Role of the NO/sGC/PKG signaling pathway of hippocampal CA1 in morphine-induced reward memory

Evidence suggests that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP dependent protein kinase (PKG) signaling pathway plays a key role in memory processing, but the actual participation of this signaling cascade in the hippocampal CA1 during morphine-induced reward memory remains unknown. In this study, we investigated the role of the NO/sGC/PKG signaling pathway in the CA1 on morphine-induced reward memory using a conditioned place preference (CPP) paradigm. We found that rats receiving an intraperitoneal (i.p.) injection of 4mg/kg morphine exhibited CPP, whereas rats treated with only 0.2mg/kg morphine failed to produce CPP. Intra-CA1 injection of the neuronal NO synthase (nNOS) inhibitor 7-NI, the sGC inhibitor ODQ or the PKG inhibitor Rp-8-Br-PET-cGMPS had no effect on the acquisition of CPP by 4mg/kg morphine. Intra-CA1 injection of 7-NI blocked the consolidation of CPP induced by 4mg/kg morphine, and this amnesic effect of 7-NI was mimicked by ODQ and Rp-8-Br-PET-cGMPS. Intra-CA1 injection of the NOS substrate L-arg or the sGC activator YC-1 with an ineffective dose of morphine (0.2mg/kg, i.p.) elicited CPP. This response induced by L-arg or YC-1 was reversed by pre-microinjection of Rp-8-Br-PET-cGMPS in the CA1. These results indicated that the activation of the NO/sGC/PKG signaling pathway in the CA1 is necessary for the consolidation of morphine-related reward memory.     

背景性质对7-10岁自闭症谱系障碍儿童面孔搜索与加工的作用

为了考察背景性质对ASD者搜索面孔的影响,设计两个眼动实验任务,要求14名7~10岁ASD儿童和20名同年龄正常儿童观看图片。实验一采用将面孔嵌入风景图片中引起语义不一致的刺激;实验二采用含有面孔的无意义背景乱序图片刺激。结果发现：（1）面孔与背景语义不一致并不能促进ASD儿童对面孔的搜索;（2）乱序背景对ASD儿童面孔搜索与加工没有产生干扰作用,但使正常儿童的搜索时间变长;（3）一旦觉察到面孔后,ASD儿童对面孔的注视时间少于正常儿童。表明正常儿童对面孔的搜索与加工受背景性质的影响,而ASD儿童不受背景性质的影响;一旦发现面孔,ASD儿童的注意维持较短,但面孔加工模式与正常儿童相似。     

Shear band evolution during large plastic deformation of brittle and ductile metallic glasses

Four monolithic metallic glasses (MMGs) with different plasticities varying from brittle to ductile behavior under unconstrained loading were subjected to small punch testing. All specimens undergo large plastic deformation with multiple cobweb-like shear bands under these conditions. The process of shear band evolution was carefully controlled and investigated. Plasticity of MMGs is characterized by equivalent plastic strain ε* (product of shear band density and critical shear offset). Thus, this article provides an experimental basis for a better understanding of the shear band evolution during plastic deformation of MMGs.     

A Model of Chinese Adolescents' Creative Personality

Since the 1950s, there has been a systemic development of research on creative personality. Three themes are apparent in this literature: individual differences of creative people, the construct of creative personality, and longitudinal studies about creative personality. However, little research has been conducted in any of these areas with Chinese samples, and the purpose of this study is to study the construct of Chinese adolescents' creative personality. Confirmatory factor analyses were conducted with data from 1,300 Chinese adolescents. The results provide evidence that adolescents' creative personality consists of three largely independent dimensions: Internal, External, and Self. The internal factor includes self-confidence, norm-doubt, internal motivation, and persistence; the external factor includes curiosity, risk-taking, openness and independence; the self factor pertains to self-acceptance.     

