Conditioned fear is modulated by D2 receptor pathway connecting the ventral tegmental area and basolateral amygdala

Excitation of the mesocorticolimbic pathway, originating from dopaminergic neurons in the ventral tegmental area (VTA), may be important for the development of exaggerated fear responding. Among the forebrain regions innervated by this pathway, the amygdala is an essential component of the neural circuitry of conditioned fear. The functional role of the dopaminergic pathway connecting the VTA to the basolateral amygdala (BLA) in fear and anxiety has received little attention. In vivo microdialysis was performed to measure dopamine levels in the BLA of Wistar rats that received the dopamine D(2) agonist quinpirole (1 μg/0.2 μl) into the VTA and were subjected to a fear conditioning test using a light as the conditioned stimulus (CS). The effects of intra-BLA injections of the D(1) antagonist SCH 23390 (1 and 2 μg/0.2 μl) and D(2) antagonist sulpiride (1 and 2 μg/0.2 μl) on fear-potentiated startle (FPS) to a light-CS were also assessed. Locomotor performance was evaluated by use of open-field and rotarod tests. Freezing and increased dopamine levels in the BLA in response to the CS were both inhibited by intra-VTA quinpirole. Whereas intra-BLA SCH 23390 did not affect FPS, intra-BLA sulpiride (2 μg) inhibited FPS. Sulpiride's ability to decrease FPS cannot be attributed to nonspecific effects because this drug did not affect motor performance. These findings indicate that the dopamine D(2) receptor pathway connecting the ventral tegmental area and the basolateral amygdala modulates fear and anxiety and may be a novel pharmacological target for the treatment of anxiety.     

Emotional reactions to scandals: When does moral character make a difference?

A scandal can evoke public outrage when it is widely publicized and involves an individual who is perceived to have a high level of cultural representativeness. Two experiments showed that when the scandalous target's moral character was highlighted, emotional responses towards the target were least negative when the scandal was widely circulated and when the target was seen as a representative of his culture. These results suggest that when a cultural symbol is implicated in a widely‐circulated scandal, the negative emotions directed towards the scandalous individual can be alleviated when the public remains confident in his or her commitment to morality.     

The sound of enemies and friends in the neighborhood

Previous studies (e.g., Pecher, Zeelenberg, & Wagenmakers, 2005) found that semantic classification performance is better for target words with orthographic neighbors that are mostly from the same semantic class (e.g., living) compared to target words with orthographic neighbors that are mostly from the opposite semantic class (e.g., nonliving). In the present study we investigated the contribution of phonology to orthographic neighborhood effects by comparing effects of phonologically congruent orthographic neighbors (book-hook) to phonologically incongruent orthographic neighbors (sand-wand). The prior presentation of a semantically congruent word produced larger effects on subsequent animacy decisions when the previously presented word was a phonologically congruent neighbor than when it was a phonologically incongruent neighbor. In a second experiment, performance differences between target words with versus without semantically congruent orthographic neighbors were larger if the orthographic neighbors were also phonologically congruent. These results support models of visual word recognition that assume an important role for phonology in cascaded access to meaning.     

Awakening: Career Opportunities After the Storm

Immediately following natural disasters, basic needs are provided; however, the long‐term needs of individuals are neglected. The narrative approach (Brott, 2001; Cochran, 1997) to career counseling is offered as a method to assist survivors of natural disasters to tell their story and create new meaning related to their career paths.     

Embodied Cultural Cognition: Situating the Study of Embodied Cognition in Socio‐Cultural Contexts

Embodiment research has demonstrated that cognition is grounded in bodily interactions with the environment and that abstract concepts are tied to the body’s sensory and motor systems. Building upon this embodiment perspective and advancing our understanding, we discuss the extension of embodied cultural cognition. We propose that some associations between bodily experiences and abstract concepts are not randomly formed; rather, the development of such associations is situated in a socio‐cultural context, informed by cultural imperatives, values, and habits. We draw evidence supporting this view of embodied cultural cognition in body–mind linkages manifested in construal of emotions, time perception, person perception, social power, and moral reasoning. To further extend this research avenue that synthesizes the studies of embodied cognition and culture, we also suggest potential future research directions inspired by this view. This embodied cultural cognition account is useful in understanding and organizing accumulating discoveries of cultural variations in embodiments; it also highlights the social situatedness of embodied cognition and is, therefore, highly compatible with theorizing and research in social and cultural psychology.     

