Parkinson's disease protects against smoking?

Our aim was to estimate the pooled risk of current and former smoking for Parkinson's disease (PD). We have reviewed all observational studies that evaluated the association between PD risk and smoking habit. Twenty six studies were identified: 21 case-control, 4 cohort and 1 cross-sectional. The cross-sectional study did not compare former with never smokers. These studies were carried out between 1968 and 2000. There was an obvious protective effect of current smoking in the pooled estimate [risk estimate 0.37 (95% confidence interval 0.33 to 0.41)]. Former versus never smokers had pooled risk estimate of 0.84 (95% confidence interval 0.76 to 0.92). Current and former smoking do not, therefore, exert the same protective effect against PD so that it is unnecessary to postulate a biological mechanism through which smoking protects against PD. The results show that the reverse direction of causation is a more probable explanation, i.e. movement disorders of PD protect against smoking. Another explanation is that failure to develop strong smoking habits in early adult life might be a prodromal symptom of the disease and could perhaps be its first clinical manifestation.     

The role of neighborhood ecological assets and activity involvement in youth developmental outcomes: Differential impacts of asset poor and asset rich neighborhoods

Developmental system theories recognize that variables from multiple levels of organization within the bioecology of human development contribute to adolescent development, including individual factors, family factors and the neighborhood which includes extracurricular activities. Extracurricular activities provide a context for youth development, and participation has been linked with positive developmental outcomes. This study uses data from a subsample of early adolescents in the 4-H Study of Positive Youth Development to determine whether neighborhood assets moderate the effect of adolescent activity involvement on positive and negative developmental outcomes. The relationship between activity involvement and neighborhood assets was different for girls as compared to boys when assessing outcomes of positive youth development, risk behavior, and depression. Consistent with a developmental systems perspective, the findings affirm the need for researchers and practitioners to consider multiple contextual influences when seeking to understand or promote, respectively, positive youth development.     

Effects of Training Volume on Hormones and Mood in Basketball Players

Mood and basal hormone levels were measured before and after a 4-month training period in 20 professional basketball players on 2 different teams. Training volume was daily quantified by intensities, showing that Team 1 trained nearly twofold the volume of Team 2. Apart from the lack of differences between teams in anthropometric and physical variables, results showed mood improvements in the total sample without differences between teams. However, cortisol levels decreased in Team 1 and increased in Team 2, while the free testosterone–cortisol ratio, free testosterone, prolactin, and luteinizing hormone did not show significant changes. Changes in cortisol were positively related to depression and negatively related to training volume. Results suggest that differences exist in sensitivity and/or timing of both psychological and hormonal responses to 2 given volumes of training.     

Burnout in Spanish physiotherapists

Diverse works on health sciences emphasise the importance of burnout in specific jobs. However, there is a lack of research about the presence of this syndrome in Spanish physiotherapists. The aims of this study were to determine the prevalence of burnout among physiotherapists and the relationship with work-related factors. 462 questionnaires were sent to health-centres. The questionnaire of work-related factors was administered, as well as the Maslach burnout inventory (MBI). 258 responses were received (55.8% response rate) from Murcia and Valencia. Regarding results 10 (4%) physiotherapists showed severe burnout. In relation to work-related factors, significant differences were observed. Although the percentage of physiotherapists with severe burnout was relatively low, it is important take into account that the syndrome requires the combined presence of three dimensions, which implies a very relevant situation of mental deterioration.     

Neuropsychological evidence for "word-meaning deafness" in a Spanish-speaking patient

In this paper we present a case of "word-meaning deafness," characterised by serious problems in the comprehension of spoken language, whilst repetition and writing words and non-words from dictation are preserved. This performance indicates the impossibility of correctly accessing phonological representation from the semantic representation of words. Neuropsychological evidence on specific alterations in word-meaning disorders is scarce, and this study contributes new findings with a Spanish-speaking patient. The nature of the processes involved in understanding language and the cerebral mechanisms that might be affected in each case were discussed, in accordance with current neuropsychological theories.     

