Researcher Perspectives on Conflicts of Interest: A Qualitative Analysis of Views from Academia

The increasing interconnectedness of academic research and external industry has left research vulnerable to conflicts of interest. These conflicts have the potential to undermine the integrity of scientific research as well as to threaten public trust in scientific findings. The present effort sought to identify themes in the perspectives of faculty researchers regarding conflicts of interest. Think-aloud interview responses were qualitatively analyzed in an effort to provide insights with regard to appropriate ways to address the threat of conflicts of interest in research. Themes in participant responses included disclosure of conflicts of interest, self-removal from situations where conflict exists, accommodation of conflict, denial of the existence of conflict, and recognition of complexity of situations involving conflicts of interest. Moral disengagement operations are suggested to explain the appearance of each identified theme. In addition, suggestions for best practices regarding addressing conflicts of interest given these themes in faculty perspectives are provided.     

Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory

Growth arrest and DNA damage-inducible β (Gadd45b) has been shown to be involved in DNA demethylation and may be important for cognitive processes. Gadd45b is abnormally expressed in subjects with autism and psychosis, two disorders associated with cognitive deficits. Furthermore, several high-throughput screens have identified Gadd45b as a candidate plasticity-related gene. However, a direct demonstration of a link between Gadd45b and memory has not been established. The current studies first determined whether expression of the Gadd45 family of genes was affected by contextual fear conditioning. Gadd45b, and to a lesser extent Gadd45g, were up-regulated in the hippocampus following contextual fear conditioning, whereas Gadd45a was not. Next, Gadd45b knockout mice were tested for contextual and cued fear conditioning. Gadd45b knockout mice exhibited a significant deficit in long-term contextual fear conditioning; however, they displayed normal levels of short-term contextual fear conditioning. No differences between Gadd45b knockout and wild-type mice were observed in cued fear conditioning. Because cued fear conditioning is hippocampus independent, while contextual fear conditioning is hippocampus dependent, the current studies suggest that Gadd45b may be important for long-term hippocampus-dependent memory storage. Therefore, Gadd45b may be a novel therapeutic target for the cognitive deficits associated with many neurodevelopmental, neurological, and psychiatric disorders.     

Executive function on the Psychology Experiment Building Language tests

The measurement of executive function has a long history in clinical and experimental neuropsychology. The goal of the present report was to determine the profile of behavior across the lifespan on four computerized measures of executive function contained in the recently developed Psychology Experiment Building Language (PEBL) test battery and evaluate whether this pattern is comparable to data previously obtained with the non-PEBL versions of these tests. Participants (N = 1,223; ages, 5–89 years) completed the PEBL Trail Making Test (pTMT), the Wisconsin Card Sort Test (pWCST; Berg, Journal of General Psychology, 39, 15–22, 1948; Grant & Berg, Journal of Experimental Psychology, 38, 404–411, 1948), the Tower of London (pToL), or a time estimation task (Time-Wall). Age-related effects were found over all four tests, especially as age increased from young childhood through adulthood. For several tests and measures (including pToL and pTMT), age-related slowing was found as age increased in adulthood. Together, these findings indicate that the PEBL tests provide valid and versatile new research tools for measuring executive functions.     

The Implications of Adolescents’ Academic Word Knowledge for Achievement and Instruction

The purpose of the current study was to determine relationships between orthographic and morphological awareness of academic words and achievement across content areas. Participants (n = 256), diverse seventh and eighth graders, took three word knowledge measures; two standardized achievement measures were used as outcomes. Orthographic awareness of academic words explained variance in achievement, beyond overall breadth of vocabulary knowledge, with significant changes in R² ranging from 0.02 to 0.08. Morphological awareness of academic words explained variance in achievement, beyond overall breadth of vocabulary knowledge, with significant changes in R² ranging from 0.06 to 0.16.     

Creativity and Ethics: The Relationship of Creative and Ethical Problem-Solving

Students of creativity have long been interested in the relationship between creativity and deviant behaviors such as criminality, mental disease, and unethical behavior. In this study we wished to examine the relationship between creative thinking skills and ethical decision-making among scientists. Accordingly, 258 doctoral students in the health, biological, and social sciences were asked to complete a measure of creative processing skills (e.g., problem definition, conceptual combination, idea generation) and a measure of ethical decision-making examining four domains: data management, study conduct, professional practices, and business practices. It was found that ethical decision-making in all four of these areas was related to creative problem-solving processes with late-cycle processes (e.g., idea generation and solution monitoring) proving particularly important. The implications of these findings for understanding the relationship between creative and deviant thought are discussed.     

Longitudinal Multi-Trait-State-Method Model Using Ordinal Data

Multi-trait multi-method (MTMM) models provide a way to assess convergent and discriminant validity when multiple traits are measured by multiple methods. In recent years, longitudinal extensions of MTMM models have been proposed in the structural equation modeling framework to evaluate whether and how the trait as well as method factors change over time. We propose a novel longitudinal ordinal MTMM model that can be used to effectively distinguish volatile “state” processes from “trait” processes that tend to remain stable and invariant over time. The proposed model, termed a longitudinal multi-trait-state-method (LM-TSM) model, combines 3 key modeling components: (a) a measurement model for ordinal data, (b) a vector autoregressive moving average model at the latent level to examine changes in the state as well as the method factors over time, and (c) a second-order factor-analytic model to capture time-invariant traits as shared variances among the state factors across all measurement occasions. Data from the Affective Dynamics and Individual Differences (ADID; Emotions and Dynamic Systems Laboratory, 2010 Emotions and Dynamic Systems Laboratory. (2010). The Affective Dynamics and Individual Differences (ADID) study: Developing non-stationary and network-based methods for modeling the perception and physiology of emotions. . Unpublished manual, University of North Carolina at Chapel Hill. [Google Scholar]) study was used to illustrate the proposed longitudinal LM-TSM model. Methodological issues associated with fitting the LM-TSM model are discussed.     

ideology and the stagnation of aoda treatment modalities in america

The disease model of alcoholism was adopted by the American Medical Assoication in 1956, and the intervening 47 years have seen the development of increasingly varied and sophisticated types of evidence for the biological sources of addiction to Alcohol and other drugs of abuse (AODA) . However, a synthesis of 12-step treatment with a confrontational and moralistic version of cognitive psychology remains the modal approach to AODA treatment, despite its inability to even engage many addicts. Simultaneously, the growing evidence for therapies that teach self-regulation of biopsychological processes, which treat clients supportively while encouraging their recognition of the problems and building their desire to change, has been largely ignored by practitioners. The epitome of this self-regulation approach, neurofeedback therapy, has been all but ignored despite reports of high success rates. This paper examines the confluence historical economic and ideological factors that maintain this divergence between knowledge and practice from the perspective of Gusfield's notion of moral passage based on deviant labels.