Anxious personality and functional efficiency of the insular-opercular network: A graph-analytic approach to resting-state fMRI

The brain is an intricate network, not only structurally but also functionally. On the functional level, connectivity in the brain is organized in separable yet interacting networks that support information processing by maintaining a ready state, even in the absence of external stimulation. It has been hypothesized that an insular-opercular network underlies the processing of emotionally salient information and that individual differences in functional connectivity within this network correspond to individual differences in trait anxiety. Here, we tested this relationship by applying graph analysis to multiple regions of interests delineating the insular-opercular network to estimate the characteristic path length that quantifies the overall information exchange efficiency within a given network. We found that people scoring high on the anxiety-related temperament-dimension harm avoidance had decreased insular-opercular network efficiency in the resting state, as indicated by a higher characteristic path length. Furthermore, people scoring high on harm avoidance showed generally reduced functional connectivity between brain regions; the relationship between harm avoidance and insular-opercular network efficiency remained significant when controlling for mean connectivity within this network. No such results were found for other resting-state networks. The results provide insights into how personality is organized in the human brain and point toward clinically relevant endophenotypes for affective and mood disorders.     

Ecology and its Spiritual Significance: a Christian Reading

Journal of Indian Council of Philosophical Research - The present paper is based on the contention that there are two conceptions of the understanding of nature, nature as an object and nature as...     

The Construction of Issues: Pleading Theory and Practice, Relevance in Pragmatics, and the Confrontation Stage in the Pragma-Dialectical Theory of Argumentation

Legal theory and practice, particularly on the exchange of pleadings, are referred to as a means of examining current thinking in pragmatics on relevance. The rules of pleadings suggest that the concept of relevance as used in pragmatics is emptied of any meaning and that theories of argumentation have not sufficiently taken into account the preliminary construction which issues to be argued about require.     

Discriminating deterministic versus stochastic dynamics in neuronal activity

An approach to discriminating deterministic versus stochastic dynamics from neuronal data is presented. Direct tests for determinism are emphasized, as well as using time series with clear physical correlates measured from small ensembles of neurons. Surrogate data are used to provide null hypotheses that the dynamics in our data could be accounted for by linear stochastic systems. Algorithms are given in full, and the analysis of an experimental example is given.     

Establishing generalized verb-noun instruction-following skills in retarded children

A transfer of stimulus control procedure was used to establish generalized verb-noun instruction-following skills in two severely retarded boys. Each of 12 verbs was trained, in a multiple baseline order, to criterion with each of 12 nouns in the form of verb-noun verbal instructions. Throughout training, reinforced probes were conducted on both trained and untrained verb-noun combinations. As training progressed, both subjects began to respond correctly to untrained verb-noun instructions. Eventually, a verb needed to be trained in combination with only one noun before generalization occurred to the as-yet-untrained 11 verb-noun instructions involving that verb.