Endogenous cortisol level interacts with noradrenergic activation in the human amygdala

Animal studies show that high cortisol levels exert their effect on stressful task performance via modulation of the amygdala. Availability of noradrenaline in this brain region appears to be a critical prerequisite for this effect. This relationship between noradrenaline and cortisol is explained by an animal model where the amygdala constitutes a crucial region for this interaction. In humans this model has not been extensively tested so far. In a previously reported study human subjects (aged 20.93+/-2.38) were scanned using fMRI when watching sets of emotional and neutral pictures after taking the beta-adrenergic antagonist propranolol or placebo. Stimulus sets consisted of 92 pictures, divided in four emotional categories that ranged from neutral scenes of domestic objects (CAT1) to extremely negative scenes of mutilation or accidents (CAT4). Confrontation with arousing emotional pictures, accompanied by increased noradrenaline levels, evoked increased amygdala activation under placebo but not under betablocker condition. This new and additional analysis of this data set was carried out to determine the effect of differential endogenous cortisol levels on amygdala activation. Cortisol levels during scanning were determined using salivary samples and subjects were post hoc divided in a High (n=14) and Low cortisol group (n=14). When subjects were watching emotional stimuli, presumably associated with enhanced noradrenaline (NA) levels, amygdala activation was contrasted between the two cortisol groups. We hypothesized that emotional stimuli would elicit more amygdala activation in the High than in the Low cortisol group. Here we demonstrate indeed a significant interaction effect of the endogenous cortisol level with increasing activation in the amygdala under placebo but not under betablocker condition, thereby extending the rodent based model of a synergistic effect of the two stress hormones to the human.     

When memory shifts toward more typical category exemplars: accentuation effects in the recollection of ethnically ambiguous faces

In 4 studies, the authors examined the impact of categorization on the recollection of ethnically ambiguous faces. Participants were presented with faces lying at various locations on mixed-race continua (i.e., Caucasian-North African and Caucasian-Asian faces were used as source images in a morphing program). In all studies, the prevalence of exclusive ethnic features in a face distorted participants' recollections of the face toward faces more typical of the category. Specifically, the recollection of 30% North African (or 30% Asian) faces shifted toward Caucasian source faces, whereas the recollection of 70% North African (or 70% Asian) faces shifted toward North African (Asian) source faces. Memory distortions did not emerge for extremely ambiguous (50%) faces and proved larger on mixed-race than same-race continua (Studies 3 and 4). Memory distortions also emerged with high levels of confidence. The authors elaborate on the theoretical and practical implications of these findings.     

On the ethics of facial transplantation research

Transplantation continues to push the frontiers of medicine into domains that summon forth troublesome ethical questions. Looming on the frontier today is human facial transplantation. We develop criteria that, we maintain, must be satisfied in order to ethically undertake this as-yet-untried transplant procedure. We draw on the criteria advanced by Dr. Francis Moore in the late 1980s for introducing innovative procedures in transplant surgery. In addition to these we also insist that human face transplantation must meet all the ethical requirements usually applied to health care research. We summarize the achievements of transplant surgery to date, focusing in particular on the safety and efficacy of immunosuppressive medications. We also emphasize the importance of risk/benefit assessments that take into account the physical, aesthetic, psychological, and social dimensions of facial disfiguration, reconstruction, and transplantation. Finally, we maintain that the time has come to move facial transplantation research into the clinical phase.     

Social comparison, self-stereotyping, and gender differences in self-construals

Four studies examined gender differences in self-construals and the role of social comparison in generating these differences. Consistent with previous research, Study 1 (N=461) showed that women define themselves as higher in relational interdependence than men, and men define themselves as higher in independence/agency than women. Study 2 (N=301) showed that within-gender social comparison decreases gender differences in self-construals relative to a control condition, whereas between-genders comparison increases gender differences on both relational interdependence and independence/agency. Studies 3 (N=169) and 4 (N=278) confirmed these findings and showed that changing self-construal changes gender differences in social dominance orientation. Across the 4 studies, strong evidence for the role of in-group stereotyping as mediator of the effect of gender on self-construal was observed on the relational dimension but not on the agentic dimension.     

Effect of bilateral stimulation of the subthalamic nucleus on parkinsonian dysarthria

Never was the effect of bilateral stimulation of the subthalamic nucleus (STN) evaluated quantitatively on all the components of speech production, that is articulation, respiration and phonation, at the same time. It is the purpose of this study which uses force measurements of the articulatory organs and acoustic analysis in 16 parkinsonian patients. With STN stimulation, reaction and movement time of the articulatory organs decreased and their maximal strength, as well as their precision increased. We also noted a large beneficial effect on voice with a significant improvement in respiratory and phonatory functions.     

