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861.
Lauren K. Graham Taejib Yoon Jeansok J. Kim 《Learning & memory (Cold Spring Harbor, N.Y.)》2010,17(1):1-4
Stress is a biologically significant social–environmental factor that plays a pervasive role in influencing human and animal behaviors. While stress effects on various types of memory are well characterized, its effects on other cognitive functions are relatively unknown. Here, we investigated the effects of acute, uncontrollable stress on subsequent decision-making performance in rats, using a computer vision-based water foraging choice task. Experiencing stress significantly impaired the animals'' ability to progressively bias (but not maintain) their responses toward the larger reward when transitioning from equal to unequal reward quantities. Temporary inactivation of the amygdala during stress, however, blocked impairing effects on decision making.It is now well documented that exposure to uncontrollable stress can produce alterations in multiple brain–memory systems in humans and animals (McEwen and Sapolsky 1995; Kim and Diamond 2002; Joels et al. 2006; Shors 2006; Luethi et al. 2008). In humans, impairments in long-term, but not short-term, verbal recall tasks have been observed in people with post-traumatic stress disorder (PTSD) (Bremner et al. 1995) or Cushing''s disease (a hypercortisolemia condition) (Starkman et al. 1992) and in healthy individuals subjected to stress (Lupien et al. 1997) or exposed to stress levels of cortisol (Newcomer et al. 1994). In rodents, stress and corticosterone administration interfere with spatial and working memory (Diamond and Rose 1994; de Quervain et al. 1998; Kim et al. 2001) and potentiate aversive conditioning (Shors et al. 1992; Maier et al. 1995). Further, a number of stress-associated neurobiological changes have been identified (e.g., in hippocampus, medial prefrontal cortex, and amygdala) subserving different memory functions (Arnsten and Goldman-Rakic 1998; Kim and Yoon 1998; Vyas et al. 2003; Holmes and Wellman 2009).Although stress effects on memory have been well studied, far less is known about whether (and in what manner) stress influences other higher cognitive functions. The present study investigated the effects of acute, uncontrollable stress (60-min restraint + 60 intermittent tailshocks) on subsequent decision-making performance in rats. The stress procedure, in which animals learn that they can neither escape nor predict an aversive experience, was adapted from earlier studies (e.g., Maier and Seligman 1976; Kim et al. 1996). Decision making was assessed using an automated Figure-8-shaped maze on which rats were motivated to forage for water rewards in two different locations under equal and unequal quantity conditions (Fig. 1). In addition to behavioral stress, we examined the effects of corticosterone administration and inactivation of the amygdala during stress on decision making. Both corticosterone (a glucocorticoid hormone released in response to stress) and the amygdala (a structure crucial in defensive behavior) have been implicated in mediating neurocognitive effects of stress (McEwen and Sapolsky 1995; Kim and Diamond 2002).Open in a separate windowFigure 1.Decision-making task. Thirst-motivated rats were trained to forage for water on an automated Figure-8-shaped maze. A computer algorithm controlled the raising and lowering of four gates (represented by rectangles), the delivery of water (blue circles), and tracking of the animal''s location on the maze. During the baseline days, both left and right sides of the maze presented 0.04 mL of water at 80% probability (equal reward trials). Following each trial (a left or right loop), the animal returned to the center bridge to start the next trial (40 trials per day). During the bias test days, one side of the maze (counterbalanced) offered 0.12 mL of water at 80% probability, while the other side continued to present 0.04 mL of water at 80% probability (unequal reward trials). Animals received either stress, CORT injections, or neither (for group details, see text).Experimentally naïve male Charles River Sprague–Dawley rats (initially weighing 275–300 gm) were singly housed and maintained on a reverse 12-h light-dark cycle (lights on at 19:00 h). After 7 d of acclimation and for the duration of the experiment, daily water access was restricted to maintain approximately 85% of the animal''s normal body weight. Food was available ad libitum throughout the experiment. All experiments were conducted during the dark phase of the cycle and in strict compliance with the University of Washington Institutional Animal Care and Use Committee guidelines. Under anesthesia (30 mg/kg ketamine and 2.5 mg/kg xylazine, i.p.) amygdala (AMYG) animals were chronically implanted with 26-gauge guide cannulae (Plastics One) bilaterally into the amygdala (from bregma: anteroposterior, −2.3 mm; mediolateral, ±5 mm; dorsoventral, −7.7 to 8.0 mm). During 10–15 d of postoperative recovery, each dummy cannula was removed and replaced