Short-term sentence recall: evidence for the contribution of acoustic-sensory information

To demonstrate that short-term sentence recall is based on conceptual and lexico-semantic information, Potter and Lombardi [J. Memory Lang. 29 (1990) 633] conducted a series of experiments using the intrusion paradigm, which combines short-term sentence recall and lexical priming. In the present paper, we employed the intrusion paradigm to demonstrate that acoustic-sensory information is involved in sentence regeneration as well. For this purpose, we presented sentences visually for silent reading (conceptual and phonological information) and reading aloud (conceptual, phonological, and--in addition--acoustic-sensory information). We demonstrated that less intrusions appeared in the reading aloud condition. This effect supports the assumption that, if available, acoustic-sensory information contributes to the regeneration process.     

Parents’ Planning for Physical Activity for their Pre-School Aged Children: The Role of Psycho-Social Mediators and Moderators

Despite the childhood benefits gained from engaging in adequate physical activity, Australian preschool-aged children are reported to spend little time being physically active. Parental planning is important to engaging preschool-aged children in physical activity. Behavioral barriers, normative support, and self-efficacy have been identified as key determinants of parental decision making. However, the interplay among these factors is not well understood. The aim of this study was to examine the role of these psycho-social variables on parents’ planning and behavior for their preschool-aged children’s physical activity. A survey at two points in time was conducted in 208 Australian parents (n?=?139 mothers, M _age?=?36.43 years, SD?=?5.04; n?=?69 fathers, M _age?=?36.33 years, SD?=?6.5) of children aged between 2 and 5 years. A conditional process analysis was conducted that integrates mediation and moderation analyses. The results showed that planning and behavioral barriers predicted behavior, with a moderation effect also identified; more planning helped compensate for barriers. Normative support predicted both planning and behavior. In addition, an interaction between normative support and self-efficacy emerged. Parents with high self-efficacy engaged in high levels of planning, independent of normative support. Low self-efficacy with low normative support resulted in the lowest amount of planning; however, in the absence of normative support a high level of self-efficacy could compensate for it. Current findings provide avenues for future research to develop interventions to test the efficacy of these mechanisms in promoting parents’ ability to ensure preschool-aged children are active.     

Differentiating anxiety and depression: the State-Trait Anxiety-Depression Inventory

ABSTRACT

The differentiation of trait anxiety and depression in nonclinical and clinical populations is addressed. Following the tripartite model, it is assumed that anxiety and depression share a large portion of negative affectivity (NA), but differ with respect to bodily hyperarousal (specific to anxiety) and anhedonia (lack of positive affect; specific to depression). In contrast to the tripartite model, NA is subdivided into worry (characteristic for anxiety) and dysthymia (characteristic for depression), which leads to a four-variable model of anxiety and depression encompassing emotionality, worry, dysthymia, and anhedonia. Item-level confirmatory factor analyses and latent class cluster analysis based on a large nation-wide representative German sample (N?=?3150) substantiate the construct validity of the model. Further evidence concerning convergent and discriminant validity with respect to related constructs is obtained in two smaller nonclinical and clinical samples. Factors influencing the association between components of anxiety and depression are discussed.     

Sufficiency and Necessity Assumptions in Causal Structure Induction

Research on human causal induction has shown that people have general prior assumptions about causal strength and about how causes interact with the background. We propose that these prior assumptions about the parameters of causal systems do not only manifest themselves in estimations of causal strength or the selection of causes but also when deciding between alternative causal structures. In three experiments, we requested subjects to choose which of two observable variables was the cause and which the effect. We found strong evidence that learners have interindividually variable but intraindividually stable priors about causal parameters that express a preference for causal determinism (sufficiency or necessity; Experiment 1). These priors predict which structure subjects preferentially select. The priors can be manipulated experimentally (Experiment 2) and appear to be domain‐general (Experiment 3). Heuristic strategies of structure induction are suggested that can be viewed as simplified implementations of the priors.     

