Ethical and practical considerations in managing incidental findings in functional magnetic resonance imaging

Functional magnetic resonance imaging has emerged as a powerful tool for mapping the neurologic underpinnings of sensory, motor and cognitive function. Much of this evolution carries assumptions about the subject population under study and, in particular, the neurologic status of subjects entered into studies either as healthy controls or as belonging to a specific disease group. Recent reports of incidental MRI abnormalities in normal volunteers for fMRI studies have brought to attention a variety of practical challenges and ethical dilemmas for researchers, many of whom are not physicians and most of whom have no formal radiological training. We propose a minimum standard for consenting subjects in fMRI protocols, and consider strategies over the longer term that call for expert physician participation, archiving of incidental findings including false positives, and the adoption of guidelines for handling variation in neural activations or performance that appear outside expected norms.     

Spatial stimulus cue information supplying auditory saltation

Auditory saltation is a misperception of the spatial location of repetitive, transient stimuli. It arises when clicks at one location are followed in perfect temporal cadence by identical clicks at a second location. This report describes two psychophysical experiments designed to examine the sensitivity of auditory saltation to different stimulus cues for auditory spatial perception. Experiment 1 was a dichotic study in which six different six-click train stimuli were used to generate the saltation effect. Clicks lateralised by using interaural time differences and clicks lateralised by using interaural level differences produced equivalent saltation effects, confirming an earlier finding. Switching the stimulus cue from an interaural time difference to an interaural level difference (or the reverse) in mid train was inconsequential to the saltation illusion. Experiment 2 was a free-field study in which subjects rated the illusory motion generated by clicks emitted from two sound sources symmetrically disposed around the interaural axis, ie on the same cone of confusion in the auditory hemifield opposite one ear. Stimuli in such positions produce spatial location judgments that are based more heavily on monaural spectral information than on binaural computations. The free-field stimuli produced robust saltation. The data from both experiments are consistent with the view that auditory saltation can emerge from spatial processing, irrespective of the stimulus cue information used to determine click laterality or location.     

Change in cognitive functioning associated with apoE genotype in a community sample of older adults

The influence of a genetic risk factor, apolipoprotein E (apoE) epsilon4 variant, was assessed in older adults aged 70 to 94 on 3 occasions over 7 years. The results of latent growth curve analyses are reported for individuals genotyped for apoE at the 2nd measurement occasion (n = 601) and for a subsample of individuals without probable or definite dementia during the 1st or 2nd occasion (n = 434). ApoE-epsilon4 status was a significant predictor of level and change in memory performance and change in speed performance in the full sample, and of initial level and change in memory performance in the nondemented subsample. These results support previous findings that apoE-epsilon4 is associated with accelerated memory deterioration in individuals without clinical dementia.     

The use of reliable digits to detect malingering in a criminal forensic pretrial population

The present research is a cross-validation of previous investigation by Greiffenstein, Baker; and Gola; Greiffenstein, Gola, and Baker; and Meyers and Volbrecht on the reliable digits (RELD) method of detecting suspected malingering on the Wechsler Adult Intelligence Scale-Revised (WAIS-R). The results support the use of the RELD method on a criminalforensic pretrial population (N = 187). Sensitivities, specificities, and incremental hit ratesfor two cut levels of the RELD method, Minnesota Multiphasic Personality Inventory-2 (MMPI-2) Infrequency and the Personality Assessment Inventory Negative Impression Scales, as well as multiple combined cut scores, were comparable to those observed in previous studies that used neuropsychologically evaluated participants. The selection of which cut score or combination of cut scores is appropriate on the RELD method is also discussed.     

An examination of organizational and team commitment in a self-directed team environment

A model hypothesizing differential relationships among predictor variables and individual commitment to the organization and work team was tested. Data from 485 members of sewing teams supported the existence of differential relationships between predictors and organizational and team commitment. In particular, intersender conflict and satisfaction with coworkers were more strongly related to team commitment than to organizational commitment. Resource-related conflict and satisfaction with supervision were more strongly related to organizational commitment than to team commitment. Perceived task interdependence was strongly related to both commitment foci. Contrary to prediction, the relationships between perceived task interdependence and the 2 commitment foci were not significantly different. Relationships with antecedent variables help explain how differential levels of commitment to the 2 foci may be formed. Indirect effects of exogenous variables are reported.     

Parent coping styles and schizophrenic patient behavior as predictors of expressed emotion

Several studies have examined relationships between levels of expressed emotion in relatives of individuals with schizophrenia and the coping strategies these relatives employ. In an attempt to elucidate these relationships, 44 parents were assessed using the Camberwell Family Interview and the Strategic Approach to Coping Scale. Associations between these measures were examined. Additionally, interactions between parent coping style and patient aggression were assessed with respect to expressed emotion. The results indicate that scores on the coping scale generally were not directly related to levels of expressed emotion. However, an interaction was found between parent coping style and patient behavior which predicted level of expressed emotion. This finding supports the idea that research into the variables underlying expressed emotion should include the assessment of both parent and patient characteristics and examine the interactions between these variables.     

Childhood Gender Nonconformity and Body Dissatisfaction in Gay and Heterosexual Men

Although researchers have long hypothesized a relation between gender role orientation (i.e., masculinity and femininity) and body dissatisfaction, findings have been inconsistent. The current study employed a measure of recalled childhood gender nonconformity to examine gender role behaviors in association with body dissatisfaction among an ethnically diverse (76% Caucasian, 2% African American, 8% Asian, and 16.4% Hispanic American) group of predominantly college-aged males of both homosexual (n = 129) and heterosexual (n = 52) orientation. Consistent with past research, gay males reported more body dissatisfaction and recalled more childhood gender atypical behaviors (e.g., disliking athletics, playing with dolls). Group differences in body dissatisfaction, however, disappeared when childhood gender nonconformity was statistically controlled, suggesting childhood atypical gender role behavior may place males at greater risk for adult body dissatisfaction. A within-group analysis also found that a high feminine subtype of gay males had greater body dissatisfaction than less feminine subtypes had. Results support the assertion that gender role behaviors may contribute to body dissatisfaction among gay males.     

Reaction of mock jurors to testimony of a court appointed expert

A study was conducted to assess the impact of court appointed experts on the judgments of mock jurors. A civil proceeding was adopted for the experiment. Mock jurors heard testimony about a plaintiff's injury in an automobile accident. In some conditions, medical testimony for the plaintiff and defendant was provided by experts hired by each side. In other conditions, a medical expert appointed by the court testified in addition to the two adversarial experts. In one of these conditions, the court expert sided with the plaintiff; in another, the expert sided with the defendant. The plaintiff in the case was always an individual. The defendant was sometimes a corporation and sometimes an individual. The results showed that mock jurors sided with the court appointed expert in every condition except when the expert favored a corporate defendant. The results were discussed in terms of heuristic processing of persuasive information.