Phosphodiesterase type 5 (PDE5) inhibition improves object recognition memory: indications for central and peripheral mechanisms

A promising target for memory improvement is phosphodiesterase type 5 (PDE5), which selectively hydrolyzes cyclic guanosine monophosphate (cGMP). In rodents, PDE5 inhibitors (PDE5-Is) have been shown to improve memory performance in many behavioral paradigms. However, it is questioned whether the positive effects in animal studies result from PDE5 inhibition in the central nervous system or the periphery. Therefore, we studied the effects of PDE5 inhibition on memory and determined whether compound penetration of the blood-brain barrier (BBB) is required for this activity. Two selective PDE5-Is, vardenafil and UK-343,664, were tested in the object recognition task (ORT) in both a MK-801- and scopolamine-induced memory deficit model, and a time-delay model without pharmacological intervention. Compounds were dosed 30 min before the learning trial of the task. To determine if the PDE5-Is crossed the BBB, their concentrations were determined in plasma and brain tissue collected 30 min after oral administration. Vardenafil improved object recognition memory in all three variants of the ORT. UK-343,664 was ineffective at either preventing MK-801-induced memory disruption or time-dependent memory decay. However, UK-343,664 attenuated the memory impairment of scopolamine. Vardenafil crossed the BBB whereas UK-343,664 did not. Further, co-administration of UK-343,664 and scopolamine did not alter the brain partitioning of either molecule. This suggests that the positive effect of UK-343,664 on scopolamine-induced memory decay might arise from peripheral PDE5 inhibition. The results herein suggest that there may be multiple mechanisms that mediate the efficacy of PDE5 inhibition to improve memory performance in tasks such as the ORT and that these involve PDE5 located both within and outside of the brain. To further elucidate the underlying mechanisms, the cellular and subcellular localization of PDE5 needs to be determined.     

Slope estimation and viewing distance of the observer

The overestimation of geographical slant is one of the most sizable visual illusions. However, in some cases estimates of close-by slopes within the range of the observer’s personal space have been found to be rather accurate. We propose that the seemingly diverse findings can be reconciled when taking the viewing distance of the observer into account. The latter involves the distance of the observer from the slope (personal space, action space, and vista space) and also the eye-point relative to the slope. We separated these factors and compared outdoor judgments to those collected with a three-dimensional (3D) model of natural terrain, which was within arm’s reach of the observer. Slope was overestimated in the outdoors at viewing distances between 2 m and 138 m. The 3D model reproduced the errors in monocular viewing; however, performance was accurate with stereoscopic viewing. We conclude that accurate slant perception breaks down as soon as the situation exits personal space, be it physically or be it by closing one eye.     

Addressing Issues in the Development and Use of the Composite International Reference Values as Rorschach Norms for Adults

This article describes 3 studies evaluating normative reference data for the Rorschach Comprehensive System (CS; Exner, 2003, 2007), with a particular focus on the viability of the Composite International Reference Values (CIRVs) that were compiled from 21 adult studies by Meyer, Erdberg, and Shaffer (2007). Study 1 documented how the CIRV norms are virtually identical when organized into 3 groups differentiated by the quality of their data collection effort, including an optimal group of 4 samples that relied on multiple experienced examiners and provided ongoing quality control over administration and coding. Analyses also showed that relative to the group of more optimal samples, the group of less optimal samples did not produce more variability in summary scores within or across samples or lower interrater reliability for coding. Study 2 used the existing CS reference norms to generate T scores for the CIRV means and documented how the CS norms make other samples of healthy nonpatients look psychologically impaired in multiple domains. Study 3 documented with examples from 4 different countries how 2 sets of within-country local norms produced notably different results on some variables, which compromises the ability of local norms to be used instead of the CIRVs. Taken together, the 3 studies provide support for the use of CIRVs in clinical practice as norms that are generalizable across samples, settings, languages, and cultures and that account for the natural variability that is present when clinicians and researchers contend with the ambiguity contained in the standard CS reference materials concerning the proper ways to administer and code. We conclude by urging CS users to rely on the CIRVs when making clinical inferences and to adopt alternative methods of ensuring they are following cohesively standardized administration and coding guidelines.     