Early antecedents of spouse abuse

Males taken into police custody for reported spouse abuse (n = 19) and a matched control group (n = 19) were asked to describe the drinking habits of their parents and the extent of intra-family violence witnessed by them as children. The retrospective data were compared to the participant's own present alcohol use and aggressiveness (CTS). Excessive paternal drinking and intra-family violence were recalled significantly more often by the spouse abusers than by the controls. A latent structure model suggested that the accumulated violence history was less well predicted by either paternal violence or present aggressiveness than by the direct and indirect effects related to drinking. Context-specific social learning could explain why the parental drunken violence behavior pattern witnessed by the child was repeated by the adult spouse abuser. Aggr. Behav. 23:239–243, 1997. © 1997 Wiley-Liss, Inc.     

Manualisierte psycho- dynamisch-interaktionelle Gruppentherapie

20–40% of the patients in general practices, as well as in different departments in hospitals, suffer from somatoform diseases. 70% of these patients have pain as their main complaint. The present treatment manual is the first disease-specific, psychodynamically oriented group-treatment for these patients. Compared to other psychodynamic treatment settings this therapy is a short and cost-effective approach to treat these patients. It is based on a so-called psychodynamic-interactional group psychotherapy and focuses on disease-specific parts of the problem, as well as on psychic and interpersonal problems resulting from adverse childhood experiences. Over a period of six months 7 to 9 patients are treated in 40 group therapy sessions. Two weekly meetings are held during the first four months and one weekly session is held during the last two months. The concept contains psycho-educational elements, the discussion and formulation of individual treatment goals as well as work with a psychodynamic and relationship- oriented treatment focus. The efficacy of this concept is planned to be evaluated in a randomised, controlled clinical trial, including two treatment conditions and one control condition. One of the two treatment conditions is, beneath the concept already discussed, a cognitive behavioural group therapy.     

Behavioral deficits and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampus

