Negative emotional processing induced by spoken scenarios modulates corticospinal excitability

Emotion is assumed to facilitate the preparation of behavioral responses to environmental stimuli. In the present study, we examined whether emotional processing induced by spoken scenarios of positive and negative content, related to the self or to other people, modulates corticospinal excitability. Motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) in 20 volunteers indicated that processing of negative emotional content increased MEP amplitude, regardless of the perspective taken in the scenario. By contrast, positive emotional processing did not reliably alter MEP amplitude. These results provide the first TMS evidence that the auditory processing of emotionally negative information triggers action preparation.     

Age and sex differences in reaction time in adulthood: results from the United Kingdom Health and Lifestyle Survey

Reaction times (RTs) slow and become more variable with age. Research samples are typically small, biased, and of restricted age range. Consequently, little is known about the precise pattern of change, whereas evidence for sex differences is equivocal. The authors reanalyzed data for 7,130 adult participants in the United Kingdom Health and Lifestyle Survey, originally reported by F. A. Huppert (1987). The authors modeled the age differences in simple and 4-choice reaction time means and variabilities and tested for sex differences. Simple RT shows little slowing until around 50, whereas choice RT slows throughout the adult age range. The aging of choice RT variability is a function of its mean and the error rate. There are significant sex differences, most notably for choice RT variability.     

Researchers misunderstand confidence intervals and standard error bars

Little is known about researchers' understanding of confidence intervals (CIs) and standard error (SE) bars. Authors of journal articles in psychology, behavioral neuroscience, and medicine were invited to visit a Web site where they adjusted a figure until they judged 2 means, with error bars, to be just statistically significantly different (p < .05). Results from 473 respondents suggest that many leading researchers have severe misconceptions about how error bars relate to statistical significance, do not adequately distinguish CIs and SE bars, and do not appreciate the importance of whether the 2 means are independent or come from a repeated measures design. Better guidelines for researchers and less ambiguous graphical conventions are needed before the advantages of CIs for research communication can be realized.     

Learning during the newborn's first meal: special resistance to retroactive interference

At their first postnatal meal, 3-hour-old rats learned an association between an odor and a sweet or bitter taste. Retention after a long interval or after associative interference was compared to that of 1-day-old rats. Despite equivalent and negligible effect of the long retention interval, contrary to infantile amnesia, newborns differed strikingly from 1-day-olds in susceptibility to associative interference. When lemon odor predicted saccharin in the first episode but quinine in the second, 1-day-olds had strong retroactive interference, but the newborn's first memory was unaffected by the second. The results were identical when the first memory was a lemon-quinine association and the second a lemon-saccharin association. It is uncertain whether this special robustness of memories associated with the first postnatal meal is best understood in terms of cognitive primacy or neurochemical and physiological consequences of the birth process.     

Using overt rehearsals to explain word frequency effects in free recall

Three experiments examined the word frequency effect in free recall using the overt rehearsal methodology. Experiment 1 showed that lists of exclusively high-frequency (HF) words were better recalled, were rehearsed more, and were rehearsed to more recent serial positions than low-frequency (LF) words. A small HF advantage remained even when these 2 variables were equated. Experiment 2 showed that all these effects were much reduced with mixed lists containing both HF and LF words. Experiment 3 compared pure and mixed lists in a within-subject design and confirmed the findings of Experiments 1 and 2. It is argued that number of rehearsals, recency of rehearsals, and strength of interitem associations cause the word frequency effect in free recall.     