Hypothalamo-Pituitary-Adrenocortical Regulation Following Lesions of the Central Nucleus of the Amygdala

Previous reports indicate that the central nucleus of the amygdala (CeA) stimulates adrenocorticotropin and corticosterone secretion, suggesting a role for this region in central hypothalamo-pituitary-adrenocortical (HPA) stress regulation. To evaluate this hypothesis, this study assessed the impact of CeA lesion on the response of hypophysiotrophic paraventricular nucleus (PVN) neurons to acute restraint and chronic unpredictable stress exposure. In contrast to previous reports, CeA lesions did not affect corticosterone or ACTH secretion induced by acute stress. Acute restraint increased PVN corticotropin releasing hormone (CRH) mRNA expression, increased the number of parvocellular PVN neurons expressing the co-secretagogue arginine vasopressin (AVP), and induced cFOS mRNA expression in the parvocellular PVN. However, there was no additional effect of CeA lesion on any measure of PVN activation. Chronic unpredictable stress exposure induced long-term activation of the HPA axis, noted by thymic involution, adrenal hypertrophy and increased PVN CRH mRNA expression. Stress-induced changes in thymus and adrenal weights were not affected by CeA lesion. Further, CeA lesion rats did not differ from controls in post-stress CRH mRNA expression. However, basal CRH mRNA expression was increased in the PVN of CeA rats, suggesting that the CeA plays a role in long-term inhibition of the PVN. The results of these studies are not consistent with the hypothesis that the CeA is necessary for stress-induced pituitary-adrenocortical activation. Rather, this region may play a stressor-specific modulatory role in regulation of HPA function.     

Testing Whether and When Parent Alcoholism Uniquely Affects Various Forms of Adolescent Substance Use

The current study examined the distal, proximal, and time-varying effects of parents’ alcohol-related consequences on adolescents’ substance use. Previous studies show that having a parent with a lifetime diagnosis of alcoholism is a clear risk factor for adolescents’ own substance use. Less clear is whether the timing of a parent’s alcohol-related consequences differentially predicts the adolescent’s own substance involvement. Using a multilevel modeling approach, we tested whether adolescents showed elevated rates of alcohol, heavy alcohol, marijuana and other illegal drug use (a) at the same time that parents showed alcohol-related consequences (time-varying effects), (b) if parents showed greater alcohol-related consequences during the child’s adolescence (proximal effects), and (c) if parents had a lifetime diagnosis of alcoholism that predated the child’s adolescence (distal effects). We tested these effects in a high-risk sample of 451 adolescents assessed over three waves beginning at ages 11–15 from 1988 to 1991 (53?% male, 71?% non-Hispanic Caucasian, 54?% children of alcoholic parents and 46?% matched controls). Strong and consistent distal effects of parent alcoholism on adolescent’s substance use were found, though no additional risk was associated with proximal effects. Limited time-varying effects were also found. The importance of differentiating the timing effects of parent alcoholism in identifying underlying mechanisms of risk for adolescent substance use is discussed.     

Discrimination and categorization of emotional facial expressions and faces in Parkinson's disease

Our objective was to compare the ability to discriminate and categorize emotional facial expressions (EFEs) and facial identity characteristics (age and/or gender) in a group of 53 individuals with Parkinson's disease (PD) and another group of 53 healthy subjects. On the one hand, by means of discrimination and identification tasks, we compared two stages in the visual recognition process that could be selectively affected in individuals with PD. On the other hand, facial expression versus gender and age comparison permits us to contrast whether the emotional or non‐emotional content influences the configural perception of faces. In Experiment I, we did not find differences between groups, either with facial expression or age, in discrimination tasks. Conversely, in Experiment II, we found differences between the groups, but only in the EFE identification task. Taken together, our results indicate that configural perception of faces does not seem to be globally impaired in PD. However, this ability is selectively altered when the categorization of emotional faces is required. A deeper assessment of the PD group indicated that decline in facial expression categorization is more evident in a subgroup of patients with higher global impairment (motor and cognitive). Taken together, these results suggest that the problems found in facial expression recognition may be associated with the progressive neuronal loss in frontostriatal and mesolimbic circuits, which characterizes PD.