The NMDA receptor (NMDAR) subunit GluN1 is an obligatory component of NMDARs without a known functional homolog and is expressed in almost every neuronal cell type. The NMDAR system is a coincidence detector with critical roles in spatial learning and synaptic plasticity. Its coincidence detection property is crucial for the induction of hippocampal long-term potentiation (LTP). We have generated a mutant mouse model expressing a hypomorph of the Grin1^N598R allele, which leads to a minority (about 10%) of coincidence detection-impaired NMDARs. Surprisingly, these animals revealed specific functional changes in the dentate gyrus (DG) of the hippocampal formation. Early LTP was expressed normally in area CA1 in vivo, but was completely suppressed at perforant path-granule cell synapses in the DG. In addition, there was a pronounced reduction in the amplitude of the evoked population spike in the DG. These specific changes were accompanied by behavioral impairments in spatial recognition, spatial learning, reversal learning, and retention. Our data show that minor changes in GluN1-dependent NMDAR physiology can cause dramatic consequences in synaptic signaling in a subregion-specific fashion despite the nonredundant nature of the GluN1 gene and its global expression.According to Hebb''s postulate, neurons require a molecular mechanism to detect synchronous activity in order to change the strength of synaptic connectivity (Hebb 1949). NMDA receptors (NMDARs) are molecular coincidence detectors, and selective NMDAR antagonists block the induction of long-term potentiation (LTP) in both the dentate gyrus (DG) and CA1 regions of the hippocampus (Bliss and Collingridge 1993; Martin et al. 2000). NMDARs have been long known for their role in spatial learning, but more recently have been implicated in other forms of cognitive function and dysfunction (Gruart et al. 2006; Whitlock et al. 2006; Castner and Williams 2007; Kristiansen et al. 2007; Wilson and Linster 2008).Neuronal NMDARs are hetero-tetrameric ligand-gated ion channels typically comprised of two types of subunits. Two copies of the mandatory GluN1 subunit (or NR1 subunit [Collingridge et al. 2009] encoded by Grin1) are associated with two copies from the GluN2 family, GluN2A–D (or NR2A–D). The GluN1 subunit is expressed ubiquitously both spatially and temporally throughout the developing and adult brain. Global knockout mice models of the GluN1 subunit are postnatally lethal within hours after birth (Forrest et al. 1994; Li et al. 1994), and cell-specific GluN1 mice knockouts (Tsien et al. 1996; Nakazawa et al. 2002; McHugh et al. 2007; Niewoehner et al. 2007) have provided insights on how specific synapses and regional neuronal networks are dependent on NMDAR function.The early postnatal lethality of the global GluN1 knockout is in contrast to the null mutants of the four AMPA receptor genes and other major synaptic proteins, such as αCaMKII (Silva et al. 1992a,b; Jia et al. 1996; Zamanillo et al. 1999; Meng et al. 2003). This can be at least partially explained by the absence of any close GluN1 homologs, which could functionally compensate for the absence of the GluN1 subunit. Recombinant expression studies defined the GluN1 subunit as a mandatory component of NMDARs. This constellation provides a specific opportunity to test whether different local neuronal subnetworks are affected differentially by mutant Grin1 alleles associated with subtle alterations of the functional properties of NMDARs.GluN1 subunits with the N598R point mutation (GluN1^R) yield functional NMDARs that are Mg²⁺ insensitive and Ca²⁺ impermeable (Burnashev et al. 1992; Mori et al. 1992). The Grin1^N598R allele that codes for GluN1^R subunits is a gain-of-function mutation that is dominant lethal, even in heterozygous and hemizygous lines (Single et al. 2000; Rudhard et al. 2003). NMDARs with GluN1^R subunits do not act as coincidence detectors and, interestingly, mice expressing exclusively the GluN1^R allele lack whisker-related pattern formation in the neonate brainstem (Rudhard et al. 2003).To investigate the functional importance of GluN1 subunits with the N598R point mutation, we took advantage of the generation of a variant mutant line of mice (GluN1^Rneo/+) expressing a minority (around 10%) of these mutant NMDARs. Even though the majority of the NMDARs are normal, all neurons expressing NMDARs will contain a subset of receptors carrying this mutation.Therefore, this mouse model is an ideal candidate to study the impact of subtle alterations of NMDAR function on different neuronal networks, such as those comprising the hippocampal formation.Studies examining region-specific targeted disruption of GluN1 expression in subregions of the hippocampus have revealed subtle yet important contributions of this NMDAR subunit in synaptic plasticity and spatial learning and memory. CA1-restricted knockout of GluN1 expression in the hippocampus caused impaired spatial learning and memory as well as reduced CA1-LTP (Tsien et al. 1996). In the case of the disruption of GluN1 expression in the DG region of the hippocampus, more subtle behavioral impairments were apparent, including the inability to discriminate between two similar contexts (pattern separation) and deficits in spatial working memory despite normal LTP in the CA1 region (McHugh et al. 2007; Niewoehner et al. 2007).Our GluN1^Rneo/+ mice differ from the region-specific GluN1 mutant mice in that they express the mutant hypomorph at the same level in different subregions of the hippocampus. Interestingly, we found that this allele leads to substantial differences in short- and long-term plasticity between area CA1 and the DG of the hippocampus. The specific impairment in the DG was accompanied by impaired spatial recognition, spatial learning, reversal learning, and retention. Our data establish the possibility of a circuit-specific phenotype caused by a mutant variant of a globally expressed major nonredundant synaptic protein.     

Religious Values in Clinical Practice are Here to Stay

Research to date has shown that health professionals often practice according to personal values, including values based on faith, and that these values impact medicine in multiple ways. While some influence of personal values are inevitable, awareness of values is important so as to sustain beneficial practice without conflicting with the values of the patient. Detecting when own personal values, whether based on a theistic or atheistic worldview, are at work, is a daily challenge in clinical practice. Simultaneously ethical guidelines of tone-setting medical associations like American Medical Association, the British General Medical Council and Australian Medical Association have been updated to encompass physicians’ right to practice medicine in accord with deeply held beliefs. Framed by this context, we discuss the concept of value-neutrality and value-based medical practice of physicians from both a cultural and ethical perspective, and reach the conclusion that the concept of a completely value-neutral physician, free from influence of personal values and filtering out value-laden information when talking to patients, is simply an unrealistic ideal in light of existing evidence. Still we have no reason to suspect that personal values, whether religious, spiritual, atheistic or agnostic, should hinder physicians from delivering professional and patient-centered care.