Neuroplastic Changes Following Social Cognition Training in Schizophrenia: A Systematic Review

Social cognitive impairment is a key feature of schizophrenia and social cognition training (SCT) is a promising tool to address these deficits. Neurobiological dysfunction in schizophrenia has been widely researched, but neuronal changes induced by SCT have been scarcely explored. This review aims to assess the neuroplastic effects of SCT in patients with schizophrenia spectrum disorders. PubMed and Web of Science databases were searched for clinical trials testing the effects of SCT in functional and structural brain measurements of adult patients with schizophrenia or schizoaffective disorders. A total of 11 studies were included: five used fMRI, two used EEG and ERP, one used ERP only, two used MEG and one study used MRI. Data extracting and processing regarding sociodemographic and clinical variables, intervention characteristics, neuroimaging procedures, neuroplastic findings, effect sizes and study quality criteria was completed by two raters. Results indicate a wide range of structural and functional changes in numerous regions and circuits of the social brain, including early perceptual areas, the limbic system and prefrontal regions. Despite the small number of trials currently available, evidence suggests that SCT is associated with neuroplastic changes in the social brain and concomitant improvements in social cognitive performance. There is a lack of extensive knowledge about the neural mechanisms that underlie social cognitive enhancement after treatment, but the reported findings may shed light on the neural substrates of social cognitive impairment in schizophrenia and how improved treatment procedures can be developed and applied.     

Associations of Quality of Life,Physical Activity and Mood States in Women with Breast Cancer Treated with Curative Intent

This study aims to investigate the associations between quality of life, physical activity and mood states in women with breast cancer. A total of 354 women (mean age, 51.74?±?8.63 years; body mass index (BMI), 28?±?5.67 kg/m²) completed the Baecke Physical Activity Questionnaire, Profile of Mood States (POMS), European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) and European Organisation for Research and Treatment of Cancer Breast Cancer-Specific Quality of Life Questionnaire (EORTC QLQ-BR23). Pearson’s correlation and multiple linear regressions were used to verify the relations between outcomes and independent variables. Correlations between scores on POMS, Baecke Physical Activity Questionnaire and global health status/quality of life subscale of EORTC QLQ-C30 found associations (p?<?0.01) between physical activity (r?=?0.191), vigour (r?=?0.333) and fatigue (r?=??0.433). Multiple linear regression analysis of the global health status/quality of life subscale of the EORTC QLQ-C30 showed significant differences for vigour (p?<?0.001), social function (p?=?0.003), side effects of systemic therapy (p?=?0.019), arm and breast symptoms (p?<?0.001) and Baecke physical activity score (p?=?0.006). Physical activity is an independent factor related to the quality of life in women with breast cancer. Understanding these variables may influence clinical decisions during treatment and allow positive interventions regarding symptoms, functions and lifestyle.     

Evidence for kind representations in the absence of language: experiments with rhesus monkeys (Macaca mulatta)

How do we come to recognize and represent different kinds of objects in the world? Some developmental psychologists have hypothesized that learning language plays a crucial role in this capacity. If this hypothesis were correct, then non-linguistic animals should lack the capacity to represent objects as kinds. Previous research with rhesus monkeys (Macaca mulatta) has shown that this species can successfully individuate different kinds of objects - monkeys who saw one kind of object hidden inside a box searched longer after finding a different kind of object. However, in these studies and the infant studies on which they were based, the objects to be individuated differed both in kind and in properties. Thus, subjects in these experiments may not be representing the kinds of objects per se, but instead only their immediate perceptual properties. Here, we show that rhesus monkeys successfully individuate different kinds of objects even when their perceptual properties are held constant. Although these data provide the best evidence to date that language is not necessary to represent kinds, we discuss our findings in terms of possible associative hypotheses as well.     

