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601.
The beta-amyloid precursor protein (APP) plays a central role in Alzheimer's disease (AD) and appears to be a multifunctional protein. Secreted forms of APP (sAPP) have memory-enhancing effects in certain behavioral paradigms. To investigate sAPP's role in spatial memory processes, we adapted a spatial recognition task and evaluated (1) the performance of OF1 mice after massed training (single 15-min acquisition session) and distributed training (three 5-min acquisition sessions), (2) the decline of spatial recognition performance by introducing different delays (5min, 1, 3, and 24h) between the acquisition and retention phases, and (3) the effects of sAPP(695) on spatial recognition memory. In the present study, mice selectively reacted to a change in the spatial configuration of five objects. Indeed, 3min post-acquisition, mice performed similarly in the massed and distributed versions of the task, by re-exploring the two displaced objects only, whereas mice exposed to the same spatial configuration did not. Additionally, all mice did react to a novel object in a subsequent object recognition phase. Mice detected object displacements 5min, 1h, or 3h post-acquisition, but no more at a 24h-delay. Finally, mice treated with sAPP(695) intracerebroventricularly at a dose of 0.5pg/4microL/mouse, 20-min pre-acquisition or 5-min post-acquisition, still reacted to a spatial change in objects position 24h post-acquisition, in marked contrast to NaCl-treated mice. Our data demonstrate that sAPP(695) significantly improves a form of spatial memory, and confirms the hypothesis of an action of this protein on early memory processes. 相似文献
602.
Crowell SE Beauchaine TP Gatzke-Kopp L Sylvers P Mead H Chipman-Chacon J 《Journal of abnormal psychology》2006,115(1):174-178
Numerous studies have revealed autonomic underarousal in conduct-disordered adolescents and antisocial adults. It is unknown, however, whether similar autonomic markers are present in at-risk preschoolers. In this study, the authors compared autonomic profiles of 4- to 6-year-old children with attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD; n = 18) with those of age-matched controls (n = 20). Children with ADHD and ODD exhibited fewer electrodermal responses and lengthened cardiac preejection periods at baseline and during reward. Although group differences were not found in baseline respiratory sinus arrhythmia, heart rate changes among ADHD and ODD participants were mediated exclusively by parasympathetic withdrawal, with no independent sympathetic contribution. Heart rate changes among controls were mediated by both autonomic branches. These results suggest that at-risk preschoolers are autonomically similar to older externalizing children. 相似文献
603.
Two experiments investigated sensory/motor-based functional knowledge of man-made objects: manipulation features associated with the actual usage of objects. In Experiment 1, a series of prime-target pairs was presented auditorily, and participants were asked to make a lexical decision on the target word. Participants made a significantly faster decision about the target word (e.g. ‘typewriter’) following a related prime that shared manipulation features with the target (e.g. ‘piano’) than an unrelated prime (e.g. ‘blanket’). In Experiment 2, participants' eye movements were monitored when they viewed a visual display on a computer screen while listening to a concurrent auditory input. Participants were instructed to simply identify the auditory input and touch the corresponding object on the computer display. Participants fixated an object picture (e.g. “typewriter”) related to a target word (e.g. ‘piano’) significantly more often than an unrelated object picture (e.g. “bucket”) as well as a visually matched control (e.g. “couch”). Results of the two experiments suggest that manipulation knowledge of words is retrieved without conscious effort and that manipulation knowledge constitutes a part of the lexical-semantic representation of objects. 相似文献
604.
Child-Directed Interaction: Prediction of Change in Impaired Mother–Child Functioning 总被引:1,自引:0,他引:1
The first phase of parent–child interaction therapy (PCIT), called child-directed interaction, teaches parents to use positive and differential social attention to improve the parent–child relationship. This study examined predictors of change in mother and child functioning during the child-directed interaction for 100 mother–child dyads. The children were 3–6-years-old and diagnosed with oppositional defiant disorder. After establishing that significant improvements occurred in mother report of child disruptive behavior, parenting stress, and parenting practices, these three variables were combined to form a latent impaired mother–child functioning construct. Structural equation models were examined using maternal demographic and psychosocial variables as predictors of impaired mother–child functioning before and after the child-directed interaction. Mothers’ self-reported daily hassles and depressive symptomatology predicted 74% of variance in impaired mother–child functioning before treatment. Mothers’ report of social support predicted impaired mother–child functioning after the child-directed interaction, with 57% of the variance accounted for in this longitudinal model. These findings suggest the importance of improving maternal social support during the initial phase of PCIT.
相似文献
Sheila M. EybergEmail: |
605.
