Impaired appetitively as well as aversively motivated behaviors and learning in PDE10A-deficient mice suggest a role for striatal signaling in evaluative salience attribution

Phosphodiesterase 10A (PDE10A) hydrolyzes both cAMP and cGMP, and is a key element in the regulation of medium spiny neuron (MSN) activity in the striatum. In the present report, we investigated the effects of targeted disruption of PDE10A on spatial learning and memory as well as aversive and appetitive conditioning in C57BL/6 J mice. Because of its putative role in motivational processes and reward learning, we also determined the expression of the immediate early gene zif268 in striatum and anterior cingulate cortex. Animals showed decreased response rates in scheduled appetitive operant conditioning, as well as impaired aversive conditioning in a passive avoidance task. Morris water maze performance revealed not-motor related spatial learning and memory deficits. Anxiety and social explorative behavior was not affected in PDE10A-deficient mice. Expression of zif268 was increased in striatum and anterior cingulate cortex, which suggests alterations in the neural connections between striatum and anterior cingulate cortex in PDE10A-deficient mice. The changes in behavior and plasticity in these PDE10A-deficient mice were in accordance with the proposed role of striatal MSNs and corticostriatal connections in evaluative salience attribution.     

How do High School Youths’ Educational Experiences Relate to Well-Being? Towards a Trans-Disciplinary Conceptualization

Educational research and practice could benefit from and contribute to multi-disciplinary study of well-being. In particular, research on the well-being of youth within and beyond school may benefit students, educators, administrators, and the community. This review provides a conceptual framework that (a) integrates research on well-being from economics, sociology, psychology and the health sciences, (b) organises this literature within seven domains of inquiry: Having, Being, Relating, Thinking, Feeling, Functioning, and Striving, and (c) highlights research pertinent to senior high school level educational experiences. This framework provides an important foundation from which further research on well-being can be developed.     

Voice pitch influences perceptions of sexual infidelity

Sexual infidelity can be costly to members of both the extra-pair and the paired couple. Thus, detecting infidelity risk is potentially adaptive if it aids in avoiding cuckoldry or loss of parental and relationship investment. Among men, testosterone is inversely related to voice pitch, relationship and offspring investment, and is positively related to the pursuit of short-term relationships, including extra-pair sex. Among women, estrogen is positively related to voice pitch, attractiveness, and the likelihood of extra-pair involvement. Although prior work has demonstrated a positive relationship between men?s testosterone levels and infidelity, this study is the first to investigate attributions of infidelity as a function of sexual dimorphism in male and female voices. We found that men attributed high infidelity risk to feminized women?s voices, but not significantly more often than did women. Women attributed high infidelity risk to masculinized men?s voices at significantly higher rates than did men. These data suggest that voice pitch is used as an indicator of sexual strategy in addition to underlying mate value. The aforementioned attributions may be adaptive if they prevent cuckoldry and/or loss of parental and relationship investment via avoidance of partners who may be more likely to be unfaithful.     

Some considerations about the biological appearance of pacing stimuli in visuomotor finger-tapping tasks

Sensorimotor synchronization is a crucial function for human daily activities, which relies on the ability of predicting external events. Synchronization performance, as assessed in finger-tapping (FT) tasks, is characterized by an anticipation tendency, as the tap generally precedes the pacing event. This synchronization error (SE) depends on many factors, in particular on the features of the pacing stimulus. Interest is growing in the facilitation effect that action observation has on motor execution. So far, neuroimaging and neurophysiology studies of motor priming via action observation have mainly employed tasks requiring single action instances. The impact of action observation on motor synchronization to periodic stimuli has not yet been tested; to this aim, a synchronization FT task may be an eligible probing task. The purpose of this study was to characterize a biological pacer at the behavioral level and provide information for those interested in studying the brain processes of continuous observation/execution coupling in timed actions using FT tasks. We evaluated the influence of the biological appearance of a pacer (a tapping finger) on SE, when compared to an abstract, kinematically equivalent pacer (a tilting hinged bar) and a more standard stimulus (a pulsating dot). We showed that the continuous visual display of a biological pacer yields comparable results to the abstract pacer, and a more robust performance and larger anticipations than a traditional pulsating stimulus.     

Deliberating About the Public Interest

Although the idea of the public interest features prominently in many accounts of deliberative democracy, the relationship between deliberative democracy and the public interest is rarely spelt out with any degree of precision. In this article, I identify and defend one particular way of framing this relationship. I begin by arguing that people can deliberate about the public interest only if the public interest is, in principle, identifiable independently of their deliberations. Of course, some pluralists claim that the public interest is an implausible idea, which casts doubt on the idea that there might be something for people to deliberate about. Yet while, following Brian Barry, we can get around this problem by defining the public interest as an interest in which everyone shares qua member of the public, what still needs to be explained is why people should be prepared to privilege this particular capacity. I argue that the account of political equality with which deliberative democracy is bound up offers a compelling explanation of this sort, even if it also gives rise to some difficult questions of feasibility. I conclude by considering the charge that any political scheme that framed the relationship between deliberative democracy and the public interest in this way would be undesirable.     

Vegetative state: efforts to curb misdiagnosis

Media reports on the case of Rom Houben have constituted a new reminder of the risks of misdiagnosis with cases with apparent vegetative state, particularly when following the clinical consensus of the care team as diagnostic criterion. Systematic use of behavioral and non-behavioral assessment strategies (e.g., behavioral scales, event-related potentials, and neuro-imaging) may help reduce the aforementioned risks. A new learning assessment strategy could also be considered part of the assessment to extend the evaluation process. Signs of learning might be viewed as forms of concrete knowledge representing a basic level of non-reflective consciousness.     

Authenticity in the Zhuangzi ? Contemporary Misreadings of Zhen 真and an Alternative to Existentialism

This essay reviews the Zhuangzian notion of zhen 真, often through the text’s advancement of the zhenren 真人 (“genuine person,” “true person”) or zhenzhi 真知 (“genuine knowledge,” “true knowledge”). Contemporary scholarship, in both Chinese and English, often presents zhen as analogous to the existentialist theory of authenticity, which correspondingly reflects on interpretations of the “self,” and thereby the zhen person. Much of the Zhuangzi is a reaction to the Lunyu, including an ironic response to the Confucian cultivation project. If we establish our interpretation of the “self” against this background then we find that zhen in the Zhuangzi is actually used to argue against the Confucian identification of the person and self through social roles or conventions. However, advocating zhen does not suggest that there is some essential or core “self” to refer to; instead, it implies a natural state of responsiveness where the person acts efficaciously by being in line with what is obvious or affirmed in the situation. This essay thereby presents a reading of zhen that is historically and culturally consistent, and sets up the Zhuangzi as an alternative, and not an echo, to some of the major issues dealt with by the existentialist movement.     

Object-based selection in the Baylis and Driver (1993) paradigm is subject to space-based attentional modulation

Three experiments re-examined Baylis and Driver's (1993) strong evidence for object-based selection, that making relative apex location judgments is harder between two objects than within a single object, with object (figure-ground) segmentation determined solely by color-based perceptual set. Using variations of the Baylis and Driver paradigm, the experiments replicated a two-object cost. However, they also showed a large part of the two-object cost to be attributable to space-based factors, though there remained an irreducible cost consistent with 'true' object-based selection.