with a clean one.Muscimol free base (Sigma-Aldrich), dissolved in artificial cerebrospinal fluid (10 mM at pH ∼7.4), was microinfused into the amygdala (bilaterally) via 33-gauge infusion cannulae that protruded 1 mm beyond the guide cannulae (cf. Kim et al. 2005). An infusion volume of 0.3 μL (per side) was delivered using a Harvard PHD2000 syringe pump (Harvard Apparatus) over the course of 3 min. Animals were returned to their home cages for 30 min before undergoing the stress procedure. We based the timing of inactivation on previous findings that pre-stress but not immediate post-stress inactivation of the amygdala interferes with stress effects on hippocampal long-term potentiation (LTP) and spatial memory (Kim et al. 2005). Based on studies that examined 3H-muscimol spreading (Krupa et al. 1993; Arikan et al. 2002) in the cerebellum, in which 1 μL diffused a radius of 1.6–2.0 mm, it was estimated that 0.3 μL of muscimol would spread within a radius of approximately 0.5–0.7 mm from the infusion needle tip. Hence, it is likely that infused muscimol would have diffused to the central, lateral, and basal nuclei of the amygdala and possibly to portions of adjacent neighboring structures. The BODIPY TMR-X muscimol conjugate (Invitrogen) was infused in the same manner as muscimol free base (cf. Allen et al. 2008) to image the spread of reversible amygdalar inactivation.Corticosterone (CORT) animals received three daily subcutaneous injections of 3 mg/kg corticosterone (suspended in sesame oil; Sigma-Aldrich) 30 min prior to bias testing.Rats undergoing stress were restrained in Plexiglas tubes and presented with 60 tailshocks (1-mA intensity, 1-sec duration, 5- to 115-sec variable intershock interval) for 60 min (Kim et al. 2005). Animals were divided into four groups: control, stress, amygdalar inactivation plus stress (AMYG), and daily corticosterone (CORT).Following 2 d of habituation (to transport, maze, and room ambiance), all animals underwent successive shaping and testing phases. The dimensions and automatic features of the Figure-8 maze have been described previously (Pedigo et al. 2006; Yoon et al. 2008); for details, see Supplemental material. During shaping, each rat is placed into the center runway with all four gates in the up position (Supplemental Fig. S1). After 3 sec, the front and one of the side gates drop, until the rat on its own volition moves out of the center and onto the open side runway. At this point, the lowered front and side gates rise (to prevent the rat from going backward), water is delivered to both the open arm and the center spout, and the back gate drops. The rat consumes water from the open arm, and a new trial begins when he returns to and consumes water from the center arm. There was a 3-sec delay between each trial. During shaping, left and right choices were thus forced choices and were presented in a pseudorandom pattern, such that there was an equal number of both in a complete session (40 laps). Rats underwent shaping once daily until they met predetermined criteria: completion of 40 laps in less than 30 min, and less than five back edge errors (i.e., after making a choice, running up the opposite arm instead of going back to the center arm). The automated program controlled the gates and water delivery, according to the rat''s position on the maze.During baseline testing (Supplemental Fig. S2), the rewards dispensed on left and right arms were equal in both volume (0.04 mL) and probability (0.8). Each rat remained on baseline testing until he demonstrated a stable left/right choice pattern across three consecutive days. If a slight preference to one side was present, the opposite arm would be the increased reward side when bias testing commenced.Stress and AMYG rats were exposed to restraint + tailshock stress 1 d before their first bias test, and CORT rats were given corticosterone injections 30 min prior to each bias test. During bias testing (Supplemental Fig. S3), the reward value on one side was tripled in volume (0.12 mL) while the value for the other side remained constant (0.04 mL). Control, AMYG, and CORT animals were given three consecutive days of bias tests, while stress animals underwent six consecutive days of bias tests.At the completion of behavioral testing, animals were overdosed with urethane and perfused intracardially with 0.9% saline followed by 10% buffered formalin. The brains were removed and stored in 10% formalin overnight and then kept in 30% sucrose solution until they sank. Transverse sections (50 μm) were taken through the extent of the cannulae tract, mounted on gelatin-coated slides, and stained with cresyl violet to verify cannulae placements.The visit number to the left (or right) side of the maze for baseline and bias days were normalized to the mean left (or right) visits across the three baseline days. Statistical comparisons between groups were examined using ANOVA. For a significant difference (P < 0.05), post-hoc comparisons were performed using Tukey''s honestly significant difference test.Thirst-motivated