Accidental germ-line modifications through somatic cell gene therapies: some ethical considerations

Proposed somatic cell gene-therapies (especially those involving in utero therapies) may involve a small risk of germ-line modifications; this risk has engendered serious concern, and arguments have been made that such therapies ought not be pursued if such risks exists. We argue here that while pursuing deliberate germ-line modifications in humans would be inappropriate given the current state of the art, the risk of accidental germ-line modifications from most currently proposed in utero gene therapy is no different in kind or degree from other risks regularly taken in medical procedures. Given the possible benefits of such therapies, we argue that the risk of accidental germ-line modifications is well worth taking in these cases.     

Individual Breaches of Environmental Laws in Cases from Public Administration Files

The characteristics of environmental transgressions and transgressors involved in 1,505 files handled by 4 public administrations were assessed. These administrations were in charge of environmental law enforcement in a highly protected setting, across federal, state, island, and municipality jurisdictions. Special attention was given to the transgressors' written responses to administrative sanctions included in the files. These were analyzed integrating the approaches of neutralization techniques and of accounts as strategies of conflict management. Results suggest that most environmental transgressions under study were carried out by private individuals in the personal domain of everyday life, and that transgressors' accounts of environmental transgressions were short, straightforward, and questioned the legitimacy of the environmental law being broken.     

Individuation and Attachment in Israel and Thailand: Secular Versus Religious Jews and Buddhists

Two of the most important constructs in social, developmental, and clinical psychology are attachment and individuation. This study examined the impact of degree and type of religion on them by comparing the results of religious-national type (Israeli Jewish vs. Thai Buddhist) and degree of religiosity (religious vs. secular) on four subscales of the Individuation-Attachment Questionnaire: Need for Individuation, Fear of Individuation, Need for Attachment, and Fear of Attachment. Four groups of participants were compared: 61 religious Israeli Jews, 71 secular Israeli Jews, 17 religious Thai Buddhists, and 20 secular Thai Buddhists. Significant differences were found on all subscales, with religious Thai Buddhists lowest on all four of them. The secular Thais were highest in Fear of Individuation and Attachment and Need for Individuation. The religious Israeli Jews were highest in Need for Attachment. Because these concepts are sometimes difficult to distinguish, correlations were calculated to determine whether and which concepts were confabulated by each group, shedding further light on their views of interpersonal distance. These results were analyzed through examination of the differing worldviews and observances of Judaism and Buddhism with regard to individuation and attachment. Striking differences were found in the comparative narratives, leading to differential schemata for individuation and attachment, for both religious and secular subsamples within each religious-national community. These religious-national milieus were found to influence attitudes and behaviors toward one's ideal concept of interpersonal distance, specifically with regard to the constructs of individuation and attachment. Attachment is highly valued in Judaism, whereas detached compassion is the goal of Buddhistic teaching.     

Family Communication of BRCA1/2 Results and Family Uptake of BRCA1/2 Testing in a Diverse Population of BRCA1/2 Carriers

Previous studies examining communication of BRCA1/2 results with relatives and family uptake of BRCA1/2 testing have sampled from predominantly white, high SES cohorts ascertained solely from tertiary care centers. No studies have focused on family communication and testing among relatives of diverse BRCA1/2 carriers. We conducted structured interviews with 73 BRCA1/2 carriers identified at a public hospital and a tertiary cancer center. We asked participants if each first- and second-degree relative was aware of their BRCA1/2 results and whether or not each relative had tested. Generalized estimating equations identified rates and predictors of family communication and testing. Participants disclosed their test results to 73 % of 606 eligible relatives and 31 % of 514 eligible relatives tested. Communication and testing rates were similar for relatives of participants from the public hospital and the tertiary cancer center. Hospital site was not a significant predictor of either result disclosure or relative uptake of testing. African American and Asian/Pacific Islander participants were significantly less likely to disclose their results to their relatives; relatives of African American participants were significantly less likely to test. Addressing these disparities will require further research into the best ways to facilitate family communication and counsel at-risk relatives of racially and socioeconomically diverse BRCA1/2 mutation carriers.     