The origin of exemplar effects in rule-driven categorization

S. W. Allen and L. R. Brooks (1991) have shown that exemplar memory can affect categorization even when participants are provided with a classification rule. G. Regehr and L. R. Brooks (1993) argued that stimuli must be individuated for such effects to occur. In this study, the authors further analyze the conditions that yield exemplar effects in this rule application paradigm. The results of Experiments 1-3 show that interchangeable attributes, which are not part of the rule, influence categorization only when attention is explicitly drawn on them. Experiment 4 shows that exemplar effects can occur in an incidental learning condition, whether stimulus individuation is preserved or not. The authors conclude that the influence of exemplar learning in rule-driven categorization stems from the attributes specified in the rule or in the instructions, not from the stimulus gestalts.     

The effect of long-term working memory through personalization applied to free recall: Uncurbing the primacy-effect enthusiasm

In this study, a personalization method (Guida, Tardieu, & Nicolas, European Journal of Cognitive Psychology, 21: 862–896 2009) was applied to a free-recall task. Fifteen pairs of words, composed of an object and a location, were presented to 93 participants, who had to mentally associate each pair and subsequently recall the objects. A 30-s delay was introduced on half of the trials, the presentation rate was manipulated (5 or 10 s per item), and verbal and visuospatial working memory tests were administered to test for their effects on the serial curve. Two groups were constituted: a personalized group, for whom the locations were well-known places on their university campus, and a nonpersonalized group, for whom the locations did not refer to known places. Since personalization putatively operationalizes long-term working memory (Ericsson & Kintsch, Psychological Review, 102: 211–245 1995)—namely, the capacity to store information reliably and rapidly in long-term memory—and if we take a dual-store approach to memory, the personalization advantage would be expected to be greater for pre-recency than for recency items. Overall, the results were compatible with long-term working memory theory. They contribute to validating the personalization method as a methodology to characterize the contribution of long-term memory storage to performance in working memory tasks.     

Sources

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Glasnost, Christen und Genossen (Glasnost’, Christians and Comrades) edited by Norbert Sommer. Berlin: Wichern‐Verlag, 1988. Paperback, 188 pp.

Soviet Charismatics: the Pentecostals in the USSR by William C. Fletcher. New York: Peter Lang, 1985. 200 pp.

The KGB: Police and Politics in the Soviet Union by Amy W. Knight. London: Unwin Hyman, 1988. 348 pp.

Every Person is First of all a History by Fr Mykhaylo Havryliv. Rome: Ukrainian Press Service, 1987. 158 pp.

The Razing of Romania's Past by Diav C. Giurescu. New York: United States Committee/International Council on Monuments and Sites, 1989. 68 pp. plus photographs     

The Balance-Scale Dilemma: Either the Subject or the Experimenter Muddles Through

We examined two critiques of rule-assessment methodology: (a) the method does not take into consideration other rules that subjects use to solve problems, and (b) its multiple-choice format misrepresents subjects' cognitive level. In Study 1, high school students completed a paper-and-pencil, multiple-choice balance scale questionnaire. Their performance was assessed with Siegler's original rules and a revised set of rules that included an addition and a qualitative proportionality rule. Results showed that Siegler's Rule 3 was not homogeneous and that distinguishing specific patterns of answers among Rule 3 subjects increased the diagnostic value of the rule-assessment methodology. In Study 2, we compared rule-assessment methodology to the Piagetian clinical model. High school students solved balance-scale problems within each method. Results indicated an overall match between Piagetian levels and Siegler's rules, with the exception of Rule 3, suggesting again the pertinence of specifying alternative rules.     

Hierarchy and the Meaning of Working

Abstract

This study investigated the meaning of working for subjects from three levels of an organizational hierarchy. Staff members of a high technology manufacturing organization were surveyed using an abridged version of the Meaning of Working Questionnaire. Five central aspects of the ‘meaning of working’ concept were explored using this instrument, namely Work Centrality, Work Role Identification, Valued Working Outcomes, Societal Norms about Working, and Work Goals. Results show a high level of shared perceptions by members of the three hierarchical levels on ‘meaning of working’ variables, a finding which is at odds with past research, which for the most part indicates clear hierarchal effects. Such findings are discussed within the context of the internal processes of the organization as well as in a specific industry-wide framework.