rats readily learned to forage for water on the maze, and when left and right sides of the maze provided the same quantity (0.04 mL) and probability (80%) of water, the animals made comparable numbers of left and right visits (during 40 laps daily) that were stable across three baseline days (Fig. 2A). The 80% probability (a partial reinforcement schedule) was used so that animals frequently explored both sides of the maze. After animals demonstrated stable baseline choices, the volume of water on one side was tripled (0.12 mL at 80%), while the other side remained constant (0.04 mL at 80%). Overall, bias performance (choice of the larger reward) increased across the first three bias test days (repeated-measures ANOVA; main effect of day, F(2,54) = 78.16, P < 0.001). However, the four groups differentially increased their bias across days (group × day interaction, F(6,54) = 4.14, P < 0.01). Specifically, stressed rats displayed a significantly slower rate of bias toward the larger reward than did the controls (P < 0.01, Tukey). The stressed rats did ultimately develop a bias compared with their baseline choices (F(6,62) = 8.44, P < 0.001). This bias was first significant on the fourth day (P < 0.05, Dunnett t-test). However, even after 6 d of bias testing, their bias (127 ± 5.7%, mean ± SEM) did not reach the level of controls'' third day bias (182 ± 12.2%). Unlike the behavioral stress group, however, animals that received three daily corticosterone injections (3 mg/kg, subcutaneously) prior to testing chose the larger reward side more frequently (173 ± 6.7%, bias day 3) and did not differ from the control group (P > 0.7, Tukey). When the amygdalae were inactivated during stress (Fig. 3), these animals behaved like controls (P > 0.7, Tukey) and increased their visit frequency toward the larger reward side of the maze (174 ± 13.0%, bias day 3) (Fig. 2A). Although control, CORT, and AMYG animals developed strong bias responses, they did not exclusively visit the larger reward side of the maze because on 20% of trials they did not receive a reward.Open in a separate windowFigure 2.Stress effects on decision making. (A) All groups of animals showed comparable visits to left and right sides of the maze during the three baseline days. When transitioning from equal to unequal reward trials, stressed rats (n = 7) displayed an impaired ability to bias their responses toward the larger reward side compared with control (n = 10), AMYG (n = 7), and CORT (n = 7) rats (P = 0.002, group × bias day interaction). (B) Example visit maps of a control rat during baseline and bias days (40 laps each).Open in a separate windowFigure 3.(Top) Histological reconstruction of injection cannulae placement tips in the amygdala. (Bottom) A photomicrograph of fluorophore-conjugated muscimol (0.3 μL over 3 min) spread in the amygdala. The red fluorescence is overlaid with a dark field image.We then examined whether stress might have produced alterations in motor, motivation, and reference memory performances that hindered the animals'' ability to bias their responses toward the larger reward. The latency to complete 40 laps of the first bias test session (Supplemental Fig. S4A) showed a trend of stress animals completing the bias test faster than the other three groups, but this group × day interaction was not significant (F(6,54) = 1.89, P > 0.05). Stress also did not impair the animals'' reference memory of the maze (Supplemental Fig. S4B). That is, after making a left or right visit, stressed animals readily re-entered the center runway to start the next trial (one-way ANOVA; average baseline and first three bias days, F(3,41) = 0.20, P > 0.8), whereas control, CORT, and AMYG animals displayed an increased propensity to investigate the other side before re-entering the center, particularly as bias testing progressed (repeated-measures ANOVA; main effect of day, F(2,54) = 4.84, P < 0.05).Our results indicate that rats clearly demonstrate the capacity to change their foraging behavior to acquire a larger water reward when transitioning from equal to unequal quantities, and that such behavioral flexibility is vulnerable to acute, uncontrollable stress. Specifically, rats that experienced 1 h of restraint stress + 60 intermittent tailshocks were significantly impaired in biasing their responses toward the side of the maze with a larger quantity of water. This effect on bias was not due to any lingering post-stress motivational or motor effects, as stress did not increase the latency to complete the bias test. Daily corticosterone injections did not interfere with this task, indicating that corticosterone elevation per se cannot reproduce behavioral stress effects on behavioral flexibility. However, similar to previous stress–memory studies (Kim et al. 2001; Waddell et al. 2008), amygdalar inactivation during stress effectively blocked this effect. This suggests that the amygdala plays a crucial role in mediating stress effects across different cognitive domains.Although stress altered the rats'' behavior in our choice-based