Personal Genomic Testing as Part of the Complete Breast Cancer Risk Assessment: A Case Report

Patient access and utilization of personal genomic testing is becoming increasingly common. We present a case of a patient's personal genomic screening results leading to early detection of infiltrating breast ductal cell carcinoma via MRI scan. This case exemplifies the successful integration of personal genomic testing into the primary care setting, with the guidance and support of genetic counseling services. We discuss the scientific basis of the patient's genome scan results and risk assessment, and how this informed her decision-making and subsequent screening. We also expound upon the role of personal genomic testing as compared to other screening tests in the complete breast cancer risk assessment.     

The social side of abstraction: psychological distance enhances conformity to group norms

Intuition suggests that a distanced or abstract thinker should be immune to social influence, and on its surface, the current literature could seem to support this view. The present research builds on recent theorizing to suggest a different possibility. Drawing on the notion that psychological distance regulates the extent to which evaluations incorporate context-specific or context-independent information, we suggest that psychological distance should actually increase susceptibility to sources of social influence that tend to be consistently encountered across contexts, such as group norms. Consistent with this hypothesis, two studies showed that psychological distance and abstraction increased conformity to group opinion and that this effect persisted in a novel voting-booth paradigm in which participants believed their voting behavior was both anonymous and consequential. We discuss implications of these findings for understanding the social side of abstraction as well as the conditions under which different types of social influence are likely to be most influential.     

Intolerance of uncertainty and novelty facilitated extinction: The impact of reinforcement schedule

Individuals who score high in intolerance of uncertainty (IU) display reduced threat extinction. Recently, it was shown that replacing threat associations with novel associations during extinction learning (i.e., presenting a novel tone 100% of the time) can promote threat extinction retention in individuals with high IU. This novelty facilitated extinction (NFE) effect could be driven by the tone's novelty or reliability. Here, we sought to address this question by adjusting the reliability of the novel tone (i.e., the reinforcement rate) during NFE. We measured skin conductance response during an associative learning task in which participants (n = 92) were assigned to one of three experimental groups: standard extinction, NFE 100% reinforcement, or NFE 50% reinforcement. For standard extinction, compared to NFE 100% and 50% reinforcement groups, we observed a trend for greater recovery of the conditioned response during extinction retention. Individuals with high IU relative to low IU in the standard extinction group demonstrated a larger recovery of the conditioned response during extinction retention. These findings tentatively suggest that NFE effects are driven by the novelty rather than the reliability of the new stimulus. The implications of these findings for translational and clinical research in anxiety disorder pathology are discussed.     

Skilled Observation and Change Blindness: A Comparison of Law Enforcement and Student Samples

Some evidence suggests that expertise and observational skills training can reduce attentional errors, such as change blindness. Laypeople typically assume that law enforcement officers possess acute observational skills, but no research to date has compared law enforcement and lay samples on their susceptibility to change blindness. In the present study, student and law enforcement samples completed a change blindness task and attempted to identify the target(s) from four line‐ups. Law enforcement officers and students were equally susceptible to change blindness regarding the switch in the target's identity, but students were more likely than officers to detect changes in the target's clothing. Students also performed better on the line‐up task, overall, than officers. Additionally, whereas students' confidence was positively correlated with identification accuracy under some circumstances, officers' confidence was either uncorrelated or negatively correlated with accuracy. We discuss the implications of these findings and suggest some factors accounting for law enforcement officers' relatively poor performance on these tasks. Copyright © 2014 John Wiley & Sons, Ltd.     

The Role of Social and Cognitive Processes in the Relationship Between Fear Network and Psychological Distress Among Parents of Children Undergoing Hematopoietic Stem Cell Transplantation

The current study examined whether cognitive and social processing variables mediated the relationship between fear network and depression among parents of children undergoing hematopoietic stem cell transplant (HSCT). Parents whose children were initiating HSCT (N = 179) completed survey measures including fear network, Beck Depression Inventory, cognitive processing variables (positive reappraisal and self-blame) and social processing variables (emotional support and holding back from sharing concerns). Fear network was positively correlated with depression (p < .001). Self-blame and holding back emerged as individual partial mediators in the relationship between fear network and depression. Together they accounted for 34.3 % of the variance in the relationship between fear network and depression. Positive reappraisal and emotional support did not have significant mediating effects. Social and cognitive processes, specifically self-blame and holding back from sharing concerns, play a negative role in parents’ psychological adaptation to fears surrounding a child’s HSCT.     

