The diagnostic role of serum inflammatory and soluble proteins on dementia subtypes: correlation with cognitive and functional decline

In the past years, the possible involvement of inflammation in the pathogenesis of dementia has been the subject of several investigations. However there are restricted data about the profile of the inflammatory and soluble proteins in well evaluated Alzheimer's disease (AD), vascular dementia (VD), mild cognitive impairment (MCI) and healthy controls. There are also no reliable data regarding the relationship between the overlapping protein levels and cognitive or functional decline. We measured levels of IL-1beta, IL-2, IL-6, IL-18, TNF-alpha, beta-Amlyloid 1-40 and alpha1-antichymotrypsin levels in plasma in groups of total 82 subjects with AD, MCI, VD and controls using enzyme-linked immunosorbent assay (ELISA) method. Our study samples showed high levels of proinflammatory cytokine levels (especially IL-18) in all patient groups but only high levels of alpha1-antichymotrypsine in VD patients compared to controls. There is no significant correlation between the laboratory and clinical variables except for a link between IL-1beta and NPI scores of AD. In conclusion, this study yielded evidence of some shared mechanisms underlying AD and VD and thus motivates further studies of inflammatory markers in various types of dementia and MCI.     

Can tutoring improve performance on a reasoning task under deadline conditions?

The present study examined the effectiveness of a tutoring technique that has been used to identify and address participants' misunderstandings in Wason's selection task. In particular, the study investigated whether the technique would lead to improvements in performance when the task was presented in a deadline format (a condition in which time restrictions are imposed). In Experiment 1, the effects of tutoring on performance were compared in free time (conditions in which no time restrictions are imposed) and deadline task formats. In Experiment 2, improvements in performance were studied in deadline task formats, in which the tutoring and test phases were separated by an interval of 1 day. The results suggested that tutoring improved performance on the selection task under deadline and in free time conditions. Additionally, the study showed that participants made errors because they had misinterpreted the task. With tutoring, they were able to modify their initial misunderstandings.     

Development and initial validation of the Self-harm Behavior Questionnaire.

Evaluation of suicide-related behaviors and thoughts about suicide with a newly developed self-report instrument is described. The Self-Harm Behavior Questionnaire (SHBQ; Gutierrez, 1998) generates detailed clinical information from an easy to administer and score self-report form. A sample of 342 participants were drawn from university undergraduate students enrolled in various psychology courses. Participants were then divided into a severe suicidal ideation group (n = 20) and a nonsuicidal control group (n = 20) to conduct subgroup and criterion-related validity analyses. Preliminary analyses indicate this new questionnaire is both valid and reliable when used with young adults drawn from a nonclinical population. The questionnaire should be of use to both clinicians and researchers due to the flexibility of the data generated.     

On the locus of speed-accuracy trade-off in reaction time: inferences from the lateralized readiness potential

Lateralized readiness potentials (LRPs) were used to determine the stage(s) of reaction time (RT) responsible for speed-accuracy trade-offs (SATs). Speeded decisions based on several types of information were examined in 3 experiments, involving, respectively, a line discrimination task, lexical decisions, and an Erikson flanker task. Three levels of SAT were obtained in each experiment by adjusting response deadlines with an adaptive tracking algorithm. Speed stress affected the duration of RT stages both before and after the start of the LRP in all experiments. The latter effect cannot be explained by guessing strategies, by variations in response force, or as an indirect consequence of the pre-LRP effect. Contrary to most models, it suggests that SAT can occur at a late postdecisional stage.     

Appropriateness of the Multi-Attitude Suicide Tendency Scale for non-White individuals

Analyses of data collected from 480 university students (approximately 56% White and 44% Black) challenge the utility of the Multi-Attitude Suicide Tendency Scale (MAST) for use with individuals of diverse cultural backgrounds. This size sample allowed for an examination of the psychometric properties and cultural relevance of the MAST for non-Whites. Correlations between scores on the MAST, suicide, and depression measures were in the expected directions for Whites but not for Blacks or Latinos. The White sample data fit the four-factor model of the MAST, but the model required several modifications to fit the data from the Black sample. Verification of the cultural relevance of the MAST and a revision of the scale are recommended to improve its usefulness.     

The Positive and Negative Suicide Ideation (PANSI) inventory: psychometric evaluation with adolescent psychiatric inpatient samples

In this study, we evaluated the factor structure of the Positive and Negative Suicide Ideation (PANSI) Inventory (Osman, Gutierrez, Kopper, Barrios, & Chiros, 1998) using confirmatory factor analysis (CFA). The PANSI assesses the frequency of negative risk and protective factors that are related to suicidal behavior. Participants (n = 195) were adolescent psychiatric inpatients, ages 14 to 17 years, in the CFA. Results of the CFA supported the fit for the 2-factor oblique model as the best fitting model. The internal consistency reliability estimates of the 2 subscales, the PANSI-Negative (alpha = .96) and the PANSI-Positive (alpha = .89) were high. Scores on the PANSI scales differentiated between suicide attempters and controls and those at severe risk for suicide and controls. Correlational analyses provide strong support for the concurrent validity of the scales. The results of the logistic regression analyses provide support for the use of this new inventory as a risk measure of suicide-related behaviors: Scores on the PANSI scales (n = 54) also showed satisfactory evidence for test-retest reliability over a 2-week period.     