task, it remains unclear precisely which neural and cognitive systems were affected. For instance, the impairment of behavioral flexibility might be an indirect consequence of stress effects on hippocampal memory functioning. The stress paradigm used here is known to impede LTP in the CA1 hippocampus and hinder spatial memory (Foy et al. 1987; Kim et al. 2001). However, corticosterone, which also impedes LTP (McEwen and Sapolsky 1995) and spatial memory when administered 30 min before testing (de Quervain et al. 1998), did not impair behavioral flexibility. The impairment to choose the larger reward may be due to stress effects on working memory, such that the rats cannot remember (and thus learn) that one reward is larger. However, if true, the stress-induced memory impairment is unusually persistent in our task: Rats were affected through at least 6 d beyond the stress exposure. Because acquisition and retrieval of information are integral components of decision making, the contribution of stress-associated changes in learning and memory cannot be fully excluded. Another possibility is that stressed rats are more likely to use habitual rather than flexible strategies, even when a change in behavior may be optimal. Consistent with this explanation are recent findings that chronic stress exposure increases habit-based responding, with corresponding atrophy and hypertrophy of goal-directed and habit-based neural circuitry, respectively (Dias-Ferreira et al. 2009). The reliance on habit memory is also increased following anxiogenic drug infusions into the amygdala (Elliott and Packard 2008), which further implicates amygdalar modulatory activity during and after stress exposure in decreasing flexible behavior. If the stress experience did increase perseverative choice behavior, this may partially explain previously observed associations between distress and perseveration in humans (Robinson et al. 2006). Alternately, stress may have disrupted the reward circuitry and impaired the ability to discriminate between the two reward values from the two side arms, in which case stress effects on a dopamine-related reward circuit (Schultz et al. 1997) should be explored. However, this cannot be the sole explanation because post-bias stress did not affect the animals'' bias behavior toward the larger reward (Supplemental Table S1), and nonstressed rats resume equal arm visits when rewards are returned to baseline values (data not shown).The present findings reveal that a single exposure to an acutely stressful experience is enough to affect an animal''s behavior on a simple forging task for several days. There is accumulating evidence that exposure to stress increases amygdala and decreases prefrontal activity in both humans and animals (for review, see Arnsten 2009) and that even a single stress exposure alters cellular morphology in prefrontal cortex (Izquierdo et al. 2006). This shift in neural activity may promote the use of one cognitive strategy over another (e.g., habitual versus flexible). To address this, future studies need to investigate brain structures implicated in decision making, including the prefrontal and the parietal cortices (Gold and Shadlen 2007; Lee 2008), for their susceptibility to stress. Regardless, the present findings, to our knowledge, provide the first direct evidence that acute uncontrollable stress persistently impairs decision-making performance in animals and that this effect is dependent upon amygdalar activity during stress. 相似文献
862.
The Association of Psychologists in Academic Health Centers (APAHC) offers programming at the annual American Psychological
Association (APA) conventions as well as periodic APAHC conferences. Participants from academic health centers across the
country convened in St. Louis, Missouri, October 15–17, 2009, for the 4th National Conference of the Association of Psychologists
in Academic Health Centers (APAHC). The title of the conference was ‘‘Psychologists in Academic Health Centers: Facing Tomorrow’s
Challenges to AHC Programs and Careers.’’ Efforts were made to include topics relevant to academic health center (AHC) practice
including the unique challenges of working in AHCs and issues pertinent to the different stages of AHC careers. To facilitate
networking, opportunities for discussion among conferees and presenters with shared interests and concerns were provided throughout
the conference. This paper introduces the special section of JCPMS dedicated to the conference and provides a brief overview
of its development and organization. Articles selected for inclusion represent a sampling of the four conference themes: (1)
challenges to AHC programs, (2) staying current in critical clinical areas, (3) professional issues and challenges, and (4)
challenges to developing careers. Post-conference evaluation data are presented as evidence of the need for further conferences
with similar foci. The programming offered by APAHC at the APA convention in San Diego in 2010 built on the themes offered
at the 2009 APAHC conference. 相似文献
863.