Is eye gaze direction always determined without intent?

It is widely assumed that processing of gaze direction occurs “automatically,” in the sense that it is reflexive (unfolds in the absence of intention). We assessed this view in a task in which participants saw a schematic face in which the eyes were gazing left or right, along with a second directional target (an arrow in Experiment 1; a directional word in Experiment 2). The eyes and other directional target were sometimes congruent and other times incongruent. On each trial, participants were cued with a tone to respond to either the direction the eyes were gazing, or the direction the noneye target indicated. The time between the onset of the task cue and the onset of the face was manipulated so that on half the trials the face and the cue were presented at the same time. Regardless of the type of target, the congruency effect was the same size at the zero SOA as it was at the 750 SOA, suggesting that eyes were not processed until participants knew what task to perform. These results are consistent with the claim that processing of gaze direction is, at least some of the time, secondary to an intent (i.e., it is not reflexive).     

Domesticated dogs’ (Canis familiaris) use of the solidity principle

Organisms must often make predictions about the trajectories of moving objects. However, often these objects become hidden. To later locate such objects, the organism must maintain a representation of the object in memory and generate an expectation about where it will later appear. We explored adult dogs’ knowledge and use of the solidity principle (that one solid object cannot pass through another solid object) by evaluating search behavior. Subjects watched as a treat rolled down an inclined tube into a box. The box either did or did not contain a solid wall dividing it in half. To find the treat, subjects had to modify their search behavior based on the presence or absence of the wall, which either did or did not block the treat’s trajectory. Dogs correctly searched the near location when the barrier was present and the far location when the barrier was absent. They displayed this behavior from the first trial, as well as performed correctly when trial types were intermingled. These results suggest that dogs direct their searches in accordance with the solidity principle.     

How Adolescents’ Mental Health Predicts Their Physical Health: Unique Contributions of Indicators of Subjective Well-being and Psychopathology

Studies among youth have established a link between mental health and physical health, and highlight the importance of attending to these relationships to provide a more complete picture of functioning. However, most previous investigations have limited their focus to examining the relationship between physical health and either particular aspects of psychopathology or particular aspects of subjective well-being. The current study serves as a first examination that includes both positive (subjective well-being [SWB]) and negative (psychopathology) indicators of mental health in relation to physical health functioning, assessed via self-report measures completed by a sample of 401 early adolescents from the general population. Mental health indicators accounted for 30% of the variance in physical health ratings, and 4 of the 5 mental health indicators were unique predictors of physical health. Positive affect, a component of SWB, explained the most unique variance in physical health, followed by the other components of SWB. Results support the importance of attending to positive indicators of mental health when determining the link with physical health among youth. Implications for a research and practice focus on comprehensive wellness among youth are discussed.     

Dual-task effects of simulated lane navigation and story recall in older adults with and without memory impairment

ABSTRACT

While driving is a complex task, it becomes relatively automatic over time although unfamiliar situations require increased cognitive effort. Much research has examined driving risk in cognitively impaired elders and found little effect. This study assessed whether mildly memory impaired elders made disproportionate errors in driving or story recall, under simultaneous simulated driving and story recall. Forty-six healthy (61% women; mean age = 76.4) and 15 memory impaired (66% women, mean age = 79.4) elders participated. Cognitive status was determined by neuropsychological performance. Results showed that during dual-task conditions, participants stayed in lane more, and recalled stories more poorly, than when they did the tasks separately. Follow-up analysis revealed that verbatim recall, in particular, was reduced while driving for healthy participants. While memory impaired participants performed more poorly than healthy controls on both tasks, cognitive status was not associated with greater dual-task costs when driving and story recall were combined.