OBJECTIVE: The purpose of this study was to see whether participants who persist in their stutter have poorer sensitivity in a backward masking task compared to those participants who recover from their stutter. DESIGN: The auditory sensitivity of 30 children who stutter was tested on absolute threshold, simultaneous masking, backward masking with a broadband and with a notched noise masker. The participants had been seen and diagnosed as stuttering at least 1 year before their 12th birthday. The participants were assessed again at age 12 plus to establish whether their stutter had persisted or recovered. Persistence or recovery was based on participant's, parent's and researcher's assessment and Riley's [Riley, G. D. (1994). Stuttering severity instrument for children and adults (3rd ed.). Austin, TX: Pro-Ed.] Stuttering Severity Instrument-3. Based on this assessment, 12 speakers had persisted and 18 had recovered from stuttering. RESULTS: Thresholds differed significantly between persistent and recovered groups for the broadband backward-masked stimulus (thresholds being higher for the persistent group). CONCLUSIONS: Backward masking performance at teenage is one factor that distinguishes speakers who persist in their stutter from those who recover. Education objectives: Readers of this article should: (1) explain why auditory factors have been implicated in stuttering; (2) summarise the work that has examined whether peripheral, and/or central, hearing are problems in stuttering; (3) explain how the hearing ability of persistent and recovered stutterers may differ; (4) discuss how hearing disorders have been implicated in other language disorders. 相似文献
606.
In a series of experiments, the effect of white noise distortion and talker variation on lexical access in normal and Broca's aphasic participants was examined using an auditory lexical decision paradigm. Masking the prime stimulus in white noise resulted in reduced semantic priming for both groups, indicating that lexical access is degraded by nonlinguistic white noise distortion. However, talker variation within a prime-target pair had no effect upon the performance of either the normal or aphasic individuals. The absence of a talker variation effect suggests that voice-specific information is not encoded in the lexical representations of words. The normal performance of Broca's aphasics under conditions of both white noise and talker variation supports the view that these patients have a lexical processing impairment rather than a more generalized language deficit characterized by limited computational resources. 相似文献
607.
In the complexity of the entangled interactions within the group of psychoanalytical pionneers, their divergent interests and views, the Ferenczi-Jung relationship is of particular interest given the importance that both had in the field of the history of ideas. It is striking to discover some parallel lines, but interpersonal, institutional and socio-cultural factors contributed to the fact that this peaceful and complementary collaboration was not possible in the long run. Perhaps for the present generation, in retrospective, it is easier to notice seminal strokes and also some deficiencies in all these thinkers. 相似文献
608.
Although it is estimated that domestic abuse is as common in gay male and lesbian intimate relationships as in heterosexual relationships, the legal system often fails to recognize or respond to same-gender cases. Empirical research examining the impact of sexual orientation on perceptions of abuse is virtually nonexistent. Undergraduates (N = 252) read a summary of a domestic abuse incident in which victims and perpetrators varied by gender and, by implication, sexual orientation. Victim and respondent gender, rather than the couple's sexual orientation, primarily affected responses to domestic abuse. Domestic abuse perpetrated against women was perceived to be more serious and in need of intervention than abuse against men. Women were more likely than men to believe the victim and to recommend criminal justice system interventions. Because they are inconsistent with gender role stereotypes, domestic abuse cases involving male victims or female perpetrators may not receive equitable treatment within the criminal justice system. 相似文献
609.
Peters JA Hoskins L Prindiville S Kenen R Greene MH 《Journal of genetic counseling》2006,15(6):477-489
The CEGRM was initially conceived as a simple, concise, visual representation of the social interaction domains of information, tangible services and emotional exchanges (Kenen, R., & Peters, J. (2001). J Genet Counsel, 10, 289–309). A blend of the genetic pedigree, genogram, and ecomap, the CEGRM was developed to facilitate contemporary genetic counseling goals. An exploratory pilot study of 20 subjects showed that it was feasible, comfortable and efficiently accomplished, and that the process was useful both for assessment and as an intervention with study participants (Peters, J. A., Kenen, R., Giusti, R., Loud, J., Weissman, N., & Greene, M. H. (2004). Am J Med Genet Part A, 130A, 258–264). Subsequently, we have extended the CEGRM to 150 women from hereditary breast/ovarian cancer (HBOC) families; three different investigators have successfully administered this tool. The preliminary findings from the exploratory study were confirmed in the larger sample. Engaging in the interactive, insight-promoting CEGRM process provides a novel tool for assessing the social context of genetic testing, and helping high-risk women better understand and integrate genetic information into their personal and family identities, health beliefs, and decisions. 相似文献
610.
Gosselin J Gahagan S Amiel-Tison C 《Mental retardation and developmental disabilities research reviews》2005,11(1):34-51
The Amiel-Tison Neurological Assessment at Term (ATNAT) is part of a set of three different instruments based on a neuro-maturative framework. By sharing a same methodology and a similar scoring system, the use of these three assessments prevents any rupture in the course of high risk children follow-up from 32 weeks post-conception to 6 years of age. The ATNAT which takes 5 minutes to administer may be used in clinical setting as well as in research. Clustering of severe to mild neuro-cranial signs in the neonatal period permits identification of children who could benefit from early intervention. 相似文献