Bayesian Model Averaging for Propensity Score Analysis

This article considers Bayesian model averaging as a means of addressing uncertainty in the selection of variables in the propensity score equation. We investigate an approximate Bayesian model averaging approach based on the model-averaged propensity score estimates produced by the R package BMA but that ignores uncertainty in the propensity score. We also provide a fully Bayesian model averaging approach via Markov chain Monte Carlo sampling (MCMC) to account for uncertainty in both parameters and models. A detailed study of our approach examines the differences in the causal estimate when incorporating noninformative versus informative priors in the model averaging stage. We examine these approaches under common methods of propensity score implementation. In addition, we evaluate the impact of changing the size of Occam’s window used to narrow down the range of possible models. We also assess the predictive performance of both Bayesian model averaging propensity score approaches and compare it with the case without Bayesian model averaging. Overall, results show that both Bayesian model averaging propensity score approaches recover the treatment effect estimates well and generally provide larger uncertainty estimates, as expected. Both Bayesian model averaging approaches offer slightly better prediction of the propensity score compared with the Bayesian approach with a single propensity score equation. Covariate balance checks for the case study show that both Bayesian model averaging approaches offer good balance. The fully Bayesian model averaging approach also provides posterior probability intervals of the balance indices.     

Estimating Gait Stability: Asymmetrical Loading Effects Measured Using Margin of Stability and Local Dynamic Stability

Changes to intersegmental locomotor control patterns may affect body stability. Our study aimed to (a) characterize upper body dynamic stability in response to the unilateral addition of mass to the lower extremity and (b) evaluate the efficacy of 2 different stability measures commonly used in the literature to detect resulting symmetrical step pattern modifications across the weighted segments (spatial) and between epochs of the gait cycle (temporal). Young adults walked on a treadmill while unloaded or with weights applied unilaterally to their foot, shank, or thigh. Both margin of stability and local dynamic stability (LDS) estimates detected similar trends of distal segment weighting resulting in more unstable upper body movement compared to proximal weighting; however only LDS detected anteroposterior changes in upper body stability over time.     

The Impact of the Testing Environment on Affective Changes Following Acute Resistance Exercise

Research has demonstrated the anxiolytic and affective changes following resistance exercise. However, several studies have allowed the participants to leave the testing facility and return at a later time to complete psychological assessments. This weakens internal validity, making it impossible to interpret findings as due to exercise per se. To address this issue, 23 male participants were randomly assigned to either a “stay” or “go” group. Within each group, all participants completed a non-exercise control session and a weight-training session based on 50% of their one repetition maximum for each of five exercises. All participants remained in the laboratory for 60 minutes following each session, at which time only those in the “go” group left the laboratory and returned at 90 and 120 minutes for their remaining affective assessments. The results indicate that despite transient disruptions in mood, an acute bout of resistance exercise results in positive psychological changes that occur within 60 minutes after completion of the exercise session and which persist up to 120 minutes post-exercise. Allowing participants to leave the laboratory or requiring them to remain in the testing environment was found to lead to different patterns of affective responses during the post-exercise assessment period. Future researchers must take into account such methodological issues when designing acute exercise studies requiring extended periods of post-exercise assessment.     

Spontaneous Self‐Practice of Cognitive Behavioural Therapy (CBT) by Aboriginal Counsellors During and Following CBT Training: A Retrospective Analysis of Facilitating Conditions and Impact

Previous cognitive behavioural therapy (CBT) training studies have suggested that therapists who practice CBT strategies on themselves during training may experience professional and personal benefits. However, it has also been reported that some CBT trainees are reluctant to engage in self‐practice. The present study reports an incidental finding from a CBT training study with Aboriginal counsellors: all five counsellors reported that they practiced CBT techniques on themselves without specific encouragement by the trainers to do so. This paper therefore posed three questions: (a) Why—in contrast to some other trainees—did this group choose to apply CBT to themselves? (b) How did they apply it—with what purpose, in what contexts, and which skills? (c) What was the impact of CBT self‐practice? Data from the group's reflections were qualitatively analysed by two of the researchers, and “member checked” by the remainder. Results indicated that the counsellors were motivated to practice CBT on themselves for two principal reasons: the value they placed on CBT, and their personal need resulting from the high number of crises experienced while living and working in their communities. The counsellors reported practicing CBT in a wide variety of contexts as part of their learning. As in previous studies, the impact of CBT self‐practice was that it increased their confidence and competence as therapists. It also appeared to be a valuable burnout prevention strategy. If the results are generalisable, they suggest that self‐experiential training in CBT may be a culturally responsive and adaptive way for Aboriginal counsellors to enhance their learning of CBT skills.