Falling into language life: a montage of pre‐faces in search of a text‐ual body

Clinical work, as all of consciousness, is steeped in and emerges out of language. Language is the medium of our knowing, and knowing the medium of our relating. Language has us; words dream us. For the mythical Navajo as for John of the New Testament, in the Beginning was the Word. Before any kind of distinction of thought, feeling, sensation or intuition comes language – language, not as ‘just words’, but as image. Words are images, and images as encompassing worlds present themselves as and through language. As a determinant of identity, language undermines all cues as to individual subjectivity, Yahweh's ‘I am here’ rendering time and place relative, and subjectivity co‐constituted. This paper is a meditation on language for clinicians in the form that language presents itself, as a meandering flow of consciousness with associations and signposts leading onward.     

Maternal pre‐ and postnatal anxiety and infant temperament. The generation R study

The aim of this study was to investigate whether maternal anxiety that is temporary or chronic during the pre‐ and postnatal period predicts infant temperament. Mothers of 2997 infants in a population‐based birth cohort reported levels of pregnancy‐specific anxiety (Pregnancy Outcome Questionnaire) and general anxiety symptoms (Brief Symptom Inventory) prenatal and at 6 months postnatal. Temperament characteristics were assessed by maternal report using the Infant Behavior Questionnaire—Revised when the infants were 6 months of age. Maternal pregnancy‐specific and general anxiety during the pre‐ and postnatal period were all independently associated with perceived infant temperamental difficulties. Chronically high maternal anxiety predicted the highest perceived infant activity level and negative affectivity. These findings show that different forms of maternal anxiety during both the pre‐ and postnatal period are independently related to perceived temperamental problems in infancy. They also emphasize the significance of chronic maternal anxiety for infant mental health. Copyright © 2009 John Wiley & Sons, Ltd.     

Development of place navigation in rats from weaning to puberty

Young hooded rats were trained to escape onto a hidden platform after swimming in a pool of opaque water. Subjects 21, 28, 35, 42, and 64 days of age on the first training day were given 28 trials on 5 consecutive days. Half of the rats were required to localize the platform in relation to external room cues only ("place only" condition) and the other half were helped by the presence of a visible cue on the platform ("cue + place" condition). A deficiency in place navigation was observed in the 21- and 28-day groups; they showed slow escape and took circuitous routes more often than older rats. This deficiency was related to a poor spatial bias toward the training position when the subjects were allowed to swim for 30 s in the absence of the platform, at the end of the 28-trial training period (probe trial). The 35-day group showed adult-like learning ability in both training conditions, but failed to show searching behavior during the probe trial after having been trained in the presence of the proximal cue. Only rats older than 40 days showed typical adult behavior such as swimming directly toward the platform from any starting position and localized searching around the absent platform's position during the probe trial, no matter what the training conditions were. These results suggest that central nervous system structures responsible for place learning in the rat are functional from around 32 days of age, but fail to trigger searching behavior following cued training before the sixth week.     

Diurnal cortisol rhythm and cognitive functioning in toddlers: The Generation R Study

Little is known about the relationship between diurnal cortisol secretion patterns and cognitive function early in life. This population-based study examined whether diurnal cortisol rhythms and cognitive functioning in toddlers are related. Within the Generation R Study, parents of 364 infants (median age: 14.2 months) collected saliva samples at five moments during one day. We assessed the diurnal cortisol rhythm by calculating the area under the curve (AUC), the cortisol awakening response (CAR), and the diurnal slope. Verbal cognitive functioning and fine motor development was determined at age 18 months. Nonverbal cognitive functioning was assessed at age 30 months. A more positive CAR was associated with a lower risk of delay in language comprehension (OR per 1-SD CAR: 0.62, 95%CI: 0.40–0.98, p = .04), a lower risk of nonoptimal fine motor development (OR per 1-SD slope: 0.74, 95%CI: 0.57–0.96, p = .03), and a lower risk of delay in nonverbal cognitive development (OR per 1-SD CAR: 0.58, 95%CI: 0.38–0.90, p = .02). Also, children with flatter slopes had a lower risk of delay in nonverbal cognitive development (OR per 1-SD slope: 0.51, 95%CI: 0.34–0.76, p = .001). Higher AUC levels were associated with a higher risk of delay in language production. These results show that variations in diurnal cortisol rhythms are already associated with variations in cognitive functioning at a young age. Infants with a diurnal cortisol pattern indicative of less stress and more cortisol reactivity, that is, lower AUC levels and a more positive CAR, show a lower risk of delay in cognitive functioning as toddlers.     

