Individual characteristics and response to Contingency Management treatment for cocaine addiction

Voucher-based contingency management (CM) research has demonstrated efficacy for treating cocaine addiction, but few studies have examined associations between individual baseline characteristics and response to CM treatments. The aim of this study, involving 50 cocaine outpatients receiving CM for cocaine addiction, was to assess the impact of baseline characteristics on abstinence outcomes after six months of treatment. Patients who were abstinent after six months of treatment accounted for 58% of the sample. Patients with higher scores on the Alcohol area of the EuropASI and patients that were non-abstinent during the first month of treatment were less likely to achieve abstinence. These outcome predictors have implications both for treatment research and for clinical practice. Patients who do not respond early to treatment may need a more intensive intervention, and concomitant problematic alcohol use should be detected and treated. The remaining baseline variables examined were not statistically significant predictors of abstinence. This finding is important for the generalizability of CM across the range of individual characteristics of treatment-seeking cocaine abusers.     

Features of the selectivity for contrast polarity in contour integration revealed by a novel tilt illusion

We studied a novel illusion of tilt inside checkerboards due to the role of contrast polarity in contour integration. The preference for binding of oriented contours having same contrast polarity, over binding of opposite polarity ones (CP rule), has been used to explain several visual illusions. In three experiments we investigated how the binding effect is influenced by luminance contrast value, relatability of contour elements, and distance among them. Experiment 1 showed that the effect was indeed present only when the CP rule was satisfied, and found it to be stronger when the luminance contrast values of the elements are more similar. In experiment 2 the illusion was reported only with relatable edges, and its strength was modulated by the degree of relatability. The CP-rule effectiveness, thus, seems to depend on good continuation. The intensity of contrast polarity signals propagating from an oriented contour might be the less intense, the more its direction deviates from linearity. In experiment 3 we estimated the distance threshold and found it to be smaller than the one found for other illusions, arising with collinear fragments. This seems to show that the reach of the contrast polarity signal inside the association field of a contour unit is shorter along non-collinear orientations than along collinear ones.     

Arcs in perceptual space--going off at a tangent

Underestimating the curvature of an arc may result from our tendency to view it as prolonged in the direction of the tangent to its ends. Support is given here for this hypothesis, but evidence is also provided that tangent deviation may alter an arc's circularity along its whole length.     

Frontal Operators in Weak Heyting Algebras

In this paper we shall introduce the variety FWHA of frontal weak Heyting algebras as a generalization of the frontal Heyting algebras introduced by Leo Esakia in [10]. A frontal operator in a weak Heyting algebra A is an expansive operator τ preserving finite meets which also satisfies the equation ${\tau(a) \leq b \vee (b \rightarrow a)}$ , for all ${a, b \in A}$ . These operators were studied from an algebraic, logical and topological point of view by Leo Esakia in [10]. We will study frontal operators in weak Heyting algebras and we will consider two examples of them. We will give a Priestley duality for the category of frontal weak Heyting algebras in terms of relational spaces ${\langle X, \leq, T, R \rangle}$ where ${\langle X, \leq, T \rangle}$ is a WH-space [6], and R is an additional binary relation used to interpret the modal operator. We will also study the WH-algebras with successor and the WH-algebras with gamma. For these varieties we will give two topological dualities. The first one is based on the representation given for the frontal weak Heyting algebras. The second one is based on certain particular classes of WH-spaces.     

The emotional cost of charitable donations

Donations in support of a charitable cause can create a conflict between moral intuitions (e.g., fulfilling moral obligations and helping as many individuals in need as possible) and the cost entailed by following one's moral intuitions (e.g., spending money). The present paper investigates this conflict by putting people in a situation in which they must choose whether to help three women by giving more money or help one woman by giving less. In addition, the paper uses the attraction effect paradigm to counteract the single victim effect and reduce the conflict. Experiment 1 demonstrates that in a two-alternative context the majority of participants choose to help one woman by giving €150 instead of helping three women by giving €450. Experiment 2 replicates this finding and highlights the role of emotion regulation strategies in the management of the emotional conflict arising in the two-alternative condition. In both studies, the introduction of a third, dominated alternative reduces the conflict and makes it easier to choose the programme asking for a higher donation and helping three women. Implications for charitable donations and the role of the conflict between moral intuitions and economic costs are discussed.     

