Metabolic and endocrine disturbances in psychiatric disorders: a multidisciplinary approach to appropriate atypical antipsychotic utilization

Patients with psychiatric disorders have an increased rate of cardiovascular morbidity and mortality compared with the general population. Metabolic issues such as weight gain, dyslipidemia, diabetes mellitus, diabetic ketoacidosis,and pancreatitis have been reported with the use of antipsychotic agents. Although atypical antipsychotics have not been linked directly to the development of metabolic syndrome, these medications have been shown to increase risk factors that can lead to metabolic and endocrine disturbances. Therefore, clinicians should provide ongoing monitoring for patients who are being treated for psychiatric disorders with these agents. According to the 2004 Consensus Report on Antipsychotics, screening measures should include baseline and follow-up monitoring of personal/family histories, weight (body mass index), waist circumference, blood pressure, fasting plasma glucose, and fasting lipid profile.     

A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorder

Mixed amphetamine salts extended release (MAS XR; Adderall XR) and atomoxetine (Strattera) were compared in children 6 to 12 years old with attention deficit/hyperactivity disorder (ADHD) combined or hyperactive/impulsive type in a randomized, double-blind, multicenter, parallel-group, forced-dose-escalation laboratory school study. Primary efficacy measure was the SKAMP (Swanson, Kotkin, Agler, M-Flynn, and Pelham) behavioral rating scale. Changes in mean SKAMP deportment scores from baseline were significantly greater for MAS XR (n = 102) than for atomoxetine (n = 101) overall (-0.56 and -0.13, respectively; p < .0001) and at each week (p < .001). Adverse events were similar for both treatment groups. The extended time course of action and greater therapeutic efficacy of MAS XR suggests that it is more effective than atomoxetine in children with ADHD.     

A neural network model of foraging decisions made under predation risk

This article develops the cognitive—emotional forager (CEF) model, a novel application of a neural network to dynamical processes in foraging behavior. The CEF is based on a neural network known as the gated dipole, introduced by Grossberg, which is capable of representing short-term affective reactions in a manner similar to Solomon and Corbit’s (1974) opponent process theory. The model incorporates a trade-off between approach toward food and avoidance of predation under varying levels of motivation induced by hunger. The results of simulations in a simple patch selection paradigm, using a lifetime fitness criterion for comparison, indicate that the CEF model is capable of nearly optimal foraging and outperforms a run-of-luck rule-of-thumb model. Models such as the one presented here can illuminate the underlying cognitive and motivational components of animal decision making.     

Development of perceptual completion in infancy

Perceptual completion consists of bridging the gaps imposed by occlusion, such as perceiving the unity of center-occluded objects. It is unknown at present what developmental mechanisms underlie the emergence of functional perceptual completion in infancy. One current debate centers on the role of visible surface motion. According to a core-principles account, perceptual completion emerges simultaneously with the onset of motion discrimination, the sole determinant of unity percepts in infants. According to a contrasting constructivist account, motion discrimination is but one of several independent inputs to perceptual completion. In the present study, 2-month-old infants were tested for both unity perception and motion discrimination in partial-occlusion displays. Motion discrimination obtained under all conditions, even under circumstances in which infants were unable to perceive completion. Four-month-olds showed marked improvements in perceptual completion, most likely because of improvements in information integration. Taken together, these findings support a constructivist view of early perceptual and cognitive development.     

How dogs navigate to catch frisbees

Using micro-video cameras attached to the heads of 2 dogs, we examined their optical behavior while catching Frisbees. Our findings reveal that dogs use the same viewer-based navigational heuristics previously found with baseball players (i.e., maintaining the target along a linear optical trajectory, LOT, with optical speed constancy). On trials in which the Frisbee dramatically changed direction, the dog maintained an LOT with speed constancy until it apparently could no longer do so and then simply established a new LOT and optical speed until interception. This work demonstrates the use of simple control mechanisms that utilize invariant geometric properties to accomplish interceptive tasks. It confirms a common interception strategy that extends both across species and to complex target trajectories.     

The persistence of underpowered studies in psychological research: causes, consequences, and remedies

Underpowered studies persist in the psychological literature. This article examines reasons for their persistence and the effects on efforts to create a cumulative science. The "curse of multiplicities" plays a central role in the presentation. Most psychologists realize that testing multiple hypotheses in a single study affects the Type I error rate, but corresponding implications for power have largely been ignored. The presence of multiple hypothesis tests leads to 3 different conceptualizations of power. Implications of these 3 conceptualizations are discussed from the perspective of the individual researcher and from the perspective of developing a coherent literature. Supplementing significance tests with effect size measures and confidence intervals is shown to address some but not necessarily all problems associated with multiple testing.     

Asians on the edge: the reciprocity of allied behavior

The discussion of racial and ethnic minority issues has traditionally been a Black-White discussion. As such, American Indians, Latinos, and Asians have been left out of this discussion. Such exclusion does not make scientific sense, as it makes conclusions about race relations less generalizable. It also comes with a cost, as the excluded groups are often asked to give up their respective ethnicities to join the discussion. The present article, discusses some of these scientific and social losses and suggests that prominent African American and White leaders serve as allies for the inclusion of all groups in the discussion of race relations, focusing particularly on the Asian experience. Such allies must come not only from academicians but also from community activists and those in power positions in the media.     

Selective sex differences in declarative memory

Sex invariance of a six-factor, higher order model of declarative memory (two second-order factors: episodic and semantic memory; and four first-order factors: recall, recognition, fluency, and knowledge) was established for 1,796 participants (35-85 years). Metric invariance of first- and second-order factor loadings across sex was demonstrated. At the second-order level, a female advantage was observed for both episodic and semantic memory. At the first-order level, sex differences in episodic memory were apparent for both recall and recognition, whereas the differences in semantic memory were driven by a female superiority in fluency. Additional tests of sex differences in three age groups (35-50, 55-65, and 70-85 years of age) indicated that the female superiority in declarative memory diminished with advancing age. The factor-specific sex differences are discussed in relation to sex differences in hippocampal function.