Right Hemispheric Dominance of Creative Insight: An Event-Related Potential Study

The purpose of this study was to investigate the hemispheric effect of creative insight. This study used high-density ERPs to record participants' brain activity while they performed an insight task. Results showed that both insight solutions and incomprehension solutions elicited a more negative ERP deflection (N320～550) than noninsight solutions in the time window of 320～550 msec. Scalp ERPs and topographical maps revealed that the insight N320～550 exhibited a relative RH dominance, whereas the incomprehension N320～550 exhibited a relative midline dominance. Dipole source analysis showed that the generator of N320～550 elicited by insight and incomprehension solutions was localized in the right middle frontal gyrus and the right parahippocampus gyrus, respectively. These distinct spatiotemporal patterns involved in insight processing and incomprehension processing suggest that the observed N320～550 might reflect the processing of set-shift and the formation of novel associations. Moreover, the spatiotemporal pattern of brain activation associated with insight solutions supported the idea that the right hemispheric dominance theory of creative thinking also applies to creative insight.     

Quantile Mediation Models: A Comparison of Methods for Assessing Mediation Across the Outcome Distribution

Recent introduction of quantile regression methods to analysis of epidemiologic data suggests that traditional mean regression approaches may not suffice for some health outcomes such as Body Mass Index (BMI). In the same vein, the traditional mean-based approach to mediation modeling may not be sufficient to capture the potentially different mediating effects of behavioral interventions across the outcome distribution. By combining methods for estimating conditional quantiles with traditional mediation modeling techniques, mediation effects can be estimated for any quantile of the outcome distribution (so-called quantile mediation effects). Estimation and inference techniques for quantile mediation effects are compared through simulation studies, and recommendations are given. The quantile mediation methods are further compared with the traditional mean-based regression approaches to mediation analysis through analysis of data from Healthy Places, a trial that is examining the effects of the community–built environment on resident obesity risk. We found the magnitudes of indirect (mediating) effects of walkability on BMI and waist circumference were substantially larger for the upper quantiles compared with the median or mean. Results suggest that restricting the examination of mediation to the mean of the outcome distribution provides an incomplete picture of proposed mediating mechanisms and in some cases may miss important mediational relationships to outcomes.     

Gender Differences in Reasons for Entering and Leaving Education Administration: Discriminant Function Analyses

Using discriminant function analyses on survey data collected from 457 students in 29 education administration programs across the United States, the authors inquired into whether men and women decide to enter and possibly leave education administration for different reasons. There were statistically significant functions separating men and women in their reasons for entering and leaving education administration. Implications of the findings are discussed.     

大学生脑科学素养现状调查

采用《大学生脑科学素养问卷》,对天津市1450名大学生脑科学素养现状进行了调查分析。结果显示:(1)大学生总体脑科学问卷正确率显著低于60%,其中,脑的功能、脑的组织结构和脑与学方面的得分更低;(2)书籍、网络和电视是大学生获取脑科学知识的重要渠道;(3)大学生对脑科学知识的总体关心程度偏低;(4)大学生脑科学素养水平受成长环境和父母文化程度因素的影响,存在年级和性别差异。     

父母教养方式对初中生攻击行为的影响:越轨同伴交往和自我控制的作用

以631名初中生为被试,采用问卷法考察父母教养方式与初中生攻击行为的关系,同时探讨越轨同伴交往的中介作用,以及该作用是否受自我控制的调节。结果发现：（1）消极父母教养方式对越轨同伴交往、攻击行为均有显著的正向预测作用;（2）越轨同伴交往在消极父母教养方式与初中生攻击行为之间起部分中介作用;（3）自我控制可以调节越轨同伴交往对初中生攻击行为的作用,对于低自我控制个体,越轨同伴交往起部分中介作用;对于高自我控制个体,越轨同伴交往的中介效应不显著,消极父母教养方式对攻击行为仅有直接作用。     

儒家文化中的共情观

共情是个体设身处地地共享并理解他人的情绪情感的心理现象,是道德与利他行为的动机源泉。儒家文化作为中国传统文化的主体,蕴含着具有深远理论意义和生动实践意义的共情观。本文将共情的情绪与认知两种成分作为视角,对儒家经典文本中的共情观进行梳理、分析与比较,发现儒家文化中的"恻隐之心"、"一体之仁"、"忠恕之道"、"絜矩之道"等思想观点在作为人们日常生活中接物待人道德伦理观的同时,在社会交往、理解他人等方面与共情具有相同的心理机制以及心理学原理。基于此发现,未来在继续探究儒家核心观念"仁"等文本与共情的联系与区别的同时,还可以针对儒式文化中的共情观,进一步尝试实证性研究。