EEG oscillatory states as neuro-phenomenology of consciousness as revealed from patients in vegetative and minimally conscious states

The value of resting electroencephalogram (EEG) in revealing neural constitutes of consciousness (NCC) was examined. We quantified the dynamic repertoire, duration and oscillatory type of EEG microstates in eyes-closed rest in relation to the degree of expression of clinical self-consciousness. For NCC a model was suggested that contrasted normal, severely disturbed state of consciousness and state without consciousness. Patients with disorders of consciousness were used. Results suggested that the repertoire, duration and oscillatory type of EEG microstates in resting condition quantitatively related to the level of consciousness expression in brain-damaged patients and healthy-conscious subjects. Specifically, results demonstrated that (a) decreased number of EEG microstate types was associated with altered states of consciousness, (b) unawareness was associated with the lack of diversity in EEG alpha-rhythmic microstates, and (c) the probability for the occurrence and duration of delta-, theta- and slow-alpha-rhythmic microstates were associated with unawareness, whereas the probability for the occurrence and duration of fast-alpha-rhythmic microstates were associated with consciousness. In conclusion, resting EEG has a potential value in revealing NCC. This work may have implications for clinical care and medical-legal decisions in patients with disorders of consciousness.     

Toward operational architectonics of consciousness: basic evidence from patients with severe cerebral injuries

Although several studies propose that the integrity of neuronal assemblies may underlie a phenomenon referred to as awareness, none of the known studies have explicitly investigated dynamics and functional interactions among neuronal assemblies as a function of consciousness expression. In order to address this question, EEG operational architectonics analysis (Fingelkurts and Fingelkurts 2001, 2008) was conducted in patients in minimally conscious (MCS) and vegetative states (VS) to study the dynamics of neuronal assemblies and operational synchrony among them as a function of consciousness expression. We found that in minimally conscious patients and especially in vegetative patients neuronal assemblies got smaller, their life span shortened and they became highly unstable. Furthermore, we demonstrated that the extent/volume and strength of operational synchrony among neuronal assemblies was smallest or even absent in VS patients, intermediate in MCS patients, and highest in healthy fully conscious subjects. All findings were similarly observed in EEG alpha as well as beta1 and beta2 frequency oscillations. The presented results support the basic tenets of operational architectonics theory of brain–mind functioning and suggest that EEG operational architectonics analysis may provide an objective and accurate means of assessing signs of (un)consciousness in patients with severe brain injuries. Therefore, this methodological approach may complement the existing “gold standard” of behavioral assessment of this population of challenging patients and inform the diagnostic and treatment decision-making processes.     

A search for the physical content of Luders' rule

An interpretation of quantum mechanics that rejects hidden variables has to say something about the way measurement can be understood as a transformation on states of individual systems, and that leads to the core of the interpretive problems posed by Luders' projection rule: What, if any, is its physical content? In this paper I explore one suggestion which is implicit in usual interpretations of the rule and show that this view does not stand on solid ground. In the process, important aspects of the role played by the projection postulate in the conceptual structure of quantum mechanics will be clarified. It will be shown in particular that serious objections can be raised against the (often implicit) view that identifies the physical relation of compatibility preserved by Luders' rule with the relation of simultaneous measurability.     

Bilateral opercular syndrome and crossed aphemia due to a right insular lesion: A clinicopathological study

A right-handed male patient suddenly noted lower bilateral facial and lingual palsy, and inability to masticate and swallow, but with preserved automatic functions. He was mute, communicating only through writing, but verbal comprehension was normal (aphemia). On anatomopathological examination, an ischemic infarction of the entire right insula, with mild extension to the fronto-temporoparietal operculum was observed. The left hemisphere was normal. The clinical findings suggest a bilateral opercular syndrome due to a right hemisphere lesion and a crossed aphemia.