Person Skilled in the Art in Synthetic Biology from Iraqi and Malaysian Perspectives

This article presents the problem of a person skilled in the field of synthetic biology. The person skilled in the art is one of the notions which have to be revisited due to the multidisciplinary nature of synthetic biology which involves numerous fields. The article studies this problem from the perspectives of Iraqi and Malaysian patent laws. First, it conceptualizes synthetic biology and person skilled in the art. The Iraqi and Malaysian attitudes regarding person skilled in the art are then addressed. Afterwards, the paper points out the multidisciplinary nature of synthetic biology. In its last part, it discusses the person skilled in synthetic biology and how patent offices and courts deal with this point. Finally, the authors submit that the use of a team of skilled persons to substitute for a single technician would render the obviousness test a subjective assessment dependent on the inventor. The level of non-obviousness would differ in similar cases simply because of the number of inventors. Consequently, the suggestion of having a hypothetical team instead of one person is irrelevant because skills that are attributed to the skilled notional person are not real skills. Thus, replacing him is easy, but the replacement would be fruitless because the skills attributed to a person or a team will be similar.     

The Power of Analogies for Imagining and Governing Emerging Technologies

The emergence of new technologies regularly involves comparisons with previous innovations. For instance, analogies with asbestos and genetically modified organisms have played a crucial role in the early societal debate about nanotechnology. This article explores the power of analogies in such debates and how they could be effectively and responsibly employed for imagining and governing emerging technologies in general and nanotechnology in particular. First, the concept of analogical imagination is developed to capture the explorative and anticipatory potential of analogies. Yet analogies do not simply stimulate imagination, they also restrict it by framing emerging technologies in specific ways. Thus, second, the article argues that tracing the rhetorical and persuasive power of analogical arguments is essential for understanding how analogies are constructed to legitimise assessments, funding policies, and governance approaches. Third, the article addresses factors that account for the persuasiveness of analogies in debates about emerging technologies. The article concludes with reflections on how analogical imagination and an enhanced analogical sensibility for framing and persuasive effects can foster responsible research and innovation (RRI).     

Models of Public Engagement: Nanoscientists’ Understandings of Science–Society Interactions

This paper explores how scientists perceive public engagement initiatives. By drawing on interviews with nanoscientists, it analyzes how researchers imagine science–society interactions in an early phase of technological development. More specifically, the paper inquires into the implicit framings of citizens, of scientists, and of the public in scientists’ discourses. It identifies four different models of how nanoscientists understand public engagement which are described as educational, paternalistic, elitist, and economistic. These models are contrasted with the dialog model of public engagement promoted by social scientists and policymakers. The paper asks if and in what ways participatory discourses and practices feed back into scientists’ understandings, thus co-producing public discourses and science.     

Frame Reflection Lab: a Playful Method for Frame Reflection on Synthetic Biology

Synthetic biology is an emerging technology that asks for inclusive reflection on how people frame the field. To unravel how we can facilitate such reflection, this study evaluates the Frame Reflection Lab (FRL). Building upon playfulness design principles, the FRL comprises a workshop with video-narratives and co-creative group exercises. We studied how the FRL facilitated frame reflection by organizing workshops with various student groups. Analysis of 12 group conversations and 158 mini-exit surveys yielded patterns in first-order reflection (problem analysis and solution finding in reflection on the development of synthetic biology as a field) as well as patterns in second-order reflection (reflection on values and assumptions underlying the first-order reflection). Also patterns in participants’ (re)framing of synthetic biology could be induced; participants’ viewpoints converged to some extent, yet with openness to individual viewpoint differences. Although the FRL method fortified the reflection processes of participants, the narratives and the workshop’s flexible format could inhibit the reflection too. Therefore, we advise designers of future frame reflection methods to apply stronger conversational facilitation and narratives of slightly mysterious yet identifiable narrators, in case e.g. video-narratives are created and used to scaffold the reflection process. Nevertheless, we argue that the use of a playful frame reflection method like the FRL could function well as (1) a step to precede more application-specific deliberation or decision-making on synthetic biology and as (2) a method for the collection of contemporary citizen viewpoints plus rationales underlying these, for the further (societally) responsible development of the emerging field.     

