Response Inhibition and ADHD Traits: Correlates and Heritability in a Community Sample

Endophenotypes or intermediate phenotypes are of great interest in neuropsychiatric genetics because of their potential for facilitating gene discovery. We evaluated response inhibition, latency and variability measures derived from the stop task as endophenotypes of ADHD by testing whether they were related to ADHD traits in the general population, heritable and shared genetic risk with ADHD traits. Participants were 16,099 children and adolescents, ages 6 to 18 years who visited a local science center. We measured ADHD traits using the Strengths and Weaknesses of ADHD-symptoms and Normal-Behavior (SWAN) rating scale and performance on the stop signal task (SST)—response inhibition (SSRT), response latency (GoRT), and response variability (GoRTSD). Regression analysis was used to assess the relationship of cognitive measures and ADHD traits while controlling for family, age, sex, ethnicity, socioeconomic status and treatment status. Heritability of ADHD and cognitive traits was estimated using SOLAR in 7,483 siblings from 3,507 families that included multiple siblings. Bivariate relationships between pairs of variables were examined. Individuals with greater ADHD trait scores had worse response inhibition, slower response latency, and greater variability. Younger participants and girls had inferior performance although the gender effects were minimal and evident in youngest participants. Inhibition, latency, variability, total ADHD traits, inattention and hyperactivity-impulsivity scores were significantly heritable. ADHD traits and inhibition, but not latency or variability were coheritable. In the largest study in the general population, we found support for the validity of response inhibition as an endophenotype of ADHD.     

汉语声调远距离规则的内隐学习及其迁移效应

内隐学习研究领域的一个重要问题是内隐学习获得的知识究竟是什么,即内隐学习获得的知识究竟是底层的抽象规则还是表面的特征.研究以汉语声调的远距离水平映射这一远距离规则为材料,通过对表面特征和底层规则之间的分离操作,在控制组块和重复结构等表面特征的条件下,探讨声调远距离规则的习得和迁移,结果发现被试能够内隐地习得和迁移汉语平仄声调的水平映射规则,证实了内隐学习确实能够获得底层的抽象规则,为内隐学习的抽象性问题提供了新的证据.     

Interaction between color and attentional level in children’s conflict control

Cognitive Processing - Perception of color can affect cognition and behavior in humans. Although there has been increasing interest in the effect of red on cognitive performance in adults, little...     

周雯静艺术作品中的医学话语和疾病隐喻

疾病总是被医学话语提纯为普遍的知识理性,如何在疾病的表象背后找寻个别的生命现象成为一个难题。而女性主义艺术家周雯静却以“带病的身体”作为切入口,用艺术的方式言说医学科学中所忽略和掩盖的内容,深剖疾病现象中不可见的部分,思考“非正常”的身体。通过对女性经验的召唤,周雯静在艺术实践过程中使疾病不再被定位为朝向“死”的必然性,而是在疼痛的体验中回应如何更好地“生”的可能性,并在具体的处境中吁请着人们对生命与医学的共同敬重。

     

Understanding the Relationship between Poverty and Children’s Mental Health in Poverty-Stricken Area of China: Social Causation or Social Selection?

This study aimed to explore the relationship between poverty and children’s mental health in the social context of China. Data were consisted of 1314 children, which were collected with a multi-stage cluster random sampling method in Xiushui, a typical poverty city in China. Structural equation modeling was adopted to test the hypothesized model. Results showed that both social causation model and social selection model could explain the relationship between poverty and children’s mental health in Mainland China. The implications of these findings on theory and social work services were also discussed.     

德里达：翻译与解构

德里达认为,自柏拉图以来的西方理性主义有一个根本的错误,即都在寻找某些“超验所指”(在任何语言中的任何时间都表达同样概念的所指),并以它们为中心,建构起具有等级秩序的逻各斯中心主义。要解构逻各斯中心主义,必须先解构其赖以生存的“可译性”基础。这样,解构问题转化为翻译问题。翻译,特别是语际翻译,见证、展现和诠释了能指与所指的分裂、所指/概念/意义自身的分裂、语言的(内部的和外部的)分裂以及文本的(内部的和外部的)分裂。在这一切发生的同时,翻译也撕裂了自身。它不再担“翻译”的名,而蜕化为无限暧昧的“变形”(transformation)概念,德里达用莎士比亚名剧《威尼斯商人》中的一句话“when mercy seasonsjustice”(情理兼顾)揭示了其内涵。     

医患关系的博弈分析

医患关系是医疗中最基本最重要的关系,也是最复杂的人际关系,建立良好的医患关系是保证医疗工作顺利进行的必备条件.但是这种关系从开始就是有矛盾的,在信息不对称的情况下分析医患关系的博弈情况及其原因,发现医患关系的核心是信任,它为创造和谐医患关系提出对策,并能促进构建和谐医患关系.     

The measurement problem revisited

Synthese - It has been realized that the measurement problem of quantum mechanics is essentially the determinate-experience problem, and in order to solve the problem, the physical state...     

儿童早期的母亲生活压力对其5岁行为问题的预测效应：链式中介分析

通过对107名幼儿及其母亲历时5年的5次追踪测量, 考察了儿童早期(9~38个月)母亲生活压力对5岁时儿童行为问题的预测效应及其作用机制。结果发现, 在儿童早期, 母亲生活压力具有相对的稳定性, 但引起母亲生活压力的主要生活事件排序有所变化; 儿童早期母亲生活压力对儿童行为问题的作用机制有两种方式：一方面表现为母亲生活压力对儿童5岁时的情绪症状和品行问题的直接效应; 另一方面表现为通过减少母亲积极养育行为进一步影响儿童情绪症状和同伴问题的间接效应; 此外, 儿童早期母亲生活压力还通过积极养育和儿童努力控制的链式中介作用对儿童过度活跃和亲社会行为产生影响。结论:母亲生活压力对儿童行为问题具有预测效应, 这种效应的机制包括母亲生活压力的直接效应以及通过积极养育、努力控制的间接效应。