A Qualitative Examination of the Relationship Between Body Image and Sexual Behavior: Perceptions from Latina and African American Adolescent Girls and Their Maternal Caregivers

Although prior work suggests that how adolescent girls feel about their body is associated with their sexual behavior, we have less insight into the reasons why. We conducted semi-structured interviews with 25 African American adolescent girls (11–14 years of age), 18 Latina adolescents (14–17 years of age), and their maternal caregivers to explore why this association may exist. Both adolescent girls and their maternal caregivers were asked “Who is more likely to have sex, a girl who likes the way her body looks or a girl who doesn’t like the way her body looks?” A similar question was asked about condom use. Interviews were digitally recorded, transcribed, and coded for emergent themes using thematic analysis. Participants’ responded that both girls with a positive body image and those with a negative body image may be likely to have sex because of self- and body-esteem. Two sub-themes emerged that further explained why low self- and body-esteem mattered for girls who have a negative perception of their body: (a) feeling appreciated (b) easily persuaded. Most participants noted that girls with a positive body image perception would be more likely to use condoms. Emergent themes for using condoms were: (a) pregnancy/STI protection; and (b) body preservation. Our findings have implications for empirically exploring the pathways through which body image perceptions relate to adolescent sexual behaviors, and the possibility that universal prevention programs may not resonate similarly for all adolescent girls.     

Mind the Gap: Framing of Women’s Success and Representation in STEM Affects Women’s Math Performance under Threat

Interventions designed to combat the negative effects of stereotype threat have primarily taken an individual-based approach. The current study sought to expand upon these strategies by taking a group-based approach to reduce stereotype threat effects. Specifically, we investigated whether the success and numerical representation of women in STEM positively impacts women’s math performance and affective reactions. We hypothesized that 1) women under threat (control) would perform worse than men; 2) there would be a larger performance difference for women than men when exposed to the success and balanced representation of women in STEM compared to the control condition; 3) there would be a larger performance difference for women than men between the balanced condition and the unbalanced condition where women are portrayed as successful, but not equally represented in STEM. For this study, male (n?=?56) and female (n?=?66) U.S. undergraduates from a large southern California state university read information about women’s success and representation in STEM (or no information), completed a math exam under stereotype threat conditions, and then expressed their threat-based concerns. Results revealed that women performed worse than men in the control condition. Women in the balanced condition performed better than women in the control and unbalanced conditions. Men’s performance was unaffected by the balance or imbalance of women in STEM. Women’s affective reactions largely mirrored the performance results. This study provides compelling evidence for using a group-based approach highlighting women’s advances in STEM to alleviate stereotype threat.     

A taxometric analysis of actual Internet sports gambling behavior

This article presents findings from the first taxometric study of actual gambling behavior to determine whether we can represent the characteristics of extreme gambling as qualitatively distinct (i.e., taxonic) or as a point along a dimension. We analyzed the bets made during a 24-month study period by the 4,595 most involved gamblers among a cohort of 48,114 people using an Internet service to gamble on sporting events. We applied two taxometric procedures (i.e., MAMBAC and MAXCOV) to three indicators of betting behavior: total money lost, total number of bets, and total money wagered. The results fail to provide support for the view that the most involved Internet sports gamblers include a distinct category of gamblers. More research is necessary to clarify the similar features of recreational and extreme gamblers and the dimensions that scientists can use to measure these behaviors. Finally, we discuss the implications of these findings for clinical, research, and public policy activities.     

A Comparison of Firefighters and Police Officers: The Influence of Gender and Relationship Status

Differences between fire department and police department personnel (N = 190) concerning work‐related stressors and depression were examined with regard to gender and relationship status. Participants completed the Beck Depression Inventory—II (A. T. Beck, R. A. Steer, & G. K. Brown, 1996) and the Distressing Event Questionnaire (E. S. Kubany, M. B. Leisen, A. S. Kaplan, & M. P. Kelly, 2000). Recommendations are made concerning what crisis theories, both traditional and nontraditional, counselors should be aware of, as well as how simply working with trauma survivors can be traumatizing. E. Erikson's psychosocial stages (as cited in J. R. Studer, 2007) are considered in the framework of adult development.