Accidental germ-line modifications through somatic cell gene therapies: some ethical considerations

Proposed somatic cell gene-therapies (especially those involving in utero therapies) may involve a small risk of germ-line modifications; this risk has engendered serious concern, and arguments have been made that such therapies ought not be pursued if such risks exists. We argue here that while pursuing deliberate germ-line modifications in humans would be inappropriate given the current state of the art, the risk of accidental germ-line modifications from most currently proposed in utero gene therapy is no different in kind or degree from other risks regularly taken in medical procedures. Given the possible benefits of such therapies, we argue that the risk of accidental germ-line modifications is well worth taking in these cases.     

Vitamins, minerals, and mood

In this article, the authors explore the breadth and depth of published research linking dietary vitamins and minerals (micronutrients) to mood. Since the 1920s, there have been many studies on individual vitamins (especially B vitamins and Vitamins C, D, and E), minerals (calcium, chromium, iron, magnesium, zinc, and selenium), and vitamin-like compounds (choline). Recent investigations with multi-ingredient formulas are especially promising. However, without a reasonable conceptual framework for understanding mechanisms by which micronutrients might influence mood, the published literature is too readily dismissed. Consequently, 4 explanatory models are presented, suggesting that mood symptoms may be expressions of inborn errors of metabolism, manifestations of deficient methylation reactions, alterations of gene expression by nutrient deficiency, and/or long-latency deficiency diseases. These models provide possible explanations for why micronutrient supplementation could ameliorate some mental symptoms.     

Heart rate variability as a physiological moderator of the relationship between race-related stress and psychological distress in African Americans

This study examined the moderator effects of heart rate variability, a physiological marker of stress vulnerability, on the relationship between race-related stress and psychological distress in African Americans (N = 215). Participants were administered the Index of Race-Related Stress-Brief and the Brief Symptom Inventory-18. Resting heart rate was recorded using the Polar 810s heart rate monitor. Findings indicated that heart rate variability moderated the relationship between institutional race-related stress and psychological distress for men, but not women. These findings suggest that higher levels of resting heart rate variability may buffer African Americans from the deleterious effects of race-related stress.