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81.
Mizoguchi N Fujita S Koshikawa N Kobayashi M 《Neurobiology of learning and memory》2011,96(3):468-478
Long-term potentiation (LTP) of the gustatory cortex (GC), a part of the insular cortex (IC) around the middle cerebral artery, is a key process of gustatory learning and memory, including conditioned taste aversion learning. The rostral (rGC) and caudal GC (cGC) process different tastes; the rGC responds to hedonic and the cGC responds to aversive tastes. However, plastic changes of spatial interaction of excitatory propagation between the rGC and cGC remain unknown. The present study aimed to elucidate spatiotemporal profiles of excitatory propagation, induced by electrical stimulation (five train pulses) of the rGC/cGC before and after LTP induction, using in vivo optical imaging with a voltage-sensitive dye. We demonstrated that tetanic stimulation of the cGC induced long-lasting expansion of the excitation responding to five train stimulation of the cGC, and an increase in amplitude of optical signals in the IC. Excitatory propagation after LTP induction spread preferentially toward the rostral IC: the length constant (λ) of excitation, obtained by fitting optical signals with a monoexponential curve, was increased to 121.9% in the rostral direction, whereas λ for the caudal, dorsal, and ventral directions were 48.9%, 44.2%, and 62.5%, respectively. LTP induction was prevented by pre-application of D-APV, an NMDA receptor antagonist, or atropine, a muscarinic receptor antagonist, to the cortical surface. In contrast, rGC stimulation induced only slight LTP without direction preference. Considering the different roles of the rGC and cGC in gustatory processing, these characteristic patterns of LTP in the GC may be involved in a mechanism underlying conversion of palatability. 相似文献
82.
When using precision grip to pick up objects, there are many possible pairs of grasp points that permit the thumb and index finger to exert opposed forces for secure grip. Previously, it was shown that individuals select grasp points so that the line between them (grasp axis) passes through or near the center of mass (CoM), thus minimizing the torque around the grasp axis during lifting. The accuracy of grasp axis selection depended on object spatial symmetry, indicating the importance of vision. The authors investigated how grasp point selection is influenced by haptic as well as visual information. Ten participants lifted cuboids whose CoM was located either symmetrically in the geometric center or asymmetrically toward one end. Results for the asymmetric cuboid revealed that grasp points migrated toward the asymmetric CoM from the geometric center. This was more pronounced in the presence of visual cues that reliably indicated the location of CoM. The results suggest that grasp point selection is influenced by a multimodal representation of CoM. 相似文献
83.
This study investigated how the temporal characteristics, particularly durations, of sounds affect the perceived duration of very short interonset time intervals (120-360?ms), which is important for rhythm perception in speech and music. In four experiments, the subjective duration of single time intervals marked by two sounds was measured utilizing the method of adjustment, while the markers' durations, amplitude difference (which accompanied the duration change), and sound energy distribution in time were varied. Lengthening the duration of the second marker in the range of 20-100?ms increased the subjective duration of the time interval in a stable manner. Lengthening the first marker tended to increase the subjective duration, but unstably; an opposite effect sometimes appeared for the shortest time interval of 120?ms. The effects of varying the amplitude and the sound energy distribution in time of either marker were very small in the present experimental conditions, thus proving the effects of marker durations per se. 相似文献
84.
Hiroto Okouchi Satoshi Nakamura Sota Watanabe Kennon A. Lattal 《Journal of the experimental analysis of behavior》2021,116(1):82-95
Four pigeons were exposed to a tandem variable-interval (VI) fixed-ratio (FR) schedule in the presence of a 50-pixel (about 15 mm) square or an 80-pixel (about 24 mm) square and to a tandem VI differential-reinforcement-of-low-rate (DRL) schedule when a second 80-pixel or 50-pixel square was present. The values of the VI and FR schedules were adjusted to equate reinforcement rates in the two tandem schedules. Following this, a square-size continuum generalization test was administered under a fixed-interval (FI) schedule or extinction. In the first testing session, response frequency was a graded function of the similarity of the test stimuli to the training stimuli for all pigeons. These systematic generalization gradients persisted longer under the FI schedule than under extinction. 相似文献
85.
Ping Yeap Loh Keisuke Hayashi Nursalbiah Nasir Satoshi Muraki 《Journal of motor behavior》2020,52(5):634-642
AbstractThis study investigated the muscle activity and force variability in response to perturbation of assistive force during isometric elbow flexion. Sixteen healthy right-handed young men (age: 22.0?±?1.1?years; height: 171.9?±?4.8?cm; weight 68.4?±?11.2?kg) were recruited and the muscle activity of biceps brachii and triceps brachii were assessed using surface electromyography. Workload force and assistive force applied on isometric elbow flexion significantly affected the changes in both biceps and triceps muscle activities. A higher assistive force was shown to result in reduced biceps muscle activity compared to the unassisted period. In contrast, the efficiency of the assistive force acting on the biceps decreased as the assistive force increased. In general, the force variability of the biceps muscle remained approximately the same at lower workload force conditions than that at higher workload force conditions. In conclusion, higher assistive force may not yield a higher performance efficiency in human-assistive force interaction. 相似文献