Effect of catatoxic steroids upon lidocaine intoxication

Various steroids have been shown to influence the activity of psychotropic hormones and drugs. Among these, we distinguish “syntoxic” steroids which act by inhibiting excessive reactions to various agents and “catatoxic” steroids which actually destroy certain toxicants and hormones often through the induction of hepatic microsomal enzymes. Thus, the liver can play a decisive role in psychosomatic interrelations by regulating the blood clearance of agents affecting the nervous system. To illustrate these principles, new observations are presented which show that certain catatoxic steroids offer considerable protection against lidocaine, an anesthetic, analgesic drug. These findings may serve as an example showing how modern research techniques may help us to analyze the possible relationships between the liver and the mind, which were intuitively suspected since Hippocrates created the term “melancholia.”     

Data on the role of the frontal cortex in vegetative behavior

A homeostatic conditional reflex (CR) was elaborated to the effect of repeated inhalations in rats of a gas mixture containing 8 per cent oxygen. The effect of the conditional response was opposite to that of the unconditional one. After ablation of the frontal cortex, the conditional reaction disappeared. The repeated administration of 40 mg/kg of histamine resulted in a tolerance to the temperature lowering effect of histamine similar to the habituation. An injection of distilled water brought about dishabituation. Tolerance was not influenced by the ablation of the frontal cortex, but the dishabituating effect of distilled water was absent.     

The moderating role of self-monitoring on the interpersonal aspects of attitude ambivalence

Extant research has found a relation between holding conflicting attitudes with a familiar person (interpersonal discrepancy) and subjective attitude ambivalence. In 2 studies, we investigated the role of interpersonal discrepancy in the experience of attitude ambivalence as a function of self-monitoring and level of liking of the other person. Building on balance theory, we proposed and found that high (vs. low) self-monitors feel most comfortable when they are in agreement with liked (vs. disliked) others. In Study 1, 80 university students revealed that when the significant other is a parent, high self-monitors feel more subjective ambivalence when there is more interpersonal discrepancy. In Study 2, 37 university students reported their feelings of subjective ambivalence when considering the interpersonal discrepancy between liked (vs. disliked) familiar people. Again, it was high self-monitors who were most susceptible to increased feelings of subjective ambivalence, particularly for discrepancies between their own attitude and the attitude of liked others. Taken together, our 2 studies broaden our understanding of the interpersonal foundations of subjective ambivalence by suggesting that they may depend on personality differences and the nature of the social relationship.     

The legacy of Hans Selye and the origins of stress research: A retrospective 75 years after his landmark brief "Letter" to the Editor(#) of Nature

Hans Selye's single author short letter to Nature (1936, 138(3479):32) inspired a huge and still growing wave of medical research. His experiments with rats led to recognition of the "general adaptation syndrome", later renamed by Selye "stress response": the triad of enlarged adrenal glands, lymph node and thymic atrophy, and gastric erosions/ulcers. Because of the major role of glucocorticoids (named by Selye), he performed extensive structure-activity studies in the 1930s-1940s, resulting in the first rational classification of steroid hormones, e.g. corticoids, testoids/androgens, and folliculoids/estrogens. During those years, he recognized the respective anti- and pro-inflammatory actions of gluco- and mineralocorticoids in animal models, several years before demonstration of anti-rheumatic actions of cortisone and adrenocorticotrophic hormones in patients. Nevertheless, Selye did not receive a Nobel Prize, which was awarded in 1950 to the clinician Hench and the two chemists who isolated and synthesized some of the glucocorticoids. Nonetheless, Selye was internationally recognized as a world authority in endocrinology, steroid chemistry, experimental surgery, and pathology. He wrote over 1500 original and review articles, singly authored 32 books, and trained 40 PhD students, one of whom (Roger Guillemin) won a Nobel Prize for isolating the hypothalamic releasing factors/hormones. Here, we consider the main implications of his first article launching the biological stress concept and the key ideas and problems that occupied him. Selye considered "Stress in heath and disease is medically, sociologically, and philosophically the most meaningful subject for humanity that I can think of".     

Response of the norepinephrine system to antidepressant drugs

Environmental stimuli and drugs affect the norepinephrine (NE) system and may be linked to the manifestation and treatment of anxiety and affective disorders. The activity of locus ceruleus NE neurons in the brainstem can alter the function of forebrain structures associated with several psychiatric disorders. In particular, NE neurons send and receive projections from sensory afferents, limbic areas, and cortical areas implicated in higher-order brain malfunctions and the symptomatology of anxiety and affective disorders. In turn, anxiolytic and antidepressant drugs are able to offset perturbations of NE activity and forebrain structures with a time course congruent with their therapeutic action. All antidepressants, even the agents selective for other biogenic amines or peptides, act on the NE system. In the present review, the effects of antidepressants on NE neurons are summarized and applied to the treatment of neuropsychiatric disorders, with emphasis placed on mechanisms of action.     

