Seeing why they cannot see: Understanding the syndrome and causes of posterior cortical atrophy

Posterior cortical atrophy (PCA) is a syndrome defined by focal neurodegeneration of the parietal, occipital, and occipito‐temporal cortices and associated with progressive dysfunction of visual processing, praxis, numeracy and reading. The condition is most commonly caused by (and viewed as an atypical presentation of) Alzheimer's disease, although can also be caused by other degenerative diseases. The current paper examines the relationship of PCA to other degenerative syndromes, and considers what comparisons of these syndromes and disease phenotypes can tell us about underlying disease mechanisms. The focus then turns to neuropsychological investigations of the cognitive basis of symptoms which, although unusual in the broader context of a dementia clinic, are particularly characteristic of the PCA syndrome, before exploring implications for clinical management and patient and carer support.     

Pilot Testing and Preliminary Psychometric Validation of the Polish Translation of the EORTC INFO25 Questionnaire

The quality of information that oncological patients receive from health care professionals is an underestimated issue in Poland and Eastern European countries. There is lack of sufficient data on this subject. The European Organization for Research and Treatment of Cancer (EORTC) supplies a new tool for measuring the quality of information provided to cancer patients. The purpose of the study is the translation into Polish, pilot testing and preliminary validation of the EORTC information module (INFO25). Following the EORTC translation procedures, forward and back translations of the questionnaire were performed (English?→?Polish, Polish?→?English). The intermediate version of the INFO25 was pilot-tested together with the general questionnaire of quality of life (EORTC QLQ-C30). Reliability, validity and known-group comparison tests were performed. A total of 21 patients with different cancer diagnoses were recruited into the study (7 women and 14 men; mean age of 60,2 years, age range 25–73 years). Apart from filling out the INFO25, patients were interviewed about the difficulties with answering every questionnaire item. Patients' comments were analyzed and minor language changes were made to the initial translation. The internal consistency of the INFO25 showed a reliability of 0,78. The final version of the Polish translation of the INFO25 module was obtained and approved by the EORTC Quality of Life Department. It can now be used in clinical setting and for scientific purposes.     

Rasch analysis of a simplified Beck Depression Inventory

Depression is one of the most clinically relevant mood disorders, and many assessment instruments have been developed to measure it. Probably the most frequently used instrument is Beck’s Depression Inventory (BDI). The simplified BDI (BDI-S) is a more efficient version of the BDI that has been shown to be no less reliable or valid. As the BDI-S has not yet been subjected to rigorous tests of Item Response Theory, it is the aim of the present paper to conduct such an analysis using the Rasch model. This study subjected a simplified version of the BDI consisting of 20 items (BDI-S20) to a Rasch analysis in a sample of N = 5,035 participants. The scale, minus one misfitting item (BDI-S19), yielded a good approximation to Rasch assumptions. Moderate differential item functioning (DIF) was present. It is concluded that the BDI-S19 is an internally valid instrument for assessing depression, although some room for improvement exists.     

Differential Outcomes of Adolescents with Chronically Ill and Healthy Parents

Approximately 10% of children grow up with a parent who has been diagnosed with a chronic medical condition (CMC) and seem to be at risk for adjustment difficulties. We examined differences in behavioral, psychosocial and academic outcomes between 161 adolescents from 101 families with a chronically ill parent and 112 adolescents from 68 families with healthy parents, accounting for statistical dependence within siblings. Children between 10 and 20 years and their parents were visited at home and filled in questionnaires. Multilevel analyses showed that 20–60% of the variance in most adolescent outcomes was due to the family cluster effect, especially in internalizing problem behavior, caregiving variables and quality of parent attachment. Conversely, the variance in stress and coping variables and grade point average (GPA) was mainly due to individual characteristics. Adolescents with parents affected by CMC displayed more internalizing problems than the comparison group and scored higher on frequency of household chores, caregiving responsibilities, activity restrictions, isolation, daily hassles and stress. In addition, their grade point average was comparatively worse. No group differences in externalizing problems, coping skills and quality of parent attachment were found. In conclusion, the family cluster effect largely explains adolescent outcomes and should be accounted for. Adolescents with parents affected by CMC are subject to an increased risk for internalizing problems, adverse caregiving characteristics, daily hassles, stress and a low GPA. According to a family-centered approach, school counselors and health care practitioners should be alert to adjustment difficulties of children with a chronically ill parent.     

Answering the Ethical Question

Many philosophers have attempted to answer the ‘ethical question’: can the ethical value of an artwork ever contribute to its aesthetic value, and if so, how? In this paper, I consider a methodological question that arises out of this discussion: should attempts to address the ethical question use analytic tools found in contemporary philosophical literature, art criticism, or some combination of the two? I concur with arguments proposed elsewhere, which suggest that art criticism has an important role to play in addressing the ethical question. However, I argue that any fruitful attempt to answer the question must defend some particular way of understanding the ethical value of artworks, which suggests that we should address what I label the ‘art question’: what is the role and importance of art? This question, I suggest, is one with which philosophers can usefully engage. This division of labour offers a way forward in addressing this important issue.     

Epistemic closure and commutative, nonassociative residuated structures

K-axiom-based epistemic closure for explicit knowledge is rejected for even the most trivial cases of deductive inferential reasoning on account of the fact that the closure axiom does not extend beyond a raw consequence relation. The recognition that deductive inference concerns interaction as much as it concerns consequence allows for perspectives from logics of multi-agent information flow to be refocused onto mono-agent deductive reasoning. Instead of modeling the information flow between different agents in a communicative or announcement setting, we model the information flow between different states of a single agent as that agent reasons deductively. The resource management of the database of agent states for the deductive reasoning fragment in question is covered by the residuated structure that encodes the nonassociative Lambek Calculus with permutation, bottom, and identity: NLP ₀₁ .     

Clarifying body-image disturbance: analysis of a multidimensional model using structural modeling

A multidimensional model of body-image disturbance was tested. The model incorporated the concepts of body-size distortion, preference for thinness, body dissatisfaction, and fear of fatness as predictors of restrictive eating. The LISREL 7 program was used to perform a structural modeling analysis of the theoretical model. A total of 175 women participated in the study (54 eating-disordered patients and 121 undergraduate students). The results supported the hypothesized four-dimensional model relative to alternative one-, two-, and three-dimensional models. Body dissatisfaction appeared to be directly affected by both body-size distortion and preference for thinness. Fear of fatness was found to be the best predictor of restrictive eating. The results appeared consistent across the clinical and nonclinical samples. These data may help resolve many of the current controversies in the body-image literature. The results also suggested the need to develop more sound assessment instruments for fear of fatness.     

The Construction of Issues: Pleading Theory and Practice, Relevance in Pragmatics, and the Confrontation Stage in the Pragma-Dialectical Theory of Argumentation

Legal theory and practice, particularly on the exchange of pleadings, are referred to as a means of examining current thinking in pragmatics on relevance. The rules of pleadings suggest that the concept of relevance as used in pragmatics is emptied of any meaning and that theories of argumentation have not sufficiently taken into account the preliminary construction which issues to be argued about require.