d-Serine facilitates the effects of extinction to reduce cocaine-primed reinstatement of drug-seeking behavior

Male Sprague Dawley rats were allowed to self-administer cocaine (0.5 mg/kg) during 90 min sessions for a period of 15 days. On day 16, rats were either held abstinent in their home cage environment or experienced an extinction session in which the active lever had no programmed consequences. Facilitating N-methyl-d-aspartate (NMDA) receptor activity with the coagonist d-serine (100 mg/kg i.p.) before or following the extinction session significantly reduced the subsequent cocaine-primed reinstatement of drug-seeking behavior tested on day 17. d-Serine significantly reduced drug-primed reinstatement only when combined with extinction, and its effectiveness when administered following the training session suggested that an enhancement of consolidation of extinction learning had occurred. In contrast, d-serine treatment did not reduce sucrose-primed reinstatement, indicating that the beneficial effects of this adjunct pharmacotherapy with extinction training were specific to an addictive substance (cocaine) and did not generalize to a natural reward (sucrose).     

Electromyographic evidence for response conflict in the exclude recognition task

How do memory retrieval processes lead to overt responses in strategic recognition tasks (responding “old” to one class of familiar stimulus and “new” to another)? Many current theories of memory retrieval ignore the response requirements in such memory tasks, instead modeling them using memory processes (e.g., familiarity and recollection) alone (see Yonelinas, 2002). We argue that strategic recognition involves conflict in response processing similar to canonical conflict tasks (e.g., the Stroop task). The parallel task set (PTS) model (Seymour, 2001) accounts for performance in strategic recognition tasks (e.g., the exclude recognition task) by suggesting that motor response conflict occurs when one responds “new” to familiar stimuli. We tested this prediction using surface electromyography, a measure incontrovertibly related to motor execution. Overall, results are consistent with the PTS model’s assumption that recognition, motor, and control processes interact in strategic retrieval tasks. The implications of these data for models of memory retrieval and response conflict are discussed.     

Psychological Aspects of Genetic Counseling. X. Advanced Counseling Techniques

Four procedures commonly used by experienced counselors are described: simple interview formulations, helping clients think through their problems, reframing, and role playing. Each procedure is illustrated by examples. Among other things, the goal of these procedures is to promote the autonomy and self-directedness of clients and thus are particularly valuable in circumstances requiring a nondirective stance. The need is underscored for a more active counseling stance appropriate to the psychological and problem-solving needs of genetic counselees.     

The identification of stuttering: Can you look and tell

This investigation focussed on how observers identify stutterers. It was found that stutterers are identified most correctly under visual circumstances as compared to auditory and combined auditory-visual conditions. Therefore, the reduction of stuttering should include removal of noticeable, interfering, and unnecessary nonverbal behaviors, particularly mouth and nostril movements.     

Semantic distance effects in naming superordinates

The time to select a superordinate label in response to a target word is shown to be a function of the normative likelihood of the target being produced as an exemplar of the superordinate. This extends the scope of semantic distance effects to a new task situation. The effect declines with practice (repetition) and is also reduced by other preceding tasks. Two alternative accounts of the processing underlying selection are discussed.     

Synchronization of unimanual and bimanual responses with monotic and dichotic clicks

In experiments requiring subjective judgments, the apparent rate of rapidly presented dichotically alternating clicks has consistently been shown to be slower than that of clicks presented monotically. The first of the present studies asked (1) if slowing of dichotic clicks would be observed when the listener’s task was to “follow” the clicks with overt motor responses (unimanual keypresses) rather than to make psychophysical judgments, and (2) if following of dichotic clicks could be improved by providing two response channels (alternating bimanual presses). Both answers were affirmative. The second study asked (3) if the improvement obtained in the bimanual condition reflected increased perceptual capacity. The results indicated that it did not, but was attributable to an increase in response ceiling.     

On methods in the analysis of profile data

This paper is concerned with methods for analyzing quantitative, non-categorical profile data, e.g., a battery of tests given to individuals in one or more groups. It is assumed that the variables have a multinormal distribution with an arbitrary variance-covariance matrix. Approximate procedures based on classical analysis of variance are presented, including an adjustment to the degrees of freedom resulting in conservativeF tests. These can be applied to the case where the variance-covariance matrices differ from group to group. In addition, exact generalized multivariate analysis methods are discussed. Examples are given illustrating both techniques.We are indebted to Mrs. Norma French for performing all the calculations appearing in this paper.     

Views on the NAS/NAE/IM convocation on scientific conduct

The author is the recipient of the Herman Halperin Electric Transmission and Distribution Award, IEEE; United States Activities Board Professional Leadership Award, IEEE; United States Activities Board Citation of Honor, IEEE; Philip Sporn Award, Cigré; Atwood Associate, Cigré. J.A. Casazza has established the Peter Cooper Fund for Advancing Government Technical Competitions at Cooper Union.