There are stable individual differences in performance variability, both from moment to moment and from day to day

Individual differences in decision speed have been regarded as direct reflections of a "primitive" functional neurophysiological characteristic, which affects performance on all cognitive tasks and so may be regarded as the "biological basis of intelligence", or of age-related changes in mental abilities. More detailed analyses show that variability within an experimental session (WSV) is a stable individual difference characteristic and that mean choice reaction times (CRTs) are gross summary statistics that reflect variability, rather than maximum speed of performance. A total of 98 people aged from 60 to 80 years completed 36 weekly sessions on six different letter categorization tasks. After effects of practice and of circadian variability had been eliminated, individuals with lower scores on the Cattell Culture Fair intelligence test had slower CRTs and greater WSV on all tasks. A simulation study showed that the greater WSVs of low Cattell scorers led directly to the significantly greater variability of their mean CRTs from session to session. However because CRTs on tasks co-varied from session to session it was apparent that, besides being affected by WSV, individuals' between-session variabilities (BSVs) also vary because of state changes that affect their performance from day to day. It seems that both variability in performance from trial to trial during a session and variability in average performance from day to day are correlated, stable, individual difference characteristics that vary inversely with intelligence test performance. Methodological consequences of these results for interpretations of age-related cognitive changes, for variability between as well as within individuals, for individual differences in decision speed, and for circadian variability in performance are discussed.     

Age Affects Strategic But Not Spontaneous Recall in 35- and 46-Month-old Children

ABSTRACT

It is well documented that young children have difficulties with strategically remembering past events. Recent evidence on event memory in 35- and 46-month-old children suggests that strategic retrieval (yes/no questions) improves with age, whereas spontaneous retrieval is relatively unaffected by age. We here replicate and extend those findings (N = 124): First, a novel free (strategic) recall test was added to improve ecological validity. Second, the free recall procedure allowed us to make direct comparisons between spontaneous and free strategic recall relative to age. The free recall test revealed similar results in the standard yes/no questions (older children outperformed younger). The direct comparison between spontaneous and free recall revealed a reliable interaction between age and retrieval mode: While the children’s age did not affect spontaneous recall, the 46-month-olds outperformed the 35-month-olds on the free recall test. The results add to the accumulating evidence that spontaneous recall of events is an early developmental achievement.     

Validation of the Suicide Resilience Inventory‐25 with American and Chinese College Students

This study is the first to evaluate evidence for measurement invariance and the psychometric properties of the Suicide Resilience Inventory‐25 (SRI‐25; Osman et al., 2004 ) in college‐age samples in both the United States and China. We found strong support for full measurement invariance of the three‐factor structure of the SRI‐25 in the U.S. (113 men and 238 women) and Chinese (121 men and 205 women) samples. In addition, we found that the U.S. sample scored significantly higher than the Chinese sample on all the individual scale scores. Composite scale reliability estimates ranged from moderate (ρ = .83) to high (ρ = .93) across the groups. Although not an aim of the current study, we examined estimates of internal consistency of the SRI‐25 scales for men and women within each sample. Differential correlates of the SRI‐25 scales were explored further for each sample. These results provide support for the use of the SRI‐25 in U.S. and Chinese student samples.     

The Associations of Physical and Sexual Assault with Suicide Risk in Nonclinical Military and Undergraduate Samples

The associations of various forms of sexual and physical assault with a history of suicide attempts and recent suicide ideation were studied in two distinct samples: active duty military and undergraduate students. A total of 273 active duty Air Force personnel and 309 undergraduate students anonymously completed self‐report surveys of assault victimization, emotional distress, belongingness, recent suicide ideation, and previous suicide attempts. Among military personnel, rape, robbery, or violent assault was associated with a nonsignificant trend toward increased risk for suicide attempts, whereas physical abuse or battering as an adult was significantly associated with recent suicide ideation. Among undergraduates, unwanted sexual experiences as an adult and physical or sexual abuse as a child were significantly associated with increased risk for suicide attempt, but only unwanted experiences as an adult was significantly associated with increased risk for suicide ideation. Experiencing multiple forms of assault increased risk for suicide attempts and ideation in both groups. Results suggest that different types of assault contribute differentially to suicide risk in military versus undergraduate populations, but experiencing multiple types of assault is associated with increased risk in both groups.