Giving Voice to Patients: Developing a Discussion Method to Involve Patients in Translational Research

Biomedical research policy in recent years has often tried to make such research more ‘translational’, aiming to facilitate the transfer of insights from research and development (R&D) to health care for the benefit of future users. Involving patients in deliberations about and design of biomedical research may increase the quality of R&D and of resulting innovations and thus contribute to translation. However, patient involvement in biomedical research is not an easy feat. This paper discusses the development of a method for involving patients in (translational) biomedical research aiming to address its main challenges.After reviewing the potential challenges of patient involvement, we formulate three requirements for any method to meaningfully involve patients in (translational) biomedical research. It should enable patients (1) to put forward their experiential knowledge, (2) to develop a rich view of what an envisioned innovation might look like and do, and (3) to connect their experiential knowledge with the envisioned innovation. We then describe how we developed the card-based discussion method ‘Voice of patients’, and discuss to what extent the method, when used in four focus groups, satisfied these requirements. We conclude that the method is quite successful in mobilising patients’ experiential knowledge, in stimulating their imaginaries of the innovation under discussion and to some extent also in connecting these two. More work is needed to translate patients’ considerations into recommendations relevant to researchers’ activities. It also seems wise to broaden the audience for patients’ considerations to other actors working on a specific innovation.     

A Study on the Linkages between Residential Satisfaction and the Overall Quality of Life in Bandar Tun Razak Area of Kuala Lumpur City,Malaysia

This paper provides an assessment of the links between residential satisfaction with the housing sector and the overall quality of life (QOL) in Bandar Tun Razak area (BTR). As the QOL concept is multidimensional, five domains were selected to measure the overall QOL namely; economic capacity, safety condition, social involvement and community participation, physical and emotional health, and spiritual life. While for the housing sector, the study involved 32 indicators that cover the different housing features. Besides, In order to obtain a representative sample, a stratified convenient sampling was employed and 331 questionnaires were collected. The findings show that respondents were slightly unsatisfied with safety condition and economic capacity, whereas they were only slightly satisfied with social and community participation which require further attention to the improvement of these three domains. Moreover, Exploratory Factor Analysis (EFA) was applied on the housing indicators resulting in the extraction of five factors which are: housing size, neighbourhood quality, public facilities, housing suitability, and housing quality. Among these five factors, it was found that the housing size affects the overall residential satisfaction highly. Eventually, a path diagram was employed to measure links between the housing sub-domains and QOL domains. The results show that the housing size and public facilities influence the economic capacity domain effectively. While the neighbourhood quality and housing suitability affect both safety condition and social and community participation domains.     

A Cyberbullying Intervention for Hong Kong Chinese College Students

A cyberbullying intervention was developed and empirically tested with 137 Hong Kong Chinese College students. The intervention was designed to change students’ attitudes about cyberbullying behavior and increase their awareness of cyberbullying. Participants were assigned to an experimental or control group. They completed questionnaires before the intervention (Time 1; T1), immediately after the intervention (Time 2; T2), and again eight weeks later (Time 3; T3). The experimental group participated in a 1-h intervention where they were presented with a simulated Facebook page showing the helpless feelings of cyber-victims, watched video clips of the consequences of cyberbullying, and engaged in small group discussions and a self-reflection writing task. Results showed that participants who received the intervention experienced an increase in their awareness and had more negative attitudes toward cyberbullying (i.e., the perception that cyberbullying is unacceptable behavior) than did the control group. In addition, those who reported being highly engaged in the intervention maintained the positive effects at the 8-week follow-up. The results demonstrate the feasibility and effectiveness of a short-term cyberbullying intervention for college students and that level of participant engagement contributes to its effectiveness.     

Cognitive-Behavioural Group Therapy for Pure Victims with Internalizing Problems: An Evidence-based One-year Longitudinal Study

The present study evaluates a specific cognitive-behavioural group intervention for pure victims of school bullying, employing a longitudinal design with mixed methods. 68 high-risk pure victims were identified from 5071 schoolchildren through screening measures and structured interviews, and assigned to 10 treatment groups. They completed a self-report questionnaire comprising measures of anxious/depressed problems and peer victimization prior and after the treatment, and at 1-year follow-up. The students, their teachers, and parents/guardians also received structural interview assessing students’ cognition, affection, and behaviour pertaining to peer victimization before and after the intervention. The results showed that the students’ physical, verbal, and total victimization, social exclusion, and depressed-anxious scores decreased from the pre-test to the one-year follow-up. They also reported a more realistic self-image, less self-blame, more positive outcome evaluation, less fearful, and employ more rational strategy when encountering problems in post-test interviews. Teachers and parents also noted the student experienced less peer victimization, had learnt to speak up against victimization and was less isolated in class. The results suggested the CBT program was effective for treating pure victims with internalizing problem.     

Quality of Life and Globalization: Evidence from Islamic Countries

This study analyzes the relationship between three dimensions (economic, social, and political) of globalization and quality of life using a panel of 44 Islamic countries from 1970 to 2010. Using different estimation techniques, we find that overall globalization has a robust positive effect on quality of life, even when controlling for income, dependency ratio, literacy, number of physicians, and other factors. Nevertheless, the results do not hold for all forms of globalization. Economic and political forms of globalization tend to improve quality of life. In contrast, social globalization does not improve quality of life.