Ethics, biotechnology, and global health: the development of vaccines in transgenic plants

As compared with conventional vaccine production systems, plant-made vaccines (PMVs) are said to enjoy a range of advantages including cost of production and ease of storage for distribution in developing countries. In this article, we introduce the science of PMV production, and address ethical issues associated with development and clinical testing of PMVs within three interrelated domains: PMVs as transgenic plants; PMVs as clinical research materials; and PMVs as agents of global health. We present three conclusions: first, while many of the ethical issues raised by PMVs are familiar, PMVs add a new dimension to old issues, and raise some novel issues for ethicists and policy-makers; secondly, it is premature to promise broad applicability of PMVs across the developing world without having demonstrated their feasibility; thirdly, in particular, proponents of PMVs as a solution to global health problems must, as a condition of the ethical conduct of their research, define the commercial feasibility of PMVs for distribution in the developing world.     

Associations among early abuse, dissociation, and psychopathy in an offender sample

Theorists have postulated that some variants of psychopathy result from childhood abuse and neglect. Dissociative symptoms are also thought to arise from abuse. To date, the conjoint associations among abuse, dissociation, and psychopathy have not been examined systematically. Some have hypothesized that abuse relates primarily to the affective symptoms of psychopathy, with dissociative experiences mediating this relationship. Others have suggested that abuse more directly affects the impulsive lifestyle features of psychopathy. The authors used structural equation modeling to examine these hypotheses in a sample of 615 male offenders who had completed a retrospective self-report measure of childhood abuse, the Dissociative Experiences Scale, and R. D. Hare's (2003) Psychopathy Checklist--Revised. Abuse exerted no direct or indirect effect on the core interpersonal and affective features of psychopathy but was directly related to the facet of psychopathy associated with an impulsive and irresponsible lifestyle. Implications for psychopathy subtypes are discussed.     

Manipulating inattentional blindness within and across sensory modalities

People often fail to consciously perceive visual events that are outside the focus of attention, a phenomenon referred to as inattentional blindness or IB (i.e., Mack & Rock, 1998). Here, we investigated IB for words within and across sensory modalities (visually and auditorily) in order to assess whether dividing attention across different senses has the same consequences as dividing attention within an individual sensory modality. Participants were asked to monitor a rapid stream of pictures or sounds presented concurrently with task-irrelevant words (spoken or written). A word recognition test was used to measure the processing for unattended words compared to word recognition levels after explicitly monitoring the word stream. We were able to produce high levels of IB for visually and auditorily presented words under unimodal conditions (Experiment 1) as well as under crossmodal conditions (Experiment 2). A further manipulation revealed, however, that IB is less prevalent when attention is divided across modalities than within the same modality (Experiment 3). These findings are explained in terms of the attentional load hypothesis and suggest that, contrary to some claims, attention resources are to a certain extent shared across sensory modalities.     

Group treatment for trichotillomania: behavior therapy versus supportive therapy

In this randomized controlled trial, group behavior therapy (BT; n = 12) was compared to group supportive therapy (ST; n = 12) in the treatment of trichotillomania (TTM). Both treatments were also compared to a naturally occurring waiting period, the time period that participants waited for groups to form. Participants completing group BT experienced significantly greater decreases in self-reported hair-pulling symptoms and clinician-rated hair loss severity than did those in group ST. Decreases were significantly greater after treatment than after the naturalistic waiting period. In addition, a significantly higher percentage of those in the BT than ST condition were rated as much improved or very much improved on the Clinical Global Impression scale at posttreatment. However, despite substantial symptom improvement, TTM severity remained problematic at posttreatment. Specifically, few participants in either treatment met criteria for clinically significant change at posttreatment. In addition, relapse of symptoms occurred over the 6-month follow-up period. Results provided partial support for the short-term efficacy of group BT. However, the group format may not maximize the efficacy of BT for TTM. Thus, it is recommended that future BT research test either individual therapy or a combination of group and individual formats for TTM.     

Pragmatism, Naturalism, and Phenomenology

Pragmatism’s naturalism is inconsistent with the phenomenological tradition’s anti-naturalism. This poses a problem for the methodological consistency of phenomenological work in the pragmatist tradition. Solutions such as phenomenologizing naturalism or naturalizing phenomenology have been proposed, but they fail. As a consequence, pragmatists and other naturalists must answer the phenomenological tradition’s criticisms of naturalism.     

The Frame Problem and Theories of Belief

The frame problem is the problem of how we selectively apply relevant knowledge to particular situations in order to generate practical solutions. Some philosophers have thought that the frame problem can be used to rule out, or argue in favor of, a particular theory of belief states. But this is a mistake. Sentential theories of belief are no better or worse off with respect to the frame problem than are alternative theories of belief, most notably, the “map” theory of belief.     

Visual illusions affect planning but not control

Much debate has arisen over how to account for the pattern of effects of visual illusions on action - that is, the findings that illusions affect actions in some circumstances but not others. I propose that this pattern can best be explained by postulating that visual illusions affect the planning of actions but do not affect the on-line control of actions. Strong evidence for this viewpoint comes from recent studies that show 'dynamic illusion effects': a large illusion effect early in a movement, but a decreasing effect as the hand approaches the target. These findings pose difficulties for other models of illusion effects on action.