The role of encoding strategies in the verbal memory performance in patients with schizophrenia

Background. Verbal learning and memory is often compromised in patients with schizophrenia who prefer encoding words in order of their presentation (serial clustering) rather than using semantic categories (semantic clustering). Method. One hundred and four in‐patients with schizophrenia were assessed twice with the California Verbal Learning Test. Results. Patients showed significantly less semantic than serial clustering at both assessment times. Usage of encoding strategies were not stable over time. An increase in semantic clustering improved recall and recognition performance. Conclusions. Patients with schizophrenia should be taught to use the more effective encoding strategy of semantic clustering in order to improve their memory performance.     

Resilience: A Disability Studies and Community Psychology Approach

This paper contests traditional psychological understandings of resilience through reference to a research project exploring resilience in the lives of disabled people. The paper briefly historically locates individualistic accounts of resilience (which have often been unhelpful in the lives of disabled people) and then moves into more recent social constructionist theories of this phenomenon. This latter perspective necessarily locates resilience in a network of resources including material resources, relationships, identity, bodies and minds, power and control, community participation, community cohesion and social justice. We argue that the recognition of resilience as a relational product is important and in tune with attempts to make psychology less an individualistic encounter and more a community intervention. However, disabled people, their politics and the development of critical disability studies, contest and challenge normative ideas of what it means to live with a resilient network of resources. In this sense disability offers new and exciting ways of addressing resilience.     

Behavioral lateralization during spontaneous smelling tasks

The smelling behavior of 52 right-handed subjects was videotaped during tasks involving identification and recognition of different odors. Analysis showed that men more often used the right nostril than the left whatever the odor. There was no significant difference for the women. These results support a more marked cerebral asymmetry in men than in women and a main involvement of the right cerebral hemisphere in the olfactory processes at least by right-handed men.     

Conditioned and unconditioned fear organized in the periaqueductal gray are differentially sensitive to injections of muscimol into amygdaloid nuclei

The lateral and basolateral nuclei of the amygdala (LaA and BLA, respectively) serve as a filter for unconditioned and conditioned aversive information that ascends to higher structures from the brainstem, whereas the central nucleus of the amygdala (CeA) is considered to be the main output for the defense reaction. It has been shown that the dorsal periaqueductal gray (dPAG) is activated by threatening stimuli and has important functional links with the amygdala through two-way anatomical connections. In this work, we examined the influence of chemical inactivation of these nuclei of amygdala on the freezing and escape responses induced by electrical stimulation through electrodes implanted in the dPAG of Wistar rats. Each rat also bore a cannula implanted in the LaA, BLA or CeA for injections of muscimol (0.5 microg/0.5 microL) or its vehicle. The duration of freezing behavior that outlasts electrical stimulation of the dPAG was also measured. On the following day, these animals were submitted to a contextual fear-conditioning using foot shocks as unconditioned stimulus. Conditioned freezing to contextual cues previously associated with foot shocks was also inhibited by injections of muscimol into these amygdaloid nuclei. The contextual conditioned freezing behavior is generated in the neural circuits of conditioned fear in the amygdala. The data obtained also show that injections of muscimol into the three amygdaloid nuclei did not change the aversive threshold of freezing, but disrupted the dPAG post-stimulation freezing. Previous findings that the latter freezing results directly from dPAG stimulation and that it is not sensitive to a context shift suggest that it is unconditioned in nature. Thus, the amygdala can affect some, but not all, aspects of unconditioned freezing. Post-stimulation freezing may reflect the process of transferring aversive information from dPAG to higher brain structures.     

Child and mother variables in the development of stuttering among high-risk children: A longitudinal study

In this prospective study, 26 of the 93 preschool children with a parental history of stuttering who began to stutter were compared at preonset and 1 year later with those of a matched group of 26 children who continued to be seen as nonstutterers. These two groups of at-risk children were compared in terms of the development of their articulatory and language skills and in terms of the communicative style and speaking behaviors of their mothers. At preonset, the children who started to stutter demonstrated a faster articulatory rate than those who remained fluent. One year later, however, this difference was no longer statistically significant. The two groups of children did not differ in their linguistic skills at either of these time periods. Moreover, the communicative style and speaking behaviors of the mothers of the children who later began to stutter did not differ from that of the mothers of children who did not either prior to or after the onset of stuttering. This suggests that these variables did not contribute to the onset of stuttering or to its course.