Cognition and lobar morphology in full mutation boys with fragile X syndrome

The aims of the present study are twofold: (1) to examine cortical morphology (CM) associated with alterations in cognition in fragile X syndrome (FXS); (2) to characterize the CM profile of FXS versus FXS with an autism diagnosis (FXS + Aut) as a preliminary attempt to further elucidate the behavioral distinctions between the two sub-groups. We used anatomical magnetic resonance imaging surface-based morphometry in 21 male children (FXS N = 11 and age [2.27-13.3] matched controls [C] N = 10). We found (1) increased whole hemispheric and lobar cortical volume, cortical thickness and cortical complexity bilaterally, yet insignificant changes in hemispheric surface area and gyrification index in FXS compared to C; (2) linear regression analyses revealed significant negative correlations between CM and cognition; (3) significant CM differences between FXS and FXS + Aut associated with their distinctive behavioral phenotypes. These findings are critical in understanding the neuropathophysiology of one of the most common intellectual deficiency syndromes associated with altered cognition as they provide human in vivo information about genetic control of CM and cognition.     

Pragmatic and Transcendental Arguments for Theism: a Critical Examination

Commenting upon some recent literature on the topic, this paper examinestwo strategies by means of which one might try to defend theism: (1) a pragmatic (Jamesian) strategy, which focuses on the idea that religiousbelief has beneficial consequences in the believer's life, and (2) a transcendental (Kantian) strategy, according to which theism is requiredas a condition of our self-understanding as ethically oriented creatures.Both strategies are found unsatisfactory, unless synthesized and thussupported by each other. While no argument, either pragmatic ortranscendental, can demonstrate the existence of God, a pragmatictranscendental argument might have a legitimate role to play in thephilosophy of religion. The problem of relativism arises, however. It isconcluded that it remains unclear whether a religious believer could justifyher or his beliefs to anyone who does not already share those beliefs.     

Abstract morphemes and lexical representation: the CV-Skeleton in Arabic

Overlaps in form and meaning between morphologically related words have led to ambiguities in interpreting priming effects in studies of lexical organization. In Semitic languages like Arabic, however, linguistic analysis proposes that one of the three component morphemes of a surface word is the CV-Skeleton, an abstract prosodic unit coding the phonological shape of the surface word and its primary syntactic function, which has no surface phonetic content (McCarthy, J. J. (1981). A prosodic theory of non-concatenative morphology, Linguistic Inquiry, 12 373-418). The other two morphemes are proposed to be the vocalic melody, which conveys additional syntactic information, and the root, which defines meaning. In three experiments using masked, cross-modal, and auditory-auditory priming we examined the role of the vocalic melody and the CV-Skeleton as potential morphemic units in the processing and representation of Arabic words. Prime/target pairs sharing the vocalic melody but not the CV-Skeleton consistently failed to prime. In contrast, word pairs sharing only the CV-Skeleton primed reliably throughout, with the amount of priming being as large as that observed between word pattern pairs sharing both vocalic melody and CV-Skeleton. Priming between morphologically related words can be observed when there is no overlap either in meaning or in surface phonetic form.     

