Working with Research Integrity—Guidance for Research Performing Organisations: The Bonn PRINTEGER Statement

This document presents the Bonn PRINTEGER Consensus Statement: Working with Research Integrity—Guidance for research performing organisations. The aim of the statement is to complement existing instruments by focusing specifically on institutional responsibilities for strengthening integrity. It takes into account the daily challenges and organisational contexts of most researchers. The statement intends to make research integrity challenges recognisable from the work-floor perspective, providing concrete advice on organisational measures to strengthen integrity. The statement, which was concluded February 7th 2018, provides guidance on the following key issues:

1. § 1.
   Providing information about research integrity
    
2. § 2.
   Providing education, training and mentoring
    
3. § 3.
   Strengthening a research integrity culture
    
4. § 4.
   Facilitating open dialogue
    
5. § 5.
   Wise incentive management
    
6. § 6.
   Implementing quality assurance procedures
    
7. § 7.
   Improving the work environment and work satisfaction
    
8. § 8.
   Increasing transparency of misconduct cases
    
9. § 9.
   Opening up research
    
10. § 10.
    Implementing safe and effective whistle-blowing channels
     
11. § 11.
    Protecting the alleged perpetrators
     
12. § 12.
    Establishing a research integrity committee and appointing an ombudsperson
     
13. § 13.
    Making explicit the applicable standards for research integrity
     

     

Socioeconomic status and hippocampal volume in children and young adults

An individual's socioeconomic status (SES) is often viewed as a proxy for a host of environmental influences. SES disparities have been linked to variance in brain structures particularly the hippocampus, a neural substrate of learning and memory. However, it is unclear whether the association between SES and hippocampal volume is similar in children and adults. We investigated the relationship between hippocampal volume and SES in a group of children (n = 31, age 8–12 years) and a group of young adults (n = 32, age 18–25 years). SES was assessed with four indicators that loaded on a single factor, therefore a composite SES scores was used in the main analyses. Hippocampal volume was measured using manual demarcation on high resolution structural images. SES was associated with hippocampal volume in the children, but not in adults, suggesting that in childhood, but not adulthood, SES‐related environmental factors influence hippocampal volume. In addition, hippocampal volume, but not SES, was associated with scores on a memory task, suggesting that net effects of postnatal environmental factors, captured by SES, are more distal determinants of memory performance than hippocampal volume. Longitudinal investigation of the association between SES, hippocampal volume and cognitive functioning may further our understanding of the putative neural mechanisms underlying SES‐related environmental effects on cognitive development.     

The influence of pubertal maturation on antisaccade performance

Adolescence is a period characterized by continued improvements in inhibitory control, and this persisting immaturity is believed to interact with affective/motivational behavior to generate the impulsive and risk‐taking behavior evidenced at this time. Puberty is a central event of adolescence that has been shown to influence affective/motivational behavior. However, despite plausible mechanisms by which puberty might influence inhibitory control, researchers have yet to test this possibility rigorously. Thus, we designed a study to examine the unique role of pubertal maturation, independent of age, in the development of inhibitory control. In order to minimize age‐related variability while maximizing pubertal status variability, we recruited 78 participants (34 F) whose ages narrowly spanned the mean age of gonadarche for each sex (F: ages 11–13, M: ages 12–14). Two complementary measures were used to assess pubertal status: (1) circulating blood serum testosterone and estradiol levels reflecting internal manifestations of pubertal maturation, and (2) Tanner staging by a trained nurse reflecting pubertal maturation's external manifestations. Inhibitory control was assessed using the antisaccade task, and findings were adjusted for the potential effect of age. Results revealed no association between testosterone levels and error rates or response latencies in either sex. In girls, estradiol levels were not associated with error rates, but were associated with faster response latencies. There was similarly no association between Tanner status and error rates, although girls in more advanced pubertal stages showed faster response latencies. Power analyses indicate that findings of a lack of association did not reflect limited statistical power. Thus, in a study designed to isolate the effects of pubertal maturation independent of age, both external and internal indices of pubertal maturation converged to indicate that age‐related improvements in cold antisaccade performance are independent of pubertal maturation.     

