinese University Students: A Longitudinal Cross-Lagged Analysis

Abstract

This 1-year longitudinal study examined the bidirectional mediating role of loneliness in the association between shyness and generalized pathological Internet use (GPIU) in a sample of 291 Chinese university students (143 men, mean age =?19.07?years). A fully cross-lagged panel design was used in which shyness, loneliness, and GPIU were assessed at 3 time points separated by 6-month intervals (named T1, T2, and T3). The results indicated that relationships among shyness, loneliness, and GPIU were dynamic and bidirectional. Specifically, T1 shyness positively predicted increased T2 loneliness, T2 shyness positively predicted increased T3 loneliness, and T2 loneliness positively predicted increased T3 shyness. Additionally, T1 GPIU positively predicted increased T2 loneliness, T2 GPIU positively predicted increased T3 loneliness, and T2 loneliness positively predicted increased T3 GPIU. Loneliness was found to play a bidirectional mediating role in the association between shyness and GPIU. Specifically, T1 shyness and T3 GPIU were mediated through increased loneliness at T2, and T1 GPIU and T3 shyness were mediated through increased loneliness at T2. Furthermore, relationships among shyness, loneliness, and GPIU were the same across the 2 groups, with the strength of relationships being stronger for men.