The Effects of Selective Cholinergic Basal Forebrain Lesions and Aging upon Expectancy in the Rat

The effects of selective cholinergic cell loss within the basal forebrain (BF) were determined using a task that requires shifting of attention between two visual stimuli. Discriminability between two stimuli and response bias were determined in young and old F-344 rats given BF injections of IgG-192 saporin (100 ng). The lesion reduced ChAT activity in the frontal and parietal cortices, hippocampus, and olfactory bulbs. The lesion did not significantly alter Na⁺/K⁺-ATPase activity in cortex, hippocampus, or olfactory bulbs, or endogenous levels of neuropeptide Y and neurokinin B within the BF. The BF lesions impaired both stimulus discriminability and response bias in young and old rats. The BF lesions had a significantly greater effect upon stimulus discriminability and response bias in aged rats, compared to young rats, only when the stimulus duration was very brief, i.e., when the task was most difficult to solve. At longer stimulus durations, aging and lesions showed no interaction. The results suggest that the selective loss of cholinergic cells in the BF, but not normal aging, impairs the ability to discriminate between independent sensory stimuli. The loss of these cells confers a response bias in simple operant tasks involving motor responses to reward-related visual stimuli.     

Solution-focused Couples Therapy Groups: An Empirical Study

The professional literature contains numerous theoretical and case study articles regarding the development and use of solution-focused therapy. However, as with many models of systems-oriented therapy in use with couples, very little has been subjected to empirical investigation. This project was designed to make a contribution to the empirical literature regarding the effectiveness of solution-focused therapy in use with couples' groups. This study utilized pre-test comparisons of treatment and comparison groups, and examined pre- to post-test changes in the scores of the treatment group couples. Twenty-three treatment group couples participated in a six-week solution-focused couples therapy (SFCT) group. A separate group of thirteen couples served as a comparison group. The Dyadic Adjustment Scale (DAS) was used to assess changes in the couples' relationships. Scores on the Marital Status Inventory (MSI), as a pre-test measure indicating the couples' likelihood of divorce, indicated no significant differences between groups. The remaining analyses revealed significant improvement in DAS scores. Self-reports from the couples involved indicate improvement in a variety of areas after completing the six-week solution-focused couples group therapy process.     

Probability spaces,hilbert spaces,and the axioms of test theory

A branch of probability theory that has been studied extensively in recent years, the theory of conditional expectation, provides just the concepts needed for mathematical derivation of the main results of the classical test theory with minimal assumptions and greatest economy in the proofs. The collection of all random variables with finite variance defined on a given probability space is a Hilbert space; the function that assigns to each random variable its conditional expectation is a linear operator; and the properties of the conditional expectation needed to derive the usual test-theory formulas are general properties of linear operators in Hilbert space. Accordingly, each of the test-theory formulas has a simple geometric interpretation that holds in all Hilbert spaces.     

Effects of different delay of reinforcement procedures on variable-interval responding

Two experiments studied responding in the rat when the first bar press after a variable period of time produced a cue light that remained on for either 10, 30, or 100 sec and terminated with the delivery of food. In Experiment I, response rate decreased and time to the first response after reinforcement increased as the delay of reinforcement increased. Similar results were obtained whether the delay consisted of retracting the lever during the delay, a fixed delay with no scheduled consequence for responding, or every response during the delay restarted the delay interval. In Experiment II, fixed-delay and fixed-interval schedules of the same duration during the delay period had no differential effect on either response rate or time to the first response after reinforcement, but differentially controlled responding during the delay periods.     

The spacing effect in the learning of word pairs

Following the presentation of a single list of word pairs consisting of a three-letter word on the left and a five-letter word on the right, groups of 64 Ss each were asked to recall the (a) three-letter words, (b) five-letter words, (c) intact pairs, or (d) five-letter words with the three-letter words provided. Two types of repeated pairs were presented, one in which the same three- and five-letter words were repeated together (same pairs) and one in which the same five-letter word was repeated with different three-letter words (different pairs). For half of the Ss in each recall group, the repetitions of a pair containing a given five-letter word were massed (MP); for the other half, the repetitions were distributed (DP). Recall of MP same pairs and the eomponents of these pairs was consistently poorer than that of DP same pairs. Recall of the repeated component of the different pairs was also poorer under MP than under DP. The results were interpreted as supportive of an attenuation-of-attention explanation of the spacing effect.     

Rate changes after unscheduled omission and presentation of reinforcement

Changes in response rate similar to frustration effects were studied in a two-lever situation. Responding on one lever on a fixed-interval schedule produced access to water for 5 sec and an exteroceptive stimulus. In the presence of this stimulus, responding on another lever on a fixed-interval schedule produced access to water for 5 sec and terminated the stimulus. Occasional omission of a previously scheduled reinforcer after responding on the first lever resulted consistently in increases in rate on the second lever during the immediately succeeding interval. In another procedure, occasional presentation of a previously unscheduled reinforcer after responding on the first lever resulted consistently in decreases in rate on the second lever during the immediately succeeding interval. Changes occurred after the first omissions or presentations and were about the same in magnitude as the procedure continued over several sessions. Typically, an increase or decrease in rate was maintained throughout an entire 100-sec interval. Changes in rate on the second lever of approximately the same magnitude also occurred when rate on the first lever was near-zero under a schedule that differentially reinforced behavior other than lever pressing.