The Effects of a Mental Health Video on the Social Skills Knowledge and Attitudes of Mexican Immigrants1

The purpose of this study was to evaluate the effects of a Spanish mental health video, “Cuida Su Salud Mental”, on the relationship attitudes and social skills knowledge of a Mexican immigrant sample. Subjects consisted of 72 Spanish speaking English as a second language (ESL) students recruited from the Paramount Adult School, in the county of Los Angeles. The Solomon (1949) Four Group Design was used. Half of the subjects were pretested on knowledge and attitudes about effective communication skills and relationships, respectively. All subjects view either the mental health video or a control video, and then were posttested on knowledge and attitudes. Results indicated that the mental healthy video (MHV) group exhibited more knowledge, F(1, 62) = 10.61, p= 0.002, and less risky attitudes, F(1, 62) = 4.29, p= 0.043, than the control video group. The MHV group also showed an increase in knowledge from the pretest to the posttest, F(1, 35) = 7.36, p= 0.01. Finally, both video groups reported a decrease in risky attitudes from pretest to posttest, F(1, 34) = 18.21, p= 0.001. These results support the use of “Cuida Su Salud Mental” as a productive and cost-effective mental health intervention that can be used to reach a large segment of the Spanish speaking community.     

Hey Buddy,Can You Spare Seventeen Cents? Mindful Persuasion and the Pique Technique1

According to the pique technique, a target is more likely to comply if mindless refusal is disrupted by a strange or unusual request. We demonstrated the use of this technique in two experiments. In Experiment 1, passersby on a local municipal wharf were approached by a confederate panhandler who made either one of two strange requests: “Can you spare 17¢ (or 37¢)?” or made either one of two typical requests “Can you spare a quarter (or any change)?” Subjects in the strange conditions were almost 60% more likely to give money than those receiving the typical plea. In addition, a strange request piqued interest as evidenced by increased verbal inquiries about the request. Experiment 2 replicated the first experiment in a laboratory setting and provides additional evidence (via a cognitive response analysis) that strange requests piqued subjects' interest in the appeal as well as increased liking for the panhandler.     

The association of macro- and microstructure of the corpus callosum and language lateralisation

The present study aimed to examine how differences in functional lateralisation of language are related to interindividual variations in interhemispheric connectivity. Utilising an fMRI silent word-generation paradigm, 89 left- and right-handed subjects were subdivided into four lateralisation subgroups. Applying morphological and diffusion-tensor MRI, midsagittal cross-sectional area as well as quantitative measures of molecular diffusion (anisotropy, mean diffusion) of the corpus callosum were determined to assess interhemispheric connectivity. Statistical analyses revealed group differences in molecular diffusion but not in callosal size, which may be interpreted to reflect a stronger and/or faster interhemispheric connection in strongly left-lateralised subjects as compared to moderately left-lateralised, bilateral, or moderately right-lateralised subjects.     

Stereotypes: static abstractions or dynamic knowledge structures?

Stereotypes have been assumed to be long-lasting knowledge structures that persist even in the face of contrary evidence. However, there is almost no within-participant research relevant to this assumption. The authors describe 4 studies (N=267), the first 3 of which assessed within-participant stereotype stability over a few weeks with measures of stereotypic trait verification, typicality ratings of exemplar sets, and exemplar retrieval. In the 4th study, the authors manipulated context stability. Overall, results showed only low-to-moderate stereotype stability. The stability obtained was a function of the perceived centrality of traits or exemplars and of context constancy. The authors discuss the implications of these results for abstractionist, exemplar, mixed, and connectionist models and identify possible mechanisms that underlie within-participant stereotype instability.     

Cross-cultural differences for three visual memory tasks in Brazilian children

Norms for three visual memory tasks, including Corsi's block tapping test and the BEM 144 complex figures and visual recognition, were developed for neuropsychological assessment in Brazilian children. The tasks were measured in 127 children ages 7 to 10 years from rural and urban areas of the States of S?o Paulo and Minas Gerais. Analysis indicated age-related but not sex-related differences. A cross-cultural effect was observed in relation to copying and recall of Complex pictures. Different performances between rural and urban children were noted.