Changes in the gangliosides of erythrocyte membranes of schizophrenic patients

The pattern of gangliosides in membranes of erythrocytes was examined in healthy donors, in acute schizophrenics without neuroleptic treatment and in alcohol-dependent patients. 7 different gangliosides could be detected after extraction, purification by column chromatography and fractionation by TLC. Healthy donors were characterized by the following pattern of gangliosides: GX = 5.8%, GT1b = 6.7%, FucGD1b = 5.2%, und GD1a = 12.6%, GD3 = 9.2%, SPG = 43.5% and GM3 = 17.0%. In schizophrenic patients the GM3- and GD3-fraction were increased. No difference was found between the control group and the alcoholics.     

The influence of a career group experience on the vocational maturity of college students

The effects of a career group experience on the vocational maturity of theoretically grouped college freshmen and sophomores were investigated using Super's Career Development Inventory as the dependent measure. The dimensions of consistency/inconsistency and differentiation/nondifferentiation, as identified utilizing Holland's Vocational Preference Inventory, were investigated along with the dimensions of treatment/nontreatment and interaction effects. Predictions related to change in vocational maturity as a result of treatment were made for each dimension. The analysis sample was a group of 68 volunteer freshman and sophomore college students. Results indicated that students did significantly increase their vocational maturity as a result of the group experience. Furthermore, it was found, as predicted, that within experimental groups inconsistent and nondifferentiated students improved significantly more on some vocational maturity measures than consistent or differentiated students. Students who were both inconsistent and nondifferentiated showed consistently greater increases on virtually all vocational maturity measures than all other theoretical groups.     

An Examination of the Role of Mentees’ Social Skills and Relationship Quality in a School-Based Mentoring Program

Research on youth mentoring highlights the importance of the relationship quality between mentor and mentee; mentoring results in more positive outcomes when the mentee perceives the relationship as satisfying and trustworthy. Research on relationship quality shows that social skills are important for constructing new relationships. However, whereas improved social skills are often one of the main goals of youth mentoring, little is known about the importance of social skills for relationship quality in youth mentoring relations. In this study, we examined whether mentee's pre-intervention social skills were related to mentor–mentee relationship quality as perceived by the mentee, and in turn, if relationship quality was associated with post-intervention social skills. We additionally examined possible gender and age differences in these associations. Data were used from a two-wave study that assessed relationship quality and social skills before and after one semester of mentoring of 390 secondary school students in a school-based mentoring program. Results indicated that relationship quality was positively associated with post-intervention social skills. However, only for young mentees pre-intervention social skills were associated with better relationship quality. Moreover, only for young mentees, relationship quality mediated the association between pre- and post-intervention social skills.     

Testing a Relational Model of Psychopathology With the MMPI-2

The purpose of this study is to validate a relational, contextual selfhood model of psychopathology with the MMPI-2. Positive and negative attributions of importance to self and intimate others were hypothesized as producing four personality propensities: a functional one, self-fullness, and three dysfunctional ones or extreme deviations, selfishness or externalization, selflessness or internalization, and no-self and psychopathology. These propensities have meaning specifically in intimate (committed, prolonged, and close) relationships and may not generalize to public, short-lived, or superficial, ones. Four algorithms, composed from validity and clinical scales of the MMPI-2, evaluated whether the four personality propensities of the model can be validated with the MMPI-2. An early study using undergraduates gave some support for the reliability of classifications obtained from the four algorithms. However, the use of nonclinical cases and the lack of an external criterion to evaluate level and type of psychopathology required a larger sample of clinical cases and the use of an external criterion. Both criteria were met with a much larger clinical sample with one external criterion about type and extent of psychopathology, the Multiaxial Diagnostic Inventories (MDI) using ratings by respondents themselves and diagnoses by psychologists evaluating them. The results of the MDI tended to support possible links between the relational model and an empirical test like the MMPI-2.     

Enhanced visuospatial memory following intracerebroventricular administration of nerve growth factor

The present work assessed the effects of intracerebroventricular injections of rh recombined human nerve growth factor (rh NGF) (5 micrograms/2.5 microl) at postnatal days 12 and 13 upon the development of spatial learning capacities. The treated rats were trained at the age of 22 days to escape onto an invisible platform at a fixed position in space in a Morris navigation task. For half of the subjects, the training position was also cued, a procedure aimed at facilitating escape and at reducing attention to the distant spatial cues. Later, at the age of 6 months, all the rats were trained in a radial-arm maze task. Treatment effects were found in both immature and adult rats. The injection of NGF improved the performance in the Morris navigation task in both training conditions. There was a significant reduction in the escape latency and an increased bias toward the training platform quadrant during probe trials. The most consistent effect was the precocious development of an adult-like spatial memory. In the radial-arm maze, the NGF-treated rats made significantly fewer reentries than vehicle rats and this effect was particularly marked in the treated female rats. Taken together, these experiments reveal that the development and the maintenance of an accurate spatial representation are tightly related to the development of brain structures facilitated by the action of NGF. Moreover, these experiments demonstrate that an acute pharmacological treatment that leads to a transient modification in the choline acetyltransferase activity can induce a behavioral change long after the treatment.