A Model for the Role of Defined Spirituality in South African Specialist Psychiatric Practice and Training

The current bio-psycho-social approach in South African psychiatry refers to Engel’s extended model of health care. It forms the basis of the existing collaboration between medicine, nursing, psychology, occupational therapy and social work. Psychiatry also has to bridge the multi-cultural, multi-religious and spiritual diverse reality of everyday practice. It has become important to establish how, within accepted boundaries, spirituality should be incorporated into the model for practice. Referring to methods described for nursing theory development, a defined core concept was used to construct a model. It may contribute to the discourse on spirituality in local psychiatry, health and mental health.     

Effects of a carbohydrate supplement upon resting brain activity

Glucose is a major energy source for the brain, and along with several monosaccharide derivatives as components of brain gangliosides, they play important roles in neurologic function. However, there is little information available on the role of glucose and other monosaccharides on resting brain activity. This study was designed to evaluate the effects of a single dose of a carbohydrate supplement containing glucose and several of its derivatives on resting brain activity in 20 healthy male college students. The supplement provided an insignificant amount of carbohydrate (3.9 g), protein (0.28 g), fat (0 g), and calories (14 kcal). The amount of glucose in the supplement was 0.5 g (1% the amount of glucose used in adult studies of cognitive functioning and memory). We hypothesized that the glyconutrient supplement would enhance brain activity associated with alertness and attention. The study design was double blind, with subjects randomly assigned to one of two orders, either carbohydrate supplement week one followed by placebo a week later, or the opposite. Electrical brain activity was monitored by 15 electrodes positioned at nine standard international 10–20 system locations, including three bilateral pairs at frontal, parietal, and occipital sites. Thirty minutes following ingestion of a placebo or carbohydrate supplement drink, EEG activity was recorded for 10-mins while subjects focused on a stationary visual target. Spectral power of resting brain activity was computed and analyzed contrasting the placebo and supplement groups. Relative to placebo, the carbohydrate supplement significantly enhanced power in three brain wave frequencies (theta, alpha, and beta) that are known to be associated with attention and arousal. Since changes were observed in the supplement but not placebo group, our study suggests that additional sugars in the glyconutritional supplement facilitate enhancement of brain electrical activity. Whether the apparent enhancement of arousal in baseline recordings is associated with improved task performance remains to be determined.     

Fear of the new? Geckos hesitate to attack novel prey,feed near objects and enter a novel space

Animal Cognition - Neophobia, the fear of novelty, is an ecologically important response which enables animals to avoid potentially harmful situations. Neophobia is a cognitive process by which...     

On the Independent Roles of Cognitive & Political Sophistication: Variation Across Attitudinal Objects

People are motivated to maintain consistency between importantly held identities, preferences, and judgments. In political contexts, motivated reasoning can help explain a wide range of political phenomena, including extremism, polarization, and misperceptions. However, recent findings in psychology have challenged this account. These perspectives emphasize the role of cognitive sophistication (e.g., analytical reasoning, numerical literacy) in political attitudes, but differ in terms of whether it is expected to attenuate or exacerbate politically motivated reasoning and belief in conspiracy theories. Yet prior investigations have not examined the relative and independent effects of both political and cognitive sophistication. Using data from two samples, including one sampled to approximate representativeness in the U.S., we demonstrate that both types of sophistication have independent and (at times) countervailing effects on belief in COVID-19 conspiracy theories and other political attitudes. Our results are critical for theories of cognitive sophistication, political cognition, and attitudes, and the psychology of conspiracy theories.     

Coherence in cartesian closed categories and the generality of proofs

We introduce the notion of an alphabetic trace of a cut-free intuitionistic prepositional proof and show that it serves to characterize the equality of arrows in cartesian closed categories. We also show that alphabetic traces improve on the notion of the generality of proofs proposed in the literature. The main theorem of the paper yields a new and considerably simpler solution of the coherence problem for cartesian closed categories than those in [11, 14].This research was supported in part by N.S.E.R.C. Grant A-8224 and F.C.A.R. Grant EQ-3491. The author is attached to the Centre interuniversitaire en études catégoriques, McGill University, Montreal.