Does Therapeutic Repetitive Transcranial Magnetic Stimulation Cause Cognitive Enhancing Effects in Patients with Neuropsychiatric Conditions? A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a therapeutic intervention for neuropsychiatric illnesses and has demonstrated efficacy for treatment of major depression. However, an unresolved question is whether a course of rTMS treatment results in effects on cognitive functioning. In this systematic review and meta-analysis we aimed to quantitatively determine whether a course of rTMS has cognitive enhancing effects. We examined cognitive outcomes from randomised, sham-controlled studies conducted in patients with neuropsychiatric conditions where rTMS was administered to the dorsolateral prefrontal cortex (DLPFC) across repeated sessions, searched from PubMed/MEDLINE and other databases up until October 2015. Thirty studies met our inclusion criteria. Cognitive outcomes were pooled and examined across the following domains: Global cognitive function, executive function, attention, working memory, processing speed, visual memory, verbal memory and visuospatial ability. Active rTMS treatment was unassociated with generalised gains across the majority of domains of cognitive functioning examined. Secondary analyses revealed a moderate sized positive effect for improved working memory in a small number of studies in patients with schizophrenia (k = 3, g = 0.507, 95 % CI = [0.183–0.831], p < .01). Therapeutic rTMS when administered to the DLPFC in patients with neuropsychiatric conditions does not result in robust cognitive enhancing effects.     

Evolutionary Relevance and Experience Contribute to Face Discrimination in Infant Macaques (Macaca mulatta)

In human children and adults, familiar face types—typically own-age and own-species faces—are discriminated better than other face types; however, human infants do not appear to exhibit an own-age bias but instead better discriminate adult faces, which they see more often. There are two possible explanations for this pattern: Perceptual attunement predicts advantages in discrimination for the most experienced face types. Additionally or alternatively, there may be an experience-independent bias for infants to discriminate own-species faces, an adaptation for evolutionarily relevant faces. These possibilities have not been disentangled in studies thus far, and these studies did not control infants’ early experiences with faces. In the present study, we tested these predictions in infant macaques (Macaca mulatta) reared under controlled environments, not exposed to adult conspecifics. We measured newborns’ (15–25 days; n = 27) and 6- to 7-month-olds’ (n = 35) discrimination of human and macaque faces at 3 ages—young infants, old infants, and adults—in a visual paired comparison task. We found that 6- to 7-month-olds were the best at discriminating adult macaque faces; however, in the first few seconds of looking, tthey additionally discriminated familiar face types—same-aged peer and adult human faces—thereby highlighting the importance of experience with certain face categories. The present data suggest that macaque infants possess both experience-independent and experientially tuned face biases. In human infants, early face skills may likewise be driven by both experience and evolutionary relevance; future studies should consider both of these factors.     

Trustworthiness and Moral Character

Why are people trustworthy? I argue for two theses. First, we cannot explain many socially important forms of trustworthiness solely in terms of the instrumentally rational seeking of one’s interests, in response to external sanctions or rewards. A richer psychology is required. So, second, possession of moral character is a plausible explanation of some socially important instances when people are trustworthy. I defend this conclusion against the influential account of trust as ‘encapsulated interest’, given by Russell Hardin, on which most trustworthiness is explained by the interest of continuing relationship.     

Force versus fury: Sex differences in the relationships among physical and psychological threat potential,the facial width‐to‐height ratio,and judgements of aggressiveness

Individuals with larger facial width‐to‐height ratios (FWHRs) are judged as more threatening, and engage in more threat‐related behavior, than do individuals with smaller FWHRs. Here we identified components of threat potential that are related to the FWHR. In Study 1, the FWHR was correlated positively with physical threat potential (bicep size) in women and with both physical and psychological (anger proneness) threat potential in men. Behavioral aggression was measured in a subset of these participants using the Point Subtraction Aggression Paradigm (costly aggression) and a Money Allocation Task (non‐costly aggression). Psychological (but not physical) threat potential predicted non‐costly aggression and physical (but not psychological) threat potential predicted costly aggression. In Study 2, a separate set of participants judged the anger proneness, strength, or aggressiveness of male participants photographed in Study 1. Participants’ judgements of all three characteristics were associated with the FWHR, and there were sex differences in how aggressiveness was conceptualized (for women, aggressiveness was associated with anger proneness, for men, aggressiveness was associated with strength). These results are consistent with the hypothesis that the FWHR may be an adaptation to cue the threat potential of men.

