Functional neuroimaging of working memory in survivors of childhood brain tumors and healthy children: Associations with coping and psychosocial outcomes

Purpose: Pediatric brain tumors are the second most common cancer diagnosis in individuals under age 20 and research has documented significant neurocognitive, psychosocial, and emotional late effects. Associations among these deficits have not been adequately considered and the role of survivors’ coping with stress in relation to deficits is unknown. Further, research has yet to examine neurobiological processes related to neurocognitive, psychosocial, and emotional difficulties in survivors through the use of functional neuroimaging. Method: Questionnaire measures and functional neuroimaging were used to examine the neurocognitive, psychosocial, and emotional functioning and coping responses of survivors of pediatric brain tumors (N = 17; age 8–16) and healthy children (N = 15). Results: Survivors experienced elevated levels of psychosocial and behavioral/emotional difficulties relative to healthy controls and normative data. Increases in brain activation in prefrontal and other anterior regions in response to a working memory task were associated with better psychosocial functioning, use of engagement coping strategies, and less use of disengagement coping strategies. Regression analyses suggest coping accounts for a significant portion of the association between brain activation and behavioral/emotional functioning. Conclusions: This study extends late-effects research by examining neurobiological processes associated with psychosocial and emotional difficulties. These findings contribute to our understanding of difficulties in survivors and provide a foundation for research exploring these associations and mediators of deficits in future longitudinal studies.     

Two-Year-Olds' Object Retrieval Based on Television: Testing a Perceptual Account

Two-year-olds frequently fail to use information provided by video to find objects hidden in an adjacent room. Schmitt and Anderson (2002) hypothesized that they fail to map the 2-dimensional (2D) video image onto the 3D layout of the search space. Two experiments tested whether 2-year-olds can successfully use information from video when the search space is 2D or when the information is provided verbally (by telling the child where the toy is hidden). In both experiments, children performed poorly in the video conditions but performed well in direct live experience comparison conditions, contradicting Schmitt and Anderson's hypothesis. Performance was above chance on the first trial in the video conditions, suggesting that 2-year-olds do have a memory of the hiding location, albeit one that is easily disrupted by perseverative errors on subsequent trials. Overall, the results are most consistent with the hypothesis that very young children give priority to direct experience over mediated information.     

Updating misconceptions: Effects of age and confidence

Young adults are more likely to correct an initial higher confidence error than a lower confidence error (Butterfield & Metcalfe, 2001). This hypercorrection effect has never been investigated among older adults, although features of the standard paradigm (free recall, metacognitive judgments) and prior evidence of age-related error resolution deficits (see Clare & Jones, 2008) suggest that they may not show this effect. In Study 1, we used free recall and a 7-point confidence scale; in Study 2, we used multiple-choice questions, and participants indicated how many alternatives they had narrowed their options down to prior to answering. In both studies, younger and older adults showed a hypercorrection effect, and this effect was equivalent between groups in Study 2 when free recall and explicit confidence ratings were not required. These results are consistent with our previous work (Cyr & Anderson, 2012) showing that older adults can successfully resolve learning errors when the learning context provides sufficient support.     

Prolonged Exposure Therapy for a Vietnam Veteran With PTSD and Early-Stage Dementia

Although prolonged exposure therapy (PE) is considered an evidence-based treatment for PTSD, there has been little published about the use of this treatment for older adults with comorbid early-stage dementia. As the number of older adults in the United States continues to grow, so will their unique mental health needs. The present article describes the successful coordination of care and application of PE in the assessment and treatment of a Vietnam veteran with comorbid PTSD and early-stage dementia. Measures related to the patient's cognitive and psychological functioning were obtained before, during, and after treatment. PE was associated with significant declines in PTSD and depression symptoms. Moreover, the patient's cognitive functioning was made clearer in the absence of severe psychiatric symptoms. Factors contributing to the patient's positive response are discussed.     

Pictorial rehearsal effects in younger and older adults

Abstract

In three studies, we examined pictorial rehearsal effects in younger and older adults. Concrete and abstract line drawings that varied in the amount of pictorial detail were presented for study under different presentation conditions. In the pictorial rehearsal condition, each picture was followed by a blank rehearsal interval where the picture was no longer presented. In all three experiments, the poststimulus interval enhanced picture recognition for both age groups, relative to a control condition where no rehearsal interval occurred. These findings suggest that older adults, like younger adults, form and maintain visual images across a blank rehearsal interval. Implications of these findings for current views on imaginal processes in older adults are discussed.     

Inhibitory processes and the control of memory retrieval

People are often confronted with reminders of things they would prefer not to think about. When this happens, they often attempt to put the unwanted memories out of awareness. Recent research shows that the capacity to suppress distracting traces is mediated by executive-control processes that are analogous to those involved in overriding prepotent motor responses, and it is these processes that cause persisting memory failures for the suppressed items. There is evidence that memory retrieval and motor tasks that are likely to demand executive control recruit overlapping neural mechanisms, suggesting that a common process mediates control in these domains. Together, these findings indicate that memory failures often arise from the mechanisms that lie at the heart of our capacity to influence the focus of thought.     

Review of Jesus

This new psychobiographical analysis of Jesus by Donald Capps promises to be a controversial but important book. While the venture is an engaging one, new theses about what and why Jesus did what he did suffer the same sorts of challenges as have traditional and critical presentations of the historical Jesus. This review engages theological issues and their implications, historical judgments and their plausibility, and methodological approaches and their fruitfulness.     

One Family at a Time: A Prevention Program for At‐Risk Parents

The purpose of this study was to examine the effectiveness of a psychoeducational parenting program with at‐risk parents of young children. At‐risk was defined as excessive parental use of verbal and corporal punishment combined with low‐income status. All families were seen for 10 weeks, either individually or in very small groups. Results showed that compared with the control group, parents participating in the program significantly decreased their levels of verbal and corporal punishment, anger, stress, and reported child behavior problems; results were maintained at follow‐up. Implications for counselors are provided.