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251.
Enriching the environment of alphaCaMKIIT286A mutant mice reveals that LTD occurs in memory processing but must be subsequently reversed by LTP
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Parsley SL Pilgram SM Soto F Giese KP Edwards FA 《Learning & memory (Cold Spring Harbor, N.Y.)》2007,14(1-2):75-83
alphaCaMKII(T286A) mutant mice lack long-term potentiation (LTP) in the hippocampal CA1 region and are impaired in spatial learning. In situ hybridization confirms that the mutant mice show the same developmental expression of alphaCaMKII as their wild-type littermates. A simple hypothesis would suggest that if LTP is a substrate for learning, then enriching the environment should cause learning-dependent changes in wild-type mice that have LTP. Such changes would not be seen in LTP-deficient alphaCaMKII(T286A) mutants. Excitatory synaptic currents in CA1 neurons, recorded with patch clamp in brain slices, revealed that enrichment induces an increase in glutamate release probability and a decreased miniature current amplitude. Confocal microscopy also showed dendritic spine density to be reduced. However, contrary to the hypothesis above, these enrichment-induced changes occur only in the mutant mice and are not detectable in wild-type littermates. We suggest that enrichment induces alphaCaMKII-independent changes in both wild-type and mutant mice. Such changes may be subsequently reversed in wild-type animals via alphaCaMKII-dependent mechanisms, such as LTP. Reversal of plasticity has long been hypothesized to be essential for the hippocampus to maintain its role in memory processing. The inability to reverse plasticity in alphaCaMKII(T286A) mutant mice would then result in impairment of spatial learning. 相似文献
252.
Parental personality as an inner resource that moderates the impact of ecological adversity on parenting 总被引:1,自引:0,他引:1
Kochanska G Aksan N Penney SJ Boldt LJ 《Journal of personality and social psychology》2007,92(1):136-150
Parents' personality was examined as a moderator of the impact of demographic risk on parenting in a longitudinal study (N=102 families). Parents' personality and demographic risk (i.e., education level, age, family income, and family size) were assessed when children were infants, and parents' power assertion, warmth, and positive affect were observed in naturalistic interactions 2.5 years later. Parents' personality moderated the adverse impact of demographic risk on parenting. For parents who had memories of unstable and unhappy childhood experiences and who reported low conventionality, higher risk was linked to more power assertion, but there was no such link for those parents who recalled happy childhood experiences and who embraced conventions. For both parents who lacked a sense of optimism and social trust, and for fathers who reported low conventionality, higher risk was linked to less affectively positive parenting, but there was no such link for parents who were optimistic and trusting or for fathers who were conventional. Higher risk was linked to more power assertion, but only for mothers low in Extraversion and for fathers high in Neuroticism. 相似文献
253.
Rein De Cooman Sara De Gieter Roland Pepermans Sabrina Hermans Cindy Du Bois Ralf Caers Marc Jegers 《Journal of Vocational Behavior》2009,74(1):102-107
Using the socialization and attraction-selection-attrition (ASA) frameworks, this study examined the relation between employees’ work values and their organization’s values (person-organization fit). With a two year time interval, 140 respondents participated in a longitudinal study. After entry, socialization served to enhance homogeneity. The work values underwent small changes and the perception of fit with the organization grew. Despite high retention rates results confirmed the attrition effect. Results indicated that the lower the perceived match between own and organizational values at entry, the more likely it was that someone left the organization over time. We concluded that socialization as well as attrition mechanisms were present at the same time. 相似文献
254.
Jacqueline S. Mattis Wizdom Powell Hammond Nyasha Grayman Meredith Bonacci William Brennan Sheri-Ann Cowie Lina Ladyzhenskaya Sara So 《American journal of community psychology》2009,43(1-2):71-84
Contemporary social science paints a bleak picture of inner-city relational life. Indeed, the relationships of low-income, urban-residing Americans are represented as rife with distress, violence and family disruption. At present, no body of social scientific work systematically examines the factors that promote loving or selfless interactions among low-income, inner-city American individuals, families and communities. In an effort to fill that gap, this ethnographic study examined the motivations for altruism among a sample of adults (n = 40) who reside in an economically distressed housing community (i.e., housing project) in New York City. Content analyses of interviews indicated that participants attributed altruism to an interplay between 14 motives that were then ordered into four overarching categories of motives: (1) needs-centered motives, (2) norm-based motives deriving from religious/spiritual ideology, relationships and personal factors, (3) abstract motives (e.g., humanism), and (4) sociopolitical factors. The implications of these findings are discussed. 相似文献
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257.
The age of acquisition (AoA) effect represents the processing advantage for developmentally earlier-acquired words. An initial norming study identified early and late AoA words having either a strong female-oriented (e.g., flute) or male-oriented (e.g., cigar) semantic bias. Forty-seven female and 45 male Scottish university students participated in a lexical decision task using 100 early and late AoA female- and male-oriented words. Reaction time data showed significant AoA effects for both females and males across both female- and male-oriented words, with faster responses to earlier than later acquired words. Females, however, took longer to respond to male-oriented words, particularly late AoA ones. Males demonstrated no effect of semantic gender. The pattern of effects is consistent with differential gender role socialization. 相似文献
258.
Aims: This qualitative study aimed to expand the limited evidence base about the long‐term effects of psychological therapies.Method: We conducted in‐depth interviews with 15 people, 1–3 years after primary care counselling, to investigate whether they could identify enduring benefits and the mechanisms that brought about and maintained them. From their narratives, we developed a model of the change process of counselling and mechanisms that were perceived as essential to produce lasting benefit. The model conceptualised movement through distinct phases: engagement; exploration of internal and external worlds; consolidation and negotiated ending. Results: Mechanisms integral to sustained impact were: the active engagement of people during and between sessions to work toward their own solutions; and acquisition through the change process of skills which could be further built on after the counselling ended. These enabled ongoing, dynamic change in the way people conducted their lives and relationships. Conclusion: A key concept in securing long‐term benefit was co‐production, both during counselling and in taking ownership of and using the ‘box of skills’ acquired. Support of the model was reinforced through comparison with the experience of three interviewees who reported no long‐term benefit. 相似文献
259.
Gilliam S Magliano JP Millis KK Levinstein I Boonthum C 《Behavior research methods》2007,39(2):199-204
We are constructing a new computerized test of reading comprehension called the Reading Strategy Assessment Tool (R-SAT).
R-SAT elicits and analyzes verbal protocols that readers generate in response to questions as they read texts. We examined
whether the amount of information available to the reader when reading and answering questions influenced the extent to which
R-SAT accounts for comprehension. We found that R-SAT was most predictive of comprehension when the readers did not have access
to the text as they answered questions. 相似文献
260.