Speaking a tone language enhances musical pitch perception in 3–5‐year‐olds

Young children learn multiple cognitive skills concurrently (e.g., language and music). Evidence is limited as to whether and how learning in one domain affects that in another during early development. Here we assessed whether exposure to a tone language benefits musical pitch processing among 3–5‐year‐old children. More specifically, we compared the pitch perception of Chinese children who spoke a tone language (i.e., Mandarin) with English‐speaking American children. We found that Mandarin‐speaking children were more advanced at pitch processing than English‐speaking children but both groups performed similarly on a control music task (timbre discrimination). The findings support the Pitch Generalization Hypothesis that tone languages drive attention to pitch in nonlinguistic contexts, and suggest that language learning benefits aspects of music perception in early development. A video abstract of this article can be viewed at: https://youtu.be/UY0kpGpPNA0     

Early development of letter specialization in left fusiform is associated with better word reading and smaller fusiform face area

A functional region of left fusiform gyrus termed “the visual word form area” (VWFA) develops during reading acquisition to respond more strongly to printed words than to other visual stimuli. Here, we examined responses to letters among 5‐ and 6‐year‐old early kindergarten children (N = 48) with little or no school‐based reading instruction who varied in their reading ability. We used functional magnetic resonance imaging (fMRI) to measure responses to individual letters, false fonts, and faces in left and right fusiform gyri. We then evaluated whether signal change and size (spatial extent) of letter‐sensitive cortex (greater activation for letters versus faces) and letter‐specific cortex (greater activation for letters versus false fonts) in these regions related to (a) standardized measures of word‐reading ability and (b) signal change and size of face‐sensitive cortex (fusiform face area or FFA; greater activation for faces versus letters). Greater letter specificity, but not letter sensitivity, in left fusiform gyrus correlated positively with word reading scores. Across children, in the left fusiform gyrus, greater size of letter‐sensitive cortex correlated with lesser size of FFA. These findings are the first to suggest that in beginning readers, development of letter responsivity in left fusiform cortex is associated with both better reading ability and also a reduction of the size of left FFA that may result in right‐hemisphere dominance for face perception.     

Beyond the broom cupboard: teaching assistants’ reflections upon the wider impact of their specialist dyslexia training

Whilst the government-commissioned Rose Report (2009) on provision and support for dyslexic learners in England called for the deployment of more specialist dyslexia teachers in mainstream schools, the reality seems to be that the job of teaching literacy to children with dyslexia is falling to teaching assistants (TAs). As a result, specialist training courses for TAs have been developed in England. Using the Coldwell and Simkins Training Impact Framework, the present study examines TAs participants’ perceptions of the impact of two such local authority-based training programmes, not just in terms of the impact upon their individual practice, but also in terms of their perceptions of the wider impact of their status as a trained ‘expert’ upon their schools’ policies, culture and practice. ‘Enabling’ and ‘blocking’ factors influencing this wider impact are identified, and implications for the deployment of specialist TAs and the design of their training courses are discussed.     

Beyond Consent: Building Trusting Relationships With Diverse Populations in Precision Medicine Research

With the growth of precision medicine research on health data and biospecimens, research institutions will need to build and maintain long-term, trusting relationships with patient-participants. While trust is important for all research relationships, the longitudinal nature of precision medicine research raises particular challenges for facilitating trust when the specifics of future studies are unknown. Based on focus groups with racially and ethnically diverse patients, we describe several factors that influence patient trust and potential institutional approaches to building trustworthiness. Drawing on these findings, we suggest several considerations for research institutions seeking to cultivate long-term, trusting relationships with patients: (1) Address the role of history and experience on trust, (2) engage concerns about potential group harm, (3) address cultural values and communication barriers, and (4) integrate patient values and expectations into oversight and governance structures.