     

Face detection in 2‐ to 6‐month‐old infants is influenced by gaze direction and species

Humans detect faces efficiently from a young age. Face detection is critical for infants to identify and learn from relevant social stimuli in their environments. Faces with eye contact are an especially salient stimulus, and attention to the eyes in infancy is linked to the emergence of later sociality. Despite the importance of both of these early social skills—attending to faces and attending to the eyes—surprisingly little is known about how they interact. We used eye tracking to explore whether eye contact influences infants' face detection. Longitudinally, we examined 2‐, 4‐, and 6‐month‐olds' (N = 65) visual scanning of complex image arrays with human and animal faces varying in eye contact and head orientation. Across all ages, infants displayed superior detection of faces with eye contact; however, this effect varied as a function of species and head orientation. Infants were more attentive to human than animal faces and were more sensitive to eye and head orientation for human faces compared to animal faces. Unexpectedly, human faces with both averted heads and eyes received the most attention. This pattern may reflect the early emergence of gaze following—the ability to look where another individual looks—which begins to develop around this age. Infants may be especially interested in averted gaze faces, providing early scaffolding for joint attention. This study represents the first investigation to document infants' attention patterns to faces systematically varying in their attentional states. Together, these findings suggest that infants develop early, specialized functional conspecific face detection.     

Different relational models underlie prototypical left and right positions on social issues

Social issues are important dividing lines in the “culture wars” between the political left and right. Despite much research into social issue stance and ideology, little research has explored these with Relational Models Theory (RMT). RMT proposes four distinct models that people use to construe social relations, each entailing distinct moral considerations. In two studies, participants read summaries of the models, rated how relevant each was to their positions on several social issues (e.g., capital punishment), and expressed issue positions. In Study 1, Communal Sharing and Equality Matching construals predicted prototypical liberal positions across a range of issues; Authority Ranking and Market Pricing construals predicted prototypical conservative positions. By using multilevel modelling in Study 2, individual differences in average Communal Sharing and Authority Ranking construals predicted prototypical liberal and conservative positions, respectively, independent of several factors known to predict social issue stance. In issue‐specific analyses (e.g., focusing on euthanasia), all models showed effects independent of self‐reported ideology, while for certain issues (same‐sex marriage, animal testing, gun control, and flag burning), issue construal using different models predicted opposing positions, implicating relational models in moral disagreement. This paper provides novel tests of Relationship Regulation Theory and suggests that RMT is relevant in understanding political ideology, social issue stance, and moral judgement. Copyright © 2014 John Wiley & Sons, Ltd.     

Translations Between Gentzen–Prawitz and Jaśkowski–Fitch Natural Deduction Proofs

Two common forms of natural deduction proof systems are found in the Gentzen–Prawitz and Ja?kowski–Fitch systems. In this paper, I provide translations between proofs in these systems, pointing out the ways in which the translations highlight the structural rules implicit in the systems. These translations work for classical, intuitionistic, and minimal logic. I then provide translations for classical S4 proofs.

     

Voluntary Remembering: Elucidating the Mental Strategies Used to Recall the Past

This study investigated the possibility that people use multiple different types of voluntary retrieval strategies when they are attempting to recall past episodes. In two experiments, we used a retrieve out loud procedure where participants were required to verbalize their thoughts while attempting to retrieve personal memories in response to phrase cues. In Experiment 1, we hypothesized that three main types of voluntary retrieval strategies would be evident during the retrieve out loud procedure, repeating, temporal, and generative/hierarchical retrieval. The results confirmed our hypothesis, showing that the three strategies were used equally. In Experiment 2, we examined the retrieval speed and success rates of the three strategies. The results showed that the repeating strategy was statistically faster than the other two strategies, while also showing that the temporal strategy had the least success in generating memories.Copyright © 2017 John Wiley & Sons, Ltd.