IQ stability: the relation between child and young adult intelligence test scores in low-birthweight samples

The stability of IQ from childhood to adulthood in low-birthweight subjects was measured in two independent samples with follow-up intervals of approximately 14 and 9.5 years. In both samples, intelligence was assessed with the WISC at a mean age of 9.5. Twenty-six subjects were retested with the WAIS at a mean age of 23.5, and 78 subjects with the BPP (the Danish Military Draft Board Intelligence Test) at the age of 19.1. Both samples obtained childhood and adult test scores below the expected means. For the Wechsler Verbal, Performance and Full-Scale IQs, the stability quotients were 0.86, 0.86, and 0.89 in the WAIS sample, and the retest correlations for the three IQs with the BPP score were 0.66, 0.65, and 0.74. Thus, the majority of children showed stable patterns of intellectual development from middle childhood to young adulthood.     

Pre-training prevents context fear conditioning deficits produced by hippocampal NMDA receptor blockade

These experiments explore parallels between the neurobiological substrates of spatial and context learning. Male Long-Evans rats were employed in a context fear conditioning protocol that involved sequential acquisition and testing in two distinct contexts. Rats received three unsignaled footshocks in one context and were tested for context fear, measured as freezing, the next day. Four days later, the procedure was repeated in a different, distinct context. Rats received a hippocampal infusion of either the NMDA receptor antagonist 5-amino-phosphonovaleric acid (APV, 10 microg) or vehicle prior to training in each context. NMDA receptor blockade was effective in impairing context learning only in the first context. Context fear acquisition was not impaired by APV in the second context, indicating that pre-training (in the first context) mitigated the effects of APV. These data agree with those seen previously in the water maze, where pre-training prevented learning deficits produced by NMDA receptor blockade. The data thus suggest that the neurobiological substrates of context learning and place learning overlap.     

Discrete vs. continuous processing: The fate of an incompletely processed perceptual dimension

A relevant issue in the debate on continuous vs. discrete processing of information is whether incompletely processed information does or does not affect a subsequent reaction. Two stimuli (SL, SR) were presented on eye level, subtending a visual angle of 45 degrees. SL was always inspected first, followed by a saccade to SR and finally by a same/different response. The fixation time of SL (TL), the saccadic time (TM) and the time from fixating SR to the response (TR) were separately measured. SL and SR consisted of two-dimensional stimuli (size and letter shape) constructed in such a way that encoding size took longer for one group and encoding shape took longer for another group of 10 subjects. All subjects were tested in three conditions: Shape was relevant in one, size in the second, and both dimensions were relevant in the third condition.

TL was less when encoding the relevant dimension was fast. When both dimensions were relevant, TL was about as long as when only the slow dimension was relevant, suggesting parallel and interference-free processing during TL. When only the slow dimension was relevant, TR (same) was much longer when the fast dimension differed. When the fast dimension was relevant, TR (same) was slightly longer when the slow dimension differed, which can be handled by either model. The experiment was repeated with three well-practiced and less variable subjects who carried out sufficient trials to measure TR as a function of TL. The results of this study were in line with the discrete model: A different slow and irrelevant dimension did not affect the same response regardless of the duration of TL. Interestingly, subjects were capable of retrieving the slow dimension, suggesting a code which can be used for retrieval but which does not affect the same/different response.     

Perception of signals presented in the periphery of the visual field

Two experiments were performed which tested the type of information that can be extracted from the periphery of the visual field, i.e. content information or position information. In both studies two digits were compared, one presented at the left and one at the right of the subject's meridian, seperated by a binocular visual angle, comprising either an eye-field (45°) or a head-field display (100°). In the first experiment the right signal was presented in separate blocks of either degraded or undegraded digits. In the case of undegraded digits, processing efficiency was better in the eye-field than in the head-field. With degraded digits this eye-field advantage was significantly smaller, but did not altogether disappear, suggesting that information about both the content and the position of digits in the periphery is acquired in the eye-field as opposed to the head-field. In the second experiment degraded and undegraded digits occured randomly within the same block of trials. This was done to investigate whether peripheral information is acquired automatically or through controlled processing. The results indicate a small eye-field advantage, about equal for both degraded and undegraded digits. This supports the controlled processing hypothesis, at least with regard to the acquisition of content information from the periphery.