Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

CAUSATION,DISPOSITIONS, AND PHYSICAL OCCASIONALISM

Even though theistic philosophers and scientists agree that God created, sustains, and providentially governs the physical universe and even though much has been published in general regarding divine action, what is needed is a fine‐grained, conceptually coherent account of divine action, causation, dispositions, and laws of nature consistent with divine aseity, satisfying the widely recognized adequacy conditions for any account of dispositions.¹ Such an account would be a basic part of a more comprehensive theory of divine action in relation to the fundamental concepts of science and of mathematics. Our aim in this article is simply to present such a theory.     

Young,unassimilated hispanic offenders: Absolutist vs. relativist cultural assumptions

California State Law §288(a) defines any sexual contact between a person 18 or older with someone under the age of 14 as illegal and punishable by incarceration. Data from the State Department of Justice shows that Young, Unassimilated Hispanic Offenders (YUHO) are arrested for these crimes at rates disproportionately greater than their numbers in the population. Through a review of the pertinent literature and clinical archives, we argue that YUHOs have been acculturated into a sexual morality that violates legally codified American sexual standards. While their sexual behavior is deemed morally deviant and illegal in the United States, this same behavior is not considered morally deviant or illegal within their internalized, home culture. This contrasts with the typical §288(a) offender who is motivated by a sexual perversion. Should the criminal justice system regard YUHOs differently from typical §288(a) offenders? “relativists” suggest that cultural considerations should be taken in the adjudication of these cases. Our preliminary work is to inform and articulate this debate at the crossroads of psychology, anthropology and criminal justice, without advocating either of the above perspectives. We suggest that legislatures did not anticipate the population of YUHO sexual offenders when these laws were written, and argue that YUHOs differ significantly from the typical pedophile for which these statutes were intended.     

Differential Effects of Strategic Planning on Community Change in Two Urban Neighborhood Coalitions

Community coalitions represent a promising approach for addressing the interrelated and multiply- determined issues affecting urban neighborhoods of concentrated poverty. The literature suggests a number of community processes that may affect coalition efforts to change and improve communities. This study uses an interrupted time-series design to examine the effects of a strategic planning intervention on community change in two urban neighborhoods in the Kansas City metropolitan area. Results showed that strategic planning was associated with increased rates of community change in the two urban neighborhood coalitions. Under appropriate conditions, such as the presence of consistent leadership, strategic planning may be a particularly effective mechanism for stimulating community change and addressing locally-determined goals in urban neighborhoods.     

Experimental analysis of preschool playmate preferences as a function of smiles and sex

Differential emotions theory (DET) (The face of emotion. Appleton‐Century‐Crofts: East Norwalk, CT, 1971) posits that the smile functions in part to communicate and/or reflect social affiliation and plays an important role in children's social development. While children's positive emotion expressions have received attention from peer relations researchers in observational studies and within correlational designs, there is almost no experimental evidence for the impact of the smile. Building on existing studies, the present study examined DET predictions within an experimental design. More specifically, we examined the impact smiles have on lower‐income preschool children's nominations for preferred playmates. Both boys and girls tended to nominate unfamiliar playmates who smiled. Additionally, some evidence suggested that preference for smiling playmates seemed more critical to girls' than boys' social functioning. Unlike among boys, teachers rated girls who exhibited a greater preference for smiling playmates as higher in social competence. Copyright © 2008 John Wiley & Sons, Ltd.     

Using Public Service Announcements to Change Behavior: No More Money and Oil Down the Drain1

Radio and television offer promising media for addressing large‐scale social problems. Unfortunately, very few mass‐media messages have utilized social psychological theories of persuasion and influence. This article summarizes 2 studies that evaluated the effectiveness of a state‐sponsored public service announcement aimed at reducing improper disposal of used motor oil among do‐it‐yourself oil changers. Study 1 was a field experiment with 120 oil changers in San Diego County. Inertial resistance and low perceived behavioral control were identified as obstacles to proper disposal. In Study 2 , we used the disrupt‐then‐reframe technique to successfully overcome these obstacles and promote proper disposal of used oil. The results underscore the usefulness of empirically validated persuasion techniques in changing behavior via mass media.     

Superior temporal activation in response to dynamic audio-visual emotional cues

Perception of emotion is critical for successful social interaction, yet the neural mechanisms underlying the perception of dynamic, audio-visual emotional cues are poorly understood. Evidence from language and sensory paradigms suggests that the superior temporal sulcus and gyrus (STS/STG) play a key role in the integration of auditory and visual cues. Emotion perception research has focused on static facial cues; however, dynamic audio-visual (AV) cues mimic real-world social cues more accurately than static and/or unimodal stimuli. Novel dynamic AV stimuli were presented using a block design in two fMRI studies, comparing bimodal stimuli to unimodal conditions, and emotional to neutral stimuli. Results suggest that the bilateral superior temporal region plays distinct roles in the perception of emotion and in the integration of auditory and visual cues. Given the greater ecological validity of the stimuli developed for this study, this paradigm may be helpful in elucidating the deficits in emotion perception experienced by clinical populations.     

A longitudinal study of the performance of hypertensive and normotensive subjects on the Wechsler Adult Intelligence Scale

Performance on the Wechsler Adult Intelligence Scale was followed over two 5- to 6-year intervals for essential hypertensive Ss (EH; n = 22) free from medical complications and for normotensive Ss (N; n = 20). EH were treated with adrenergic beta-blocking drugs, diuretics, or both. Mean age was 46 years (SD = 12.6 years), initially (Time 1). Results were unaltered by adjustment for initial age. N improved modestly on the Verbal scale, from Time 1 to Time 2 only. EH neither improved nor declined on the Verbal scale. Scores remained unchanged for both EH and N Ss for the Performance scale. Overall, and at Times 2 and 3, Verbal scores were lower for the EH group. It was concluded that neither decline nor improvement in cognitive function over time are necessary outcomes of modest, carefully treated, uncomplicated hypertension in the middle years.