The Transcendental Method and (Post-)Empiricist Philosophy of Science

This paper reconsiders the relation between Kantian transcendental reflection (including transcendental idealism) and 20th century philosophy of science. As has been pointed out by Michael Friedman and others, the notion of a “relativized a priori” played a central role in Rudolf Carnap’s, Hans Reichenbach’s and other logical empiricists’ thought. Thus, even though the logical empiricists dispensed with Kantian synthetic a priori judgments, they did maintain a crucial Kantian doctrine, viz., a distinction between the (transcendental) level of establishing norms for empirical inquiry and the (empirical) level of norm-governed inquiry itself. Even though Thomas Kuhn’s theory of scientific revolutions is often taken to be diametrically opposed to the received view of science inherited from logical empiricism, a version of this basically Kantian distinction is preserved in Kuhn’s thought. In this respect, as Friedman has argued, Kuhn is closer to Carnap’s theory of linguistic frameworks than, say, W.V. Quine’s holistic naturalism. Kuhn, indeed, might be described as a “new Kant” in post-empiricist philosophy of science. This article examines, first, the relativization of the Kantian a priori in Reichenbach’s work, arguing that while Reichenbach (after having given up his original Kantianism) criticized “transcendentalism”, he nevertheless retained, in a reinterpreted form, a Kantian-like transcendental method, claiming that the task of philosophy (of science) is to discover and analyze the presuppositions underlying the applicability of conceptual systems. Then, some reflections on Kuhn’s views on realism are offered, and it is suggested that Kuhn (as well as some other influential contributors to the realism debate, such as Hilary Putnam) can be reinterpreted as a (relativized, naturalized) Kantian transcendental idealist. Given the central importance of Kuhnian themes in contemporary philosophy of science, it is no exaggeration to claim that Kantian transcendental inquiry into the constitutive principles of empirical knowledge, and even transcendental idealism (as the framework for such inquiry), still have a crucial role to play in this field and deserve further scrutiny.     

Children’s mental health: Time to stop using psychiatric diagnosis

Hegemonic mental health service approaches stress the need for ‘accurate’ diagnosis in order to understand what the correct ‘treatment’ should be. I review the evidence on how far diagnosis in psychiatry has helped advance scientific knowledge and clinical practice and conclude that it hasn’t. I then examine how National Institute for Health and Care Excellence (NICE) guidelines in relation to children’s behaviour problems reflects the lack of progress that results from adopting a diagnostic approach. Taking mental health practice beyond reliance on narrow non-evidence-based diagnostic algorithms can be developed by adopting existing projects such as the Partners for Change Outcome Management Systems project.     

Fundamental movement skills and motivational factors influencing engagement in physical activity

To assess whether subgroups based on children's fundamental movement skills, perceived competence, and self-determined motivation toward physical education vary with current self-reported physical activity, a sample of 316 Finnish Grade 7 students completed fundamental movement skills measures and self-report questionnaires assessing perceived competence, self-determined motivation toward physical education, and current physical activity. Cluster analysis indicated a three-cluster structure: "Low motivation/low skills profile," "High skills/low motivation profile," and "High skills/high motivation profile." Analysis of variance indicated that students in the third cluster engaged in significantly more physical activity than students of clusters one and two. These results provide support for previous claims regarding the importance of the relationship of fundamental movement skills with continuing engagement in physical activity. High fundamental movement skills, however, may represent only one element in maintaining adolescents' engagement in physical activity.     

Wittgenstein on Happiness: Harmony,Disharmony and Antitheodicy

This paper investigates Wittgenstein's remarks on happiness and harmony in the context of Wittgensteinian antitheodicy. Philosophers of religion inspired by Wittgenstein's philosophy often criticize theodicies seeking to justify apparently meaningless evil and suffering within God's overall harmonious plan. The paper analyses Wittgenstein's early views on happiness as harmony with the world, examining whether they are incompatible with an antitheodicist approach abandoning the very project of theodicy by acknowledging a certain kind of disharmony. However, antitheodicy may also, at the transcendental meta‐level, be considered a “harmonious” way of “seeing the world aright,” which raises a reflexive problem for any Wittgenstein‐inspired antitheodicy.     

How the Future Orientation of Traditional Israeli Palestinian Girls Links Beliefs About Women's Roles and Academic Achievement

A model in which future orientation links perceived fathers' and girls' beliefs about traditional women's roles and academic achievement was tested on data collected from traditional Israeli Palestinian girls  ( N = 295)  attending a Moslem all-girl senior high school. LISREL analyses estimated two empirical models pertaining to educational and family future orientation. The estimated models showed that fathers' perceived beliefs were directly linked to academic achievement and future orientation partially mediated the relationships between girls' beliefs about women's roles and academic achievement. Girls' beliefs were negatively linked to the educational future orientation and positively linked to the family future orientation, and the educational model explained a larger percent of the variance of academic achievement than did the family model.