Schwartz SJ Weisskirch RS Hurley EA Zamboanga BL Park IJ Kim SY Umaña-Taylor A Castillo LG Brown E Greene AD 《Cultural diversity & ethnic minority psychology》2010,16(4):548-560
The present studies examined the extent to which (a) communalism, familism, and filial piety would pattern onto a single family/relationship primacy construct; (b) this construct would be closely related to indices of collectivism; and (c) this construct would be related to positive psychosocial functioning and psychological distress. In Study 1, 1,773 students from nine colleges and universities around the United States completed measures of communalism, familism, and filial piety, as well as of individualistic and collectivistic values. Results indicated that communalism, familism, and filial piety clustered onto a single factor. This factor, to which we refer as family/relationship primacy, was closely and positively related to collectivism but only weakly and positively related to individualism and independence. In Study 2, 10,491 students from 30 colleges and universities in 20 U.S. states completed measures of communalism, familism, and filial piety, as well as of positive psychosocial functioning and psychological distress. The family/relationship primacy factor again emerged and was positively associated with both positive psychosocial functioning and psychological distress. Clinical implications and future directions for the study of cultural values are discussed. 相似文献
864.
This study investigated whether the positive effects of gestures on learning by decreasing working memory load, found in children and young adults, also apply to older adults, who might especially benefit from gestures given memory deficits associated with aging. Participants learned a problem‐solving skill by observing a video‐based modeling example, with the human model using gesture cues, with a symbolic cue, or without cues. It was expected that gesture compared with symbolic or no cues (i) improves learning and transfer performance, (ii) more in complex than simple problems, and (iii) especially in older adults. Although older adults' learning outcomes were lower overall than that of children and young adults, the results only revealed a time‐on‐task advantage of gesture over no cues in the learning phase for the older adults. In conclusion, the present study did not provide strong support for the effectiveness of gestures on learning from video‐based modeling example. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
865.
866.
867.
Brian?R.?Bryant Minwook?Ok Eun?Young?Kang Min?Kyung?Kim Russell?LangEmail author Diane?Pedrotty?Bryant Kathleen?Pfannestiel 《Journal of Behavioral Education》2015,24(2):255-272
Instructional applications (apps) are educational software programs that can be accessed via mobile technologies (e.g., iPad, smartphone) and used to help students acquire various academic skills, including mathematics. Although research suggests that app-based instruction (AI) can be effective, there is a paucity of research comparing AI, to teacher-directed instruction (TDI) or to a combination of instructional approaches (CI) involving both AI and TDI in tandem. In an alternating treatments design, we compared AI, TDI, and CI conditions during instruction targeting multiplication facts with six students with learning disabilities. Results were inconsistent across students, and no condition emerged as consistently better than the others. Students completed social validity rating scales, and all approaches were favored by at least one student. Our results support findings from previous research involving similar comparisons between these instructional formats in which no (or minimal) differences across conditions were detected. We conclude that there may not be a meaningful difference between the outcomes achieved using AI, TDI, or CI for many students. Results are discussed in terms of directions for the future research. 相似文献
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Visual perceptual learning (VPL) can occur as a result of a repetitive stimulus-reward pairing in the absence of any task. This suggests that rules that guide Conditioning, such as stimulus-reward contingency (e.g., that stimulus predicts the likelihood of reward), may also guide the formation of VPL. To address this question, we trained subjects with an operant conditioning task in which there were contingencies between the response to one of three orientations and the presence of reward. Results showed that VPL only occurred for positive contingencies, but not for neutral or negative contingencies. These results suggest that the formation of VPL is influenced by similar rules that guide the process of Conditioning. 相似文献
870.
Theories of ethical leadership provide important insights about the effect of leader’s ethics on the relationship between leaders and followers. However, there is an increasing demand for addressing key constructs that enhance the capacity to explain theoretical aspects of ethical leadership. The purpose of this study is to expand the theoretical framework of ethical leadership based on Korean traditional leadership by focusing on personal cultivation, morality, and social responsibility. Using a framework of intrapersonal process as leadership and core value and competence as components of leadership, this study examines the ethical aspects of Korean traditional leadership and provides the implications to further develop the theory of ethical leadership. It is found that ethical integrity ensued from sugi (self-cultivation) is an essential precondition to develop leadership, and the core value of ethical leadership includes Zhixin-Chijing (cultivation of the mind and internal piety) and the competence consists of both Ipzhi (setting a solid self-vision/establishing goal) and Silsim (practical mind, grasp changes in reality with a sound mind) in Korean traditional leadership that contributes to expanding the theoretical understanding of ethical leadership. Implications for future research in